owns the perfect structural symmetry and unique physical and chemical properties. It is believed that C
60
has much potential in biomedical
superconductivity
optics and catalysis and so on. But its poor solubility in water and compatibility with the organism limit its application. So people synthesize a variety of water-soluble C
60
derivatives and study their application. This article mainly reviews the research of water-soluble C
60
derivatives in the biomedical field for recent years
including cancer treatment
drug or gene carrier
antioxidation
interaction with enzymes
cytotoxicity. In addition
the study prospects on these derivatives are also included.