Progress in Cyclodextrin-Based Nano-Drug Delivery Systems

Jing-xing SI; Shi-qun SHAO; You-qing SHEN; Mei-hua SUI

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Progress in Cyclodextrin-Based Nano-Drug Delivery Systems

更新时间：2022-09-18

- Progress in Cyclodextrin-Based Nano-Drug Delivery Systems
- Polymer Bulletin Vol. 26, Issue 11, Pages: 1-10(2013)
- 作者机构：
  
  1.浙江大学　化学工程与生物工程学系　生物纳米工程中心，杭州　310027
  2.浙江大学医学院附属第二医院，杭州　310009
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013-11，
  
  Received：14 June 2013，
  
  Revised：17 July 2013，
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Jing-xing SI, Shi-qun SHAO, You-qing SHEN, Mei-hua SUI. Progress in Cyclodextrin-Based Nano-Drug Delivery Systems. [J]. Polymer Bulletin 26(11):1-10(2013)
DOI：

Jing-xing SI, Shi-qun SHAO, You-qing SHEN, Mei-hua SUI. Progress in Cyclodextrin-Based Nano-Drug Delivery Systems. [J]. Polymer Bulletin 26(11):1-10(2013) DOI：

摘要

基于环糊精的纳米载药系统可分为含环糊精的聚合物纳米载体、双亲性环糊精纳米载体、疏水性环糊精纳米载体以及含环糊精的超分子复合物纳米载体。通过形成包含体复合物或环糊精/药物键合物等方式

这些纳米载药系统可以用于输送大分子及小分子药物

并能显著改善原药的理化和生物学性质

提高治疗效果

降低毒副作用。本文综述了近年来基于环糊精的纳米载药系统的研究进展。

Abstract

Cyclodextrin-based nano-drug delivery systems include cyclodextrin-containing polymers

amphiphilic cyclodextrins

hydrophobic cyclodextrins and cyclodextrin-based supermolecular complexes. These nano-drug delivery systems can serve as multi-functional drug carriers

through the formation of inclusion complex or the form of cyclodextrin-drug conjugate. Moreover

they may significantly improve the physicochemical and biological properties of the free drug

enhance the therapeutic efficiency and reduce toxic side effects. This article reviews the recent research progress in cyclodextrin-based nano-drug delivery systems.

关键词

环糊精包含体复合物环糊精/药物键合物药物输送

Keywords

CyclodextrinInclusion complexDrug-cyclodextrin conjugateDrug delivery

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