Review of the Polymeric Anticancer Drug Delivery System

Yuan-kun DAI; Ji-dong HE; Xin ZHANG; Xue JIANG

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Review of the Polymeric Anticancer Drug Delivery System

更新时间：2022-09-18

- Review of the Polymeric Anticancer Drug Delivery System
- Polymer Bulletin Vol. 26, Issue 5, Pages: 34-39(2013)
- 作者机构：
  
  青岛科技大学，橡塑材料与工程教育部重点实验室/山东省橡塑材料与工程重点实验室，青岛　266042
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013-05，
  
  Received：16 November 2012，
  
  Revised：19 December 2012，
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Yuan-kun DAI, Ji-dong HE, Xin ZHANG, Xue JIANG. Review of the Polymeric Anticancer Drug Delivery System. [J]. Polymer Bulletin 26(5):34-39(2013)
DOI：

Yuan-kun DAI, Ji-dong HE, Xin ZHANG, Xue JIANG. Review of the Polymeric Anticancer Drug Delivery System. [J]. Polymer Bulletin 26(5):34-39(2013) DOI：

摘要

癌症是导致世界死亡率居高不下的主导原因之一

利用抗癌药物

采用化学疗法治疗癌症是目前较为有效的方法之一。为了提高抗癌药物在体内的溶解性

增大药物在癌细胞内的累积量

增强对癌细胞的杀伤性

减小对正常组织细胞造成的毒害作用

抗癌药物载体从简单的抗癌药物-聚合物复合物、聚合物胶束、纳米粒子等简单结构逐渐向具有靶向性、环境刺激响应性、表面电荷反转性等特性的新型结构发展。本文综述了国内外抗癌药物载体的发展历程以及最新进展

着重对新型载体的制备和研究进行了论述。

Abstract

Cancer is one of the main reasons of the world' s high death rate. Chemical treatment would be the most effective way to remedy cancer. In order to promote the intracorporal dissolvability and intracellular cumulant of anticancer drugs

the destruction to cancer cells as well as to decrease the damage to normal tissues

the anticancer drug delivery system develops from simple carriers

like conjugations of anticancer drug and polymer

polymer micelles

simple nanoparticles

to advanced delivery system with properties of targeting

responding to environmental stimulation as well as charge reversal. This article mainly talks about the development progress of anticancer drug delivery system and highlights the preparation and theoretical research of new designed anticancer drug delivery system.

关键词

聚合物基抗癌药物载体

Keywords

PolymericAnticancerDrug delivery

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Related Institution

Beijing laboratory of biological materials, Beijing University of Chemical Technology

Beijing Research Institute of Traumatology and Orthopaedics

Beijing JiShuiTan Hospital, the Fourth Clinical Medical College of Peking University

Beijing Key Laboratory of the Preparation and Processing of Novel Polymer Materials

Department of macromolecular Science of Fudan University and the Key Laboratory of Molecular Engineering of Polymers, Ministry of Education

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