The Controlled-Release Properties of Chitosan Hydrogels with Phosphorylcholine Groups

Ming GONG; Cheng-jian SONG; Jian-lin QU; Guang-heng WANG; Wei YU; Yong-kuan GONG

doi:10.14028/j.cnki.1003-3726.2015.05.007

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The Controlled-Release Properties of Chitosan Hydrogels with Phosphorylcholine Groups

更新时间：2022-09-18

- The Controlled-Release Properties of Chitosan Hydrogels with Phosphorylcholine Groups
- Polymer Bulletin Vol. 28, Issue 5, Pages: 56-60(2015)
- 作者机构：
  
  1.西安科技大学化学与化工学院，西安　710054
  2.西北大学合成与天然功能分子化学教育部重点实验室化学与材料科学学院，西安　710069
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2015.05.007
  CLC：
- Published：2015-05，
  
  Received：08 July 2014，
  
  Revised：11 December 2014，
扫描看全文
Ming GONG, Cheng-jian SONG, Jian-lin QU, Guang-heng WANG, Wei YU, Yong-kuan GONG. The Controlled-Release Properties of Chitosan Hydrogels with Phosphorylcholine Groups. [J]. Polymer Bulletin 28(5):56-60(2015)
DOI：

Ming GONG, Cheng-jian SONG, Jian-lin QU, Guang-heng WANG, Wei YU, Yong-kuan GONG. The Controlled-Release Properties of Chitosan Hydrogels with Phosphorylcholine Groups. [J]. Polymer Bulletin 28(5):56-60(2015) DOI： 10.14028/j.cnki.1003-3726.2015.05.007.

摘要

壳聚糖(CS)是自然界中唯一的聚阳离子碱性多糖

具有良好的组织相容性、生物可降解性、无毒、无刺激、pH响应性等优点

因而在药物控释领域的具有潜在的应用价值。将聚阳离子壳聚糖与聚阴离子甲基丙烯酰氧乙基磷酰胆碱-甲基丙烯酸二元共聚物(poly(MPC-co-MA)

PMA30)进行静电复合

制备CS-PMA30聚离子水凝胶。以考马斯亮蓝为模型药物

对CS-PMA30水凝胶的控释性能进行研究。结果表明

该CS-PMA30体系是通过静电作用形成的物理交联水凝胶

具有pH响应性

有望在药物控释、组织工程等领域得到广泛应用。

Abstract

Chitosan (CS) is a polycationic biopolymer

one of the most abundant natural polysaccharides in nature. With numerous desirable properties such as good biocompatibility

biodegradability

pH response

non-toxicity and no stimulation to human tissues

chitosan has emerged as a promising drug delivery. The PMA30 was synthesized by free radical polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) and methacrylic acid (MA) with the MPC monomer molar percentage in the feed of 30%. The CS-PMA30 polyelectrolyte hydrogel was prepared through electrostatic interaction between chitosan polycation and PMA30 polyanions. In vitro drug release of coomassie brilliant blue G-250 from the CS-PMA30 hydrogel was determined by dialysis method. The results suggest that the CS-PMA30 hydrogel with phosphorylcholine groups is a good system for drug delivery due to pH-sensitive and biocompatibility may have potential applications in the fields of drug delivery

and tissue engineering.

关键词

壳聚糖水凝胶磷酰胆碱控释性能

Keywords

ChitosanPhosphorylcholineHydrogelControlled release

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