Liver disease is one of the most serious deseases which pose significant health challenge worldwide. Advances in treatment

detection

surgical techniques have resulted in considerable improvements in therapy of liver disease. It has aroused extensive attention of researchers that targeted drug delivery system can delivery the drug selectively to the target tissue

thereby improving the bioavailability of the drug and reduce its side effects. In recent years

increasing researchers have attempted to apply targeted drug delivery system (TDDS) to the imaging detection of the liver disease and drug/gene therapy

and achieved significant results. This review addresses the latest development of the liver TDDS in recent years

especially the ligand/receptor-mediated liver TDDS in drug/gene delivery or imaging detection;summarize the liver targeting ability of different TDDS

and then discusses the challenges and future perspectives for the development of liver TDDS.