A Review of Biomedical Poly(lactic acid) Modification Research Progress

Xue-lian XIA; Wen-tao LIU; Li-na WANG; Su-qin HE; Cheng-shen ZHU

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A Review of Biomedical Poly(lactic acid) Modification Research Progress

更新时间：2022-09-18

- A Review of Biomedical Poly(lactic acid) Modification Research Progress
- Polymer Bulletin Vol. 26, Issue 11, Pages: 29-38(2013)
- 作者机构：
  
  郑州大学材料科学与工程学院，郑州　450052
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013-11，
  
  Received：09 April 2013，
  
  Revised：27 May 2013，
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Xue-lian XIA, Wen-tao LIU, Li-na WANG, Su-qin HE, Cheng-shen ZHU. A Review of Biomedical Poly(lactic acid) Modification Research Progress. [J]. Polymer Bulletin 26(11):29-38(2013)
DOI：

Xue-lian XIA, Wen-tao LIU, Li-na WANG, Su-qin HE, Cheng-shen ZHU. A Review of Biomedical Poly(lactic acid) Modification Research Progress. [J]. Polymer Bulletin 26(11):29-38(2013) DOI：

摘要

聚乳酸(polylactic acid)材料是一种用途广泛的可生物降解高分子材料

已经成为生物医用材料中最受重视的材料之一。但是聚乳酸也存在许多缺陷

限制了其在医药领域的广泛应用。本文综述了聚乳酸疏水性强、细胞亲和性差、力学性能不足

降解产物造成局部酸性积累而导致机体发生无菌性炎症反应

缺乏修复、降解、吸收速度与细胞的增殖、组织修复速度匹配的系列产品

成本高

均聚物成孔性能差等缺陷

总结了近些年国内外针对以上各个缺陷做出的改进方案

并对聚乳酸医用改性的研究发展方向进行了展望。

Abstract

Polylactic acid (PLA) is at present one of the most promising biodegradable polymers and has a wide range of applications. It has become one of the most important biomedical materials. But the PLA also has many disadvantages

which limits its application in the medicine field. In this paper

the strong hydrophobicity

poor cellular affinity

poor mechanical properties

aseptic inflammation reaction resulted from local accumulation of lactic acid produced by degradation products

lacking series products whose repair

degradation and absorption speed cannot well matched their cell proliferation and tissue repair speed

high cost

poor hole forming performance of homopolymer are reviewed. Summarized the scheme at home and abroad in recent years in view of the above various defects made

and the direction of research and development of PLA medical modification are discussed.Besides

the improvements made in recent years for each of the above defects are summarized. At last

the research and development orientation on PLA medical modification are prospected.

关键词

聚乳酸生物医用材料改性

Keywords

Poly(lactic acid)Biomedical materialsModification

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