Methodology of in situ Detection of Degradation of Polymeric Biomedical Materials

Yong-li QI; Ke-wen LEI; Lin YU; Jian-dong DING

doi:10.14028/j.cnki.1003-3726.2016.05.005

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Methodology of in situ Detection of Degradation of Polymeric Biomedical Materials

更新时间：2022-09-12

- Methodology of in situ Detection of Degradation of Polymeric Biomedical Materials
- Polymer Bulletin Vol. 29, Issue 5, Pages: 43-51(2016)
- 作者机构：
  
  聚合物分子工程国家重点实验室，复旦大学高分子科学系，上海 200433
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2016.05.005
  CLC：
- Published：20 May 2016，
  
  Received：23 September 2015，
  
  Revised：23 December 2015，
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Yong-li QI, Ke-wen LEI, Lin YU, Jian-dong DING. Methodology of in situ Detection of Degradation of Polymeric Biomedical Materials. [J]. Polymer Bulletin 29(5):43-51(2016)
DOI：

Yong-li QI, Ke-wen LEI, Lin YU, Jian-dong DING. Methodology of in situ Detection of Degradation of Polymeric Biomedical Materials. [J]. Polymer Bulletin 29(5):43-51(2016) DOI： 10.14028/j.cnki.1003-3726.2016.05.005.

摘要

可降解高分子材料在骨科内固定、药物缓控释载体、组织工程支架、心血管支架等领域均有重要应用。为使材料的降解速率、力学性能与实际应用之间相匹配，需要对材料的降解行为有清晰的了解。早期对材料降解行为的研究主要采取定期取样测质量变化等方法，需消耗大量的样品和动物。为解决这个问题，一些新型成像技术被用于原位探测材料的降解行为，从而实现对同一个样品的连续监测。本文综述了近年来采用原位法研究可降解高分子材料降解行为的进展情况，侧重荧光成像法、光声及超声成像法和电化学方法。

Abstract

Biodegradable polymers are widely applied in medicine such as orthopedic internal fixation

controlled/ sustained drug release

tissue engineering scaffolds

and cardiovascular stents. Appropriate biodegradation is critical for those medical applications. A classical detection of biodegradation requires a large number of material samples and animals. Alternatively

some imaging techniques have been explored for non-invasive assessment of the degradation profile of an individual sample in situ. This review summarizes the recent advances in the field of in situ and non-invasive characterization of biodegradable polymeric materials

with emphasis of fluorescence imaging

photoacoustic/ultrasound imaging

and electrochemical method.

关键词

医用高分子生物可降解荧光成像法光声及超声成像法电化学方法

Keywords

Biomedical polymerBiodegradableFluorescence imagingPhotoacoustic and ultrasound imagingElectrochemical method

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Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology

Deparment of Polymer Paterials, Materials Mnstitute of Shanghai University

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