Synthesis of Functionalized Poly(ε-caprolactone)s and their Biological Applications

Jun ZHANG; Yan XIAO; Heng XU; Jin-liang YAN; Mei-dong LANG

doi:10.14028/j.cnki.1003-3726.2016.05.003

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Synthesis of Functionalized Poly(ε-caprolactone)s and their Biological Applications

更新时间：2022-09-12

- Synthesis of Functionalized Poly(ε-caprolactone)s and their Biological Applications
- Polymer Bulletin Vol. 29, Issue 5, Pages: 13-26(2016)
- 作者机构：
  
  1.华东理工大学材料科学与工程学院，上海 200237
  2.石油化工新材料协同创新中心，安庆 246011
  3.上海生物制造产业协同创新中心，上海 200237
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2016.05.003
  CLC：
- Published：20 May 2016，
  
  Received：29 May 2015，
  
  Revised：29 September 2015，
扫描看全文
Jun ZHANG, Yan XIAO, Heng XU, Jin-liang YAN, Mei-dong LANG. Synthesis of Functionalized Poly(ε-caprolactone)s and their Biological Applications. [J]. Polymer Bulletin 29(5):13-26(2016)
DOI：

Jun ZHANG, Yan XIAO, Heng XU, Jin-liang YAN, Mei-dong LANG. Synthesis of Functionalized Poly(ε-caprolactone)s and their Biological Applications. [J]. Polymer Bulletin 29(5):13-26(2016) DOI： 10.14028/j.cnki.1003-3726.2016.05.003.

摘要

聚己内酯（PCL）是一种疏水的、半结晶的、可降解的脂肪族聚合物，其具有良好的生物相容性、药物透过性和机械性能，在药物缓释和组织工程领域得到了广泛的关注。由于其结晶性强，亲水性差，生物降解速度慢，限制了其在生物医用领域更广泛的应用。聚己内酯的官能团化可实现对聚酯材料亲疏水性、降解速率等物化性质的调节，同时，活性官能团的引入便于对PCL的进一步化学修饰，有利于拓宽聚己内酯类材料的生物医用领域。本文详细介绍在聚己内酯骨架引入侧基官能团的化学方法，并简要阐述了官能团化聚己内酯在生物医用材料领域的应用。

Abstract

Polycaprolactone ( PCL) is a hydrophobic

semi-crystalline and biodegradable aliphatic polymer. A good biocompatibility and mechanical properties of PCL has stimulated extensive attention in the drug delivery and tissue engineering. However

the major drawback of the PCL is highly crystalline

low hydrophilic and slow biodegradation which limited its widely application in the biomedical field. The introduction of functional groups into commonly used PCL make it possible to further chemical modification as well as tune its physicochemical properties such as hydrophilicity and degradation rate

which makes PCL more suitable for biomedical applications. This review will focus on the prepared method of PCL with pendent functional groups

and briefly discussed its application in the biomedical areas.

关键词

聚己内酯官能团化药物缓释组织工程

Keywords

PCLFunctionalDrug deliveryTissue engineering

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