Preparation of Biodegradable Gestodene Sustained-release Implants and Drug Release in Vitro

Wei ZHANG; Li-qun YANG; Shu MENG; Jian-xin LI; Ying JIN; Dong-xu YI

doi:10.14028/j.cnki.1003-3726.2016.07.010

您当前的位置：

首页 >

文章列表页 >

Preparation of Biodegradable Gestodene Sustained-release Implants and Drug Release in Vitro

更新时间：2022-09-12

- Preparation of Biodegradable Gestodene Sustained-release Implants and Drug Release in Vitro
- Polymer Bulletin Vol. 29, Issue 7, Pages: 78-81(2016)
- 作者机构：
  
  辽宁省计划生育科学研究院，沈阳 110031
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2016.07.010
  CLC：
- Published：20 July 2016，
  
  Received：03 December 2015，
  
  Revised：15 March 2016，
扫描看全文
Wei ZHANG, Li-qun YANG, Shu MENG, Jian-xin LI, Ying JIN, Dong-xu YI. Preparation of Biodegradable Gestodene Sustained-release Implants and Drug Release in Vitro. [J]. Polymer Bulletin 29(7):78-81(2016)
DOI：

Wei ZHANG, Li-qun YANG, Shu MENG, Jian-xin LI, Ying JIN, Dong-xu YI. Preparation of Biodegradable Gestodene Sustained-release Implants and Drug Release in Vitro. [J]. Polymer Bulletin 29(7):78-81(2016) DOI： 10.14028/j.cnki.1003-3726.2016.07.010.

摘要

以聚己内酯(PCL)为载体材料，采用双螺杆挤出工艺制备了孕二烯酮缓释植入剂。采用凝胶渗透色谱仪(GPC)测定分子量，扫描电镜（SEM)观察结构，红外光谱分析（FT-IR)分析药物载体状态，紫外分光光度法(UV)测定植入剂的载药量和药物释放情况。结果表明：挤出后载体分子量无明显变化；挤出工艺对载药植入剂成形性好，表面无药物析出；药物与载体以物理混合方式存在；该植入剂在体外可长效释药，趋于一级药物释放模式(

=0. 9948)。

Abstract

The gestodene sustained-release implants were prepared by twin-screw extrusion process with poly (ε-caprolactone) as a carrier. The molecular weight was investigated by Gel permeation chromatography (GPC) and the structure of the implant was observed by Scanning electron microscopy(SEM) and the state of the drug dispersed in the poly (ε-caprolactone) was measured by Fourier transform infrared spectroscopy (FT-IR). The drug loading content and the accumulative release ratio were determined by Ultraviolet spectrophotometry(UV). The results showed that the molecular weight had no obvious change after extrusion. The drug loaded implants were fabricated successfully and the drug did not precipitate on the surface of the drug loaded implants. The drug loaded implant was a physical mixture of drug and carrier. The drug release profile was long-term sustained and fit the first order equation well in vitro(

=0. 9948).

关键词

孕二烯酮聚己内酯缓释植入剂体外药物释放

Keywords

GestodenePoly(ε-caprolactone)Sustained-release implantsDrug release in vitro

references

更多指标>

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The Study on Structure and Properties of Poly(ε-caprolactone)/CeO₂ Hybrid Fibers by Electrospinning

Related Author

No data

Related Institution

Academy of Material and Chemical Engineering,Henan Institute of Engineering

Department of tourism management,Henan University of Animal Husbandry and Economy

⁰