Study on the Covalent Immobilization of Captopril onto Polymer Microspheres

Miao ZHANG; Shi-jiang FANG; Zhi-min JIN

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Study on the Covalent Immobilization of Captopril onto Polymer Microspheres

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- Study on the Covalent Immobilization of Captopril onto Polymer Microspheres
- Polymer Bulletin Vol. 25, Issue 8, Pages: 85-91(2012)
- 作者机构：
  
  1.浙江大学化学工程国家重点实验室、聚合与聚合物工程研究所，杭州　310027
  2.浙江工业大学药学院，杭州　310014
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012-08，
  
  Received：28 December 2011，
  
  Revised：26 March 2012，
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Miao ZHANG, Shi-jiang FANG, Zhi-min JIN. Study on the Covalent Immobilization of Captopril onto Polymer Microspheres. [J]. Polymer Bulletin 25(8):85-91(2012)
DOI：

Miao ZHANG, Shi-jiang FANG, Zhi-min JIN. Study on the Covalent Immobilization of Captopril onto Polymer Microspheres. [J]. Polymer Bulletin 25(8):85-91(2012) DOI：

摘要

采用无皂乳液聚合法制得聚苯乙烯-甲基丙烯酸缩水甘油酯(PSG)乳液微球

然后在微球表面嫁接空间臂分子1

6-己二胺

得到表面含氨基的PSGN微球

接着借助EDC/NHS催化作用将药物分子卡托普利化学偶联到PSGN微球表面

制成固定卡托普利的亲和PSG微球。实验着重考察了PSGN微球偶联固定卡托普利反应过程中催化剂比例和用量、pH值、反应温度和时间等的影响规律。结果表明

在25℃

pH为4.0

m(NHS)∶m(EDC)=1∶2

EDC的浓度为4mg/mL的条件下

卡托普利偶联到微球表面的效果较好。

Abstract

The poly (styrene-co-glycidyl methacrylate) (PSG) latex microspheres were prepared by soap-free emulsion polymerization. The resulted PSG microspheres were further modified with 1

6-hexanediamine as a space arm to get the amino-modified PSGN microsphere. Captopril was coupled onto the surface of PSGN microspheres by the activation with N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) and N-Hydroxysuccinimide (NHS)

so that the affinity polymer microspheres immobilized captopril was finally obtained. The effects of the ratio and concentration of catalysts

temperature and time on the coupling reaction between the PSGN microspheres and captopril were examined. It was shown that the effect of immobilization was much better under the condition of 25℃

pH=4.0

m(NHS)∶m(EDC)=1∶2

m(EDC)=4mg/mL.

关键词

无皂乳液聚合亲和微球卡托普利苯乙烯甲基丙烯酸缩水甘油酯

Keywords

Soap-free emulsion polymerizationAffinity polymer microsphereCaptoprilStyreneGlycidyl methacrylate

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