Preparation and Application of Star Porphyrinized Poly(<italic style="font-style: italic">N</italic>-isopropylacrylamide)

Chang-ling LIU; Cui XIAO; Chang-ming DU; Yan SONG

doi:10.14028/j.cnki.1003-3726.2021.02.009

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Preparation and Application of Star Porphyrinized Poly(N-isopropylacrylamide)

更新时间：2022-08-30

- Preparation and Application of Star Porphyrinized Poly(N-isopropylacrylamide)
- Polymer Bulletin Vol. 34, Issue 2, Pages: 70-77(2021)
- 作者机构：
  
  1.吉林化工学院材料科学与工程学院,吉林 132022
  2.中油吉林石化公司研究院,吉林 132022
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2021.02.009
  CLC：
- Published：20 February 2021，
  
  Received：22 May 2020，
  
  Revised：07 December 2020，
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Chang-ling LIU, Cui XIAO, Chang-ming DU, Yan SONG. Preparation and Application of Star Porphyrinized Poly(N-isopropylacrylamide). [J]. Polymer Bulletin 34(2):70-77(2021)
DOI：

Chang-ling LIU, Cui XIAO, Chang-ming DU, Yan SONG. Preparation and Application of Star Porphyrinized Poly(N-isopropylacrylamide). [J]. Polymer Bulletin 34(2):70-77(2021) DOI： 10.14028/j.cnki.1003-3726.2021.02.009.

摘要

近几年来

卟啉化合物因其独特的光电化学性质

被广泛地应用于光动力学疗法(PDT)中。然而

绝大多数卟啉基化合物水溶性差

易发生低分子聚集分散不均的现象

限制其在PDT的应用。因此

利用卟啉化合物易于被修饰的特点

通过可逆加成裂解链转移自由基聚合法将含有—OH 的卟啉与

-异丙基丙烯酰胺单体聚合形成温敏性聚合物(THPP-PAM

)。并对其温敏性进行了研究

研究表明该共聚物的LCST值在32℃

MTT测试结果显示THPP-PAM

具有良好的生物相容性

对L929细胞和HeLa细胞的暗毒性较低

对HeLa细胞的光毒性明显高于对L929细胞毒性。

Abstract

In recent years

porphyrin compounds have been widely used in photodynamic therapy (PDT) due to their unique photoelectrochemical properties.However

most porphyrin-based compounds have poor water solubility and are prone to uneven distribution of low-molecular aggregation

which limits their application in PDT. Therefore

this article takes advantage of the fact that porphyrin compounds are easily modified

and polymerizes —OH-containing porphyrin with

-isopropylacrylamide monomer to form a temperature-sensitive polymer (THPP) by reversible addition cleavage chain transfer radical polymerization-PAM

). The temperature sensitivity of the copolymer was studied. The study showed that the copolymer had an LCST value of 32℃. The MTT test results showed that THPP-PAM

has good biocompatibility and low dark toxicity to L929 cells and

HeLa

cells. The phototoxicity to HeLa cells was significantly higher than that to L929 cells.

关键词

卟啉可逆加成裂解链转移自由基聚合温度响应性最低临界溶解温度生物相容性

Keywords

PorphyrinReversible addition cleavage chain transfer radical polymerizationTemperature responsivenessMinimum critical solution temperatureBiocompatibility

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Related Institution

Research Institute of Natural Gas Technology, Southwest Oil & Gas-field Company, CNPC

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State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences

Zhengzhou Shuqing Medical College

⁰

Preparation and Application of Star Porphyrinized Poly(N-isopropylacrylamide)

DOI：10.14028/j.cnki.1003-3726.2021.02.009

摘要

Abstract

关键词

Keywords

references