Study of the Amphiphilic Block Copolymer Self-assembly and the Drug-loaded Micelles

Qian-qian YOU; Huai-min ZHANG; Dan LI; Pu-yu ZHANG

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Study of the Amphiphilic Block Copolymer Self-assembly and the Drug-loaded Micelles

更新时间：2022-09-18

- Study of the Amphiphilic Block Copolymer Self-assembly and the Drug-loaded Micelles
- Polymer Bulletin Vol. 26, Issue 6, Pages: 51-56(2013)
- 作者机构：
  
  河南大学化学化工学院　精细化学与工程研究所，开封　475004
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013-06，
  
  Received：09 January 2013，
  
  Revised：03 February 2013，
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Qian-qian YOU, Huai-min ZHANG, Dan LI, Pu-yu ZHANG. Study of the Amphiphilic Block Copolymer Self-assembly and the Drug-loaded Micelles. [J]. Polymer Bulletin 26(6):51-56(2013)
DOI：

Qian-qian YOU, Huai-min ZHANG, Dan LI, Pu-yu ZHANG. Study of the Amphiphilic Block Copolymer Self-assembly and the Drug-loaded Micelles. [J]. Polymer Bulletin 26(6):51-56(2013) DOI：

摘要

采用可逆-加成-断裂链转移自由基聚合(RAFT)技术合成了两亲性嵌段共聚物聚苯乙烯-b-聚甲基丙烯酸聚乙二醇单甲醚-b-聚苯乙烯(PSt-b-POEOMA-b-PSt)

通过FT-IR、

HNMR、GPC确定共聚物的结构。将三个具有不同嵌段比的共聚物在水溶液中自组装

通过透射电子显微镜(TEM)观察得到的胶束的形貌

发现随着亲水性嵌段的比例减小

胶束的直径略微减小。通过透析方法

以共聚物作为载体

负载维生素E

TEM观察载药胶束的形貌

仍然为核-壳状的球形胶束。差示扫描量热仪(DSC)测试共聚物载药胶束前后的热性能

发现药物分子在载人内核的过程中

聚苯乙烯的玻璃化转变温度(T_g)有所降低。通过紫外(UV)分析计算得出共聚物的药物负载量(DLC)为70 % ~ 80%。

Abstract

Amphiphilic block copolymer Polystyrene-b-Poly(ethyleneoxide)monomethyl ethermethacrylate-b-Polystyrene (PSt-b-POEOMA-b-PSt) was synthesized by reversible addition fragmentation chain-transfer (RAFT) polymerization. The structure of the copolymer was characterized by FT-IR

HNMR

and GPC measurements. Three different ratio copolymers can readily be self-assembled into micelles in aqueous solution. It evidently observed the structure of micelles by transmission electron microscopy (TEM)

with the decrease in the proportion of hydrophilic segments

the micelle size decreased slightly. The drug loaded PSt-b-POEOMA-b-PSt micelles prepared by the dialysis method were then used carrier of liposoluble drug vitamin E

whose morphology was observed by TEM

and was still core-shell structure. The thermal properties of the drug-loaded micelles were observed by different scanning calorimetry (DSC). The results showed that the glass transition temperature (T_g) of polystyrene was reduced slightly in the process of loading VE to the kernel. The drug loading content (DLC) of the copolymers was 70 %-80 % by ultraviolet (UV) analysis.

关键词

RAFT聚合两亲性嵌段共聚物自组装胶束

Keywords

RAFT polymerizationAmphiphilic block copolymerSelf-assemblyMicelles

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