Sequence-regulated polymerization is the Holy Grail of polymer science

which paves the way towards hierarchical structures and sophisticated functions. The ultimate goals of sequence-regulated polymerization are to develop new polymerization methods to precisely control the polymer chain microstructures

to get insight on the polymer structure ind property relationship; to deeply understand the intramolecular interaction of a single polymer chain as well as polymer chain interactions

and finally to realize the controlled single polymer chain folding and precise self-assembly of several )olymer chains as well as develop new functional polymeric materials. Recent progress of in biomacromolecule synthesis

templated polymerization

solid-phase synthesis

chain-growth polymerization as well as step-growth polymerization is highlighted. Moreover

we outlook the future direction of ultra-precise and highly efficient sequence regulation nethodology

and the effect of sequenced microstructures on material properties.