Synthesis and Characterization of Poly(ortho ester)

Yang-yang TAO; Kai GONG; Rui WANG; Ru-pei TANG

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Synthesis and Characterization of Poly(ortho ester)

更新时间：2022-09-18

- Synthesis and Characterization of Poly(ortho ester)
- Polymer Bulletin Vol. 26, Issue 6, Pages: 33-38(2013)
- 作者机构：
  
  江南大学药学院，无锡　215000
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013-06，
  
  Received：23 January 2013，
  
  Revised：04 March 2013，
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Yang-yang TAO, Kai GONG, Rui WANG, Ru-pei TANG. Synthesis and Characterization of Poly(ortho ester). [J]. Polymer Bulletin 26(6):33-38(2013)
DOI：

Yang-yang TAO, Kai GONG, Rui WANG, Ru-pei TANG. Synthesis and Characterization of Poly(ortho ester). [J]. Polymer Bulletin 26(6):33-38(2013) DOI：

摘要

以二聚甘油为原料

经过酯交换及氨基脱保护反应合成了一种两端含氨基的环状原酸酯新单体。该单体与辛二酸/十二烷二酸活性酯缩聚得到两种新的疏水性聚原酸酯共聚物POEAd-1和POEAd-2

其数均分子量分别由凝胶渗透色谱(GPC)测得为1. 24×10

及1. 81×10

分散度(PDI)分别为1. 59及1. 93。热失重分析法证实POEAd-1和POEAd-2具有较高的热稳定性能

其起始降解温度分别可达198. 5℃及202. 5℃。溶血试验和MTT细胞毒性试验表明

POEAd-1和POEAd-2均具有良好生物相容性

作为一种潜在的生物医用材料

在药物缓控释领域将具有广阔的应用前景。

Abstract

A new diamine monomercontaining a built-in

stabilized ortho ester group was synthesized by diglycerol with two steps of transesterification. Two new highly hydrophobic copolymer poly (ortho ester amide) (POEAd-1 and POEAd-2) were obtained by polycondensation ofthe monomer with suberic acid bis (N-hydroxysuccinimide ester) and dodecanedioic acid bis( N-hydroxysuccinimide ester). The number average molecular weight of POEAd-1 and POEAd-2 were determined by gel permeation chromatography (GPC)

and calculated to be 1.24 × 10

and. 1.81 × 10

with polydispersity index(PDI) of 1. 59 and 1.93

respectively. Thermal stabilityof POEAd-1 and POEAd-2 via thermogravimetric analysis ( TGA) were investigated)

the temperature of the onset 5 % weight loss is up to 198. 5℃ and 202. 5℃

respectively. Hemolysis test and MTT cytotoxicity test indicate that POEAd-1 and POEAd-2 has good biocompatibility as a potential biomedical materials

can bewidely used in the field of controlled drug deliever.

关键词

聚原酸酯生物医用材料生物相容性

Keywords

Poly(ortho ester)BiomaterialBiocompatibility

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