Preparation of Cyclodextrin-Chitosan/Carboxymethyl Cellulose Hydrogel and Study on its Slow Release Property

Shao-fei ZHANG; Wen-bin HU; Du-liu WANG; Xiao-chun YIN; Rong-min WANG; Ru-yan JIA

doi:10.14028/j.cnki.1003-3726.2021.04.006

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Preparation of Cyclodextrin-Chitosan/Carboxymethyl Cellulose Hydrogel and Study on its Slow Release Property

更新时间：2022-08-30

- Preparation of Cyclodextrin-Chitosan/Carboxymethyl Cellulose Hydrogel and Study on its Slow Release Property
- Polymer Bulletin Vol. 34, Issue 4, Pages: 43-49(2021)
- 作者机构：
  
  1.农林技术学院,陇南师范高等专科学校,陇南 742500
  2.公共卫生学院,甘肃中医药大学,甘肃兰州 730000
  3.生态环境相关高分子材料教育部重点实验室,化学化工学院,西北师范大学,兰州 730070
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2021.04.006
  CLC：
- Published：20 April 2021，
  
  Received：26 March 2020，
  
  Revised：18 January 2021，
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Shao-fei ZHANG, Wen-bin HU, Du-liu WANG, Xiao-chun YIN, Rong-min WANG, Ru-yan JIA. Preparation of Cyclodextrin-Chitosan/Carboxymethyl Cellulose Hydrogel and Study on its Slow Release Property. [J]. Polymer Bulletin 34(4):43-49(2021)
DOI：

Shao-fei ZHANG, Wen-bin HU, Du-liu WANG, Xiao-chun YIN, Rong-min WANG, Ru-yan JIA. Preparation of Cyclodextrin-Chitosan/Carboxymethyl Cellulose Hydrogel and Study on its Slow Release Property. [J]. Polymer Bulletin 34(4):43-49(2021) DOI： 10.14028/j.cnki.1003-3726.2021.04.006.

摘要

首先通过壳聚糖(CS)、柠檬酸(CA)和环糊精(β-CD)制备了环糊精接枝壳聚糖载体(CS-CA-β-CD);然后将CS-CA-β-CD与羧甲基纤维素(CMC)共混制备了环糊精-壳聚糖/羧甲基纤维素水凝胶(CS-CA-β-CD/CMC)

利用红外光谱(FTIR)、Zeta电位和透射电镜(TEM)对其结构进行表征;最后将其负载扑热息痛(Pa)进行释放性能研究

研究结果表明:这种药物载体对扑热息痛的载药量为76%、包封率为38%;对比环糊精接枝壳聚糖载体负载扑热息痛(CS-CA-β-CD/Pa)

CS-CA-β-CD/CMC负载扑热息痛后的药物(CS-CA-β-CD/CMC/Pa)具有更好的缓慢释放性能。因此

CS-CA-β-CD/CMC/Pa药物在风湿性关节炎疼痛缓解治疗中具有一定的应用前景。

Abstract

Firstly

the carrier of chitosan grafted with cyclodextrin (CS-CA-β-CD) was prepared by chitosan (CS)

citric acid (CA) and cyclodextrin (β-CD). Then

cyclodextrin-chitosan/carboxymethyl cellulose hydrogel (CS-CA-β-CD/ CMC) was prepared by CS-CA-β-CD blend with carboxymethyl cellulose (CMC)

the structure was characterized by infrared spectroscopy (FTIR)

Zeta potential and transmission electron microscope (TEM). Lastly

the release performance of paracetamol (Pa) was studied

the results showed that the drug carrier had a drug load of 76% and a encapsulation rate of 38% for paracetamol. Compared with CS-CA-β-CD/Pa

the drug (CS-CA-β-CD/CMC/Pa) had better slow release performance. Therefore

CS-CA-β-CD/CMC/Pa has a certain application prospect for the pain relief treatment of rheumatoid arthritis.

关键词

壳聚糖环糊精羧甲基纤维素缓释

Keywords

ChitosanCyclodextrinCarboxymethyl celluloseSlow release

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