Investigation on the Biocompatibility of Poly(trimethylene carbonate)

Qun-hua ZHOU; Li-qun YANG; Wei ZHANG; Miao LI; Feng-li LI

doi:10.14028/j.cnki.1003-3726.2016.06.010

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Investigation on the Biocompatibility of Poly(trimethylene carbonate)

更新时间：2022-09-12

- Investigation on the Biocompatibility of Poly(trimethylene carbonate)
- Polymer Bulletin Vol. 29, Issue 6, Pages: 71-77(2016)
- 作者机构：
  
  1.郑州澍青医学高等专科学校，郑州 450064
  2.辽宁省计划生育科学研究院，沈阳 110031
  3.国家卫生和计划生育委员会生殖健康与遗传医学重点实验室，沈阳 110031
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2016.06.010
  CLC：
- Published：20 June 2016，
  
  Received：30 December 2015，
  
  Revised：18 March 2016，
扫描看全文
Qun-hua ZHOU, Li-qun YANG, Wei ZHANG, Miao LI, Feng-li LI. Investigation on the Biocompatibility of Poly(trimethylene carbonate). [J]. Polymer Bulletin 29(6):71-77(2016)
DOI：

Qun-hua ZHOU, Li-qun YANG, Wei ZHANG, Miao LI, Feng-li LI. Investigation on the Biocompatibility of Poly(trimethylene carbonate). [J]. Polymer Bulletin 29(6):71-77(2016) DOI： 10.14028/j.cnki.1003-3726.2016.06.010.

摘要

以实验室自制的聚三亚甲基碳酸酯（PTMC）为研究对象，通过测定聚三亚甲基碳酸酯在体外酶解过程中降解液pH变化，考察其在降解过程中是否产生酸性降解产物；通过MTS法考察聚三亚甲基碳酸酯的体外细胞毒性；通过HE染色的方法考察聚三亚甲基碳酸酯在大鼠体内埋植部位的皮肤刺激性，进而考察聚三亚甲基碳酸酯的生物相容性。结果表明：PTMC在降解过程中不产生酸性降解产物，可避免埋植部位无菌炎症的产生。同时不同分子量的PTMC可以存在于皮下组织而不会造成伤害，因此聚三亚甲基碳酸酯具有良好的生物相容性，可安全植入体内。

Abstract

The PTMC rods were directly synthesized via a bulk ring-opening polymerization reaction of TMC in the presence of Sn(Oct)

as the catalys. The pH of the media before and after degradation was monitored with a combination microelectrode (InLabMicro

Toledo-Mettler) and a digital pH meter (FiveEasy

Toledo-Mettler). The potential cytotoxicity of the PTMC rods was evaluated using an MTS assay. For one polymer at each study time point

six specimens were implanted bilaterally into the subcutaneous tissue of the back of one rat. After implantation

the Histology of the polymers was evaluated by H

E. The results showed that PTMC can be degraded without the formation of the acidic degradation products

and all the PTMC rods can thus be considered non-cytotoxic with no adverse effects on cell viability. In addition

the PTMC rods are able to coexist with subcutaneous tissues without causing harm

regardless of their initial molecular weight. Thus

the PTMC rods are considered to have good biocompatible and safe for in vivo implantation.

关键词

聚三亚甲基碳酸酯生物相容性细胞毒性pH聚三亚甲基碳酸酯生物相容性细胞毒性pH

Keywords

Poly (trimethylene carbonate)BiocompatibilityCytotoxicitypHPoly (trimethylene carbonate)BiocompatibilityCytotoxicitypH

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