Research Progress in Interaction between Nanotopography of Tissue Engineering Scaffolds and Cells

Xiao-xia CHENG; Ai-zheng CHEN; Shi-bin WANG

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Research Progress in Interaction between Nanotopography of Tissue Engineering Scaffolds and Cells

更新时间：2022-09-18

- Research Progress in Interaction between Nanotopography of Tissue Engineering Scaffolds and Cells
- Polymer Bulletin Vol. 27, Issue 10, Pages: 109-115(2014)
- 作者机构：
  
  华侨大学化工学院，华侨大学生物材料与组织工程研究所，厦门　361021
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2014-10，
  
  Received：03 April 2014，
  
  Revised：23 May 2014，
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Xiao-xia CHENG, Ai-zheng CHEN, Shi-bin WANG. Research Progress in Interaction between Nanotopography of Tissue Engineering Scaffolds and Cells. [J]. Polymer Bulletin 27(10):109-115(2014)
DOI：

Xiao-xia CHENG, Ai-zheng CHEN, Shi-bin WANG. Research Progress in Interaction between Nanotopography of Tissue Engineering Scaffolds and Cells. [J]. Polymer Bulletin 27(10):109-115(2014) DOI：

摘要

为解决传统方法治疗组织缺损中免疫排斥、供体不足等问题，性能优异的生物仿生支架近年来受到广泛关注。大量研究显示，组织工程支架的纳米拓扑结构会对细胞行为产生重要的影响。本文综述了支架的不同结构、支架纤维的直径及排列方式、支架的孔洞尺寸等纳米拓扑结构对细胞粘附、增殖、迁移、蛋白分泌及分化方向等行为的影响；总结了支架纳米拓扑结构对细胞影响的可能机制；同时，对支架拓扑结构影响细胞的系统理论研究及多孔纤维支架的制备进行了展望。

Abstract

Traditional therapeutics for tissue defection suffer fromimmune rejection and shortage of donor organs

thus much attention has been paid to bionic scaffolds with excellent performances for tissue engineering recently. It has been proven that the nanotopography of tissue engineering scaffold has a great impact on cell behaviors. This article mainly reviews the influence of scaffold nanotopography

including the different structures

fiber diameters

fiber orientations and porous sizes

on cell adherence

proliferation

migration

protein secretion

and differentiation direction. The possible mechanisms of interaction between nanotopography of tissue engineering scaffolds and cells are summarized. Meanwhile

the prospect is also presented from two aspects : research on systematic theory for the impact of scaffold nanotopography on cells and construction of porous-fiber-formed scaffold.

关键词

组织工程支架纳米拓扑结构细胞相互作用

Keywords

Tissue engineeringScaffoldsNanotopographyCellsInteraction

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