Kinetic Study on the Complexation of DNA/RNA with Polycations

Ji-han ZHOU; Lin NIU; De-hai LIANG

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Kinetic Study on the Complexation of DNA/RNA with Polycations

更新时间：2022-09-18

- Kinetic Study on the Complexation of DNA/RNA with Polycations
- Polymer Bulletin Vol. 27, Issue 8, Pages: 34-43(2014)
- 作者机构：
  
  北京大学化学与分子工程学院，高分子化学与物理教育部重点实验室，北京　100871
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2014-08，
  
  Received：12 May 2014，
  
  Revised：23 May 2014，
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Ji-han ZHOU, Lin NIU, De-hai LIANG. Kinetic Study on the Complexation of DNA/RNA with Polycations. [J]. Polymer Bulletin 27(8):34-43(2014)
DOI：

Ji-han ZHOU, Lin NIU, De-hai LIANG. Kinetic Study on the Complexation of DNA/RNA with Polycations. [J]. Polymer Bulletin 27(8):34-43(2014) DOI：

摘要

DNA或RNA与聚阳离子形成的复合物被广泛用作非病毒类基因载体。由于静电相互作用的高强度和长程性，在溶液中形成的DNA/RNA复合物往往受动力学控制，其结构随着时间会进一步变化。本文总结了这些年来DNA/RNA与聚阳离子复合形成的复合物动力学研究进展，并提出影响复合物的因素主要有两个：近程静电吸引力和远程静电排斥力之间的竞争，以及复合物内、复合物之间的歧化。揭示DNA/RNA与聚阳离子的复合机理，对于制备具有特定结构和功能的基因载体具有重要意义。

Abstract

The complexes formed by DNA or RNA interacting with polycations have been widely used as non-viral gene vectors. Owing to the strong and long-ranged electrostatic interaction

the complex is usually controlled by kinetics and its structure evolves with time. This review summarized the recent studies on kinetics of the complexation between DNA/RNA with polycations. We proposed that the major factors determining the kinetics of complexation were the balance between the long-ranged electrostatic repulsion force and the short-ranged electrostatic attraction forces

as well as the intra- and inter- complex disproportionation rate. The disclosure of the complexation mechanism is helpful in developing high performance gene delivery vectors.

关键词

DNA/RNA复合物基因传递载体动力学

Keywords

DNA/RNAComplexGene deliveryKinetics

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