Study on Synthesis and Properties of Amphiphilic Polyethylene Glycol Eleostearic Acid Ester

Bai-xin ZHANG; Chun-bo LAN; Xiao-dong LIU; Miao XIAN; Bi-jing SHA; Jing-chan ZHAO

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Study on Synthesis and Properties of Amphiphilic Polyethylene Glycol Eleostearic Acid Ester

更新时间：2022-09-18

- Study on Synthesis and Properties of Amphiphilic Polyethylene Glycol Eleostearic Acid Ester
- Polymer Bulletin Vol. 25, Issue 12, Pages: 68-73(2012)
- 作者机构：
  
  西北大学合成与天然功能分子化学教育部重点实验室/化学与材料科学学院，西安　710069
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012-12，
  
  Received：28 May 2012，
  
  Revised：16 August 2012，
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Bai-xin ZHANG, Chun-bo LAN, Xiao-dong LIU, Miao XIAN, Bi-jing SHA, Jing-chan ZHAO. Study on Synthesis and Properties of Amphiphilic Polyethylene Glycol Eleostearic Acid Ester. [J]. Polymer Bulletin 25(12):68-73(2012)
DOI：

Bai-xin ZHANG, Chun-bo LAN, Xiao-dong LIU, Miao XIAN, Bi-jing SHA, Jing-chan ZHAO. Study on Synthesis and Properties of Amphiphilic Polyethylene Glycol Eleostearic Acid Ester. [J]. Polymer Bulletin 25(12):68-73(2012) DOI：

摘要

以桐油酸(ESA)和聚乙二醇(PEG)为原料

合成了一种新型的两亲性聚合物聚乙二醇-桐油酸酯(PEG-ESA)。通过红外光谱、质谱和核磁共振光谱法对产物进行表征。利用表面张力法和荧光探针法探究聚合物溶液相关性质

测定不同条件下两亲性聚合物胶束的zeta(ζ)电位和粒径。实验结果表明:利用表面张力法测得PEG-ESA临界胶束浓度(CMC)为1.1×10

-5

g/L;芘可以增溶于聚合物胶束中;在一定条件下聚合物的胶束可以稳定存在且粒径可达纳米级

为其用于药物缓释提供实验依据。

Abstract

A new amphiphilic polymer polyethylene glycol-eleostearic acid ester (PEG-ESA) was synthesized by esterification using polyethylene glycol and eleostearic acid as reactants. The product was characterized by IR

MALDI-TOF-MS and 1HNMR. The properties of PEG-ESA were explored over both fluorescent probe and surface tension. The zeta potential and partical size of micellar solutions of PEG-ESA were studied in different conditions. The critical micelle concentration (CMC) of PEG-ESA was 1.1×10

-5

g/L

the water solubility of pyrene was enhanced by micellar solution of the new aliphatic ester. The micelle of PEG-ESA was stable and reached nanoscale under certain conditions.

关键词

桐油酸聚乙二醇两亲性聚合物

Keywords

Eleostearic acidPolyethylene glycolAmphiphilic polymer

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