Material Properties and Progress in Modification of PMMA Bone Cement

LIU Yuan-biao; GUO Kai; JIAO En-xiang; XU Shan-shan; YANG Jian-hui; LI Wen-ju; LIU Guo-hua; ZHAO Liang; ZHANG Hai-jun

doi:10.14028/j.cnki.1003-3726.2023.12.003

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Material Properties and Progress in Modification of PMMA Bone Cement

更新时间：2023-11-23

- Material Properties and Progress in Modification of PMMA Bone Cement
- Polymer Bulletin Vol. 36, Issue 12, Pages: 1610-1633(2023)
- 作者机构：
  
  1.山东理工大学材料科学与工程学院，淄博　255000
  2.生物医用材料改性技术国家地方联合工程实验室，德州　251100
  3.同济大学介入血管研究所，上海　200072
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2023.12.003
  CLC：
- Published：20 December 2023，
  
  Received：22 February 2023，
  
  Revised：18 April 2023，
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LIU Yuan-biao, GUO Kai, JIAO En-xiang, XU Shan-shan, YANG Jian-hui, LI Wen-ju, LIU Guo-hua, ZHAO Liang, ZHANG Hai-jun. Material Properties and Progress in Modification of PMMA Bone Cement. [J]. Polymer Bulletin 36(12):1610-1633(2023)
DOI：

LIU Yuan-biao, GUO Kai, JIAO En-xiang, XU Shan-shan, YANG Jian-hui, LI Wen-ju, LIU Guo-hua, ZHAO Liang, ZHANG Hai-jun. Material Properties and Progress in Modification of PMMA Bone Cement. [J]. Polymer Bulletin 36(12):1610-1633(2023) DOI： 10.14028/j.cnki.1003-3726.2023.12.003.

摘要

传统聚甲基丙烯酸甲酯(polymethyl methacrylate

PMMA)骨水泥在人工关节置换术、经皮穿刺椎体成形术、球囊扩张椎体后凸成形术等骨修复技术中得到广泛应用。不过

PMMA 骨水泥具有反应产热高、单体毒性大、骨传导和骨诱导能力差、生物活性弱、弹性模量过高等缺点

这些弊端一定程度上限制了PMMA 的临床应用前景。因此

对 PMMA 骨水泥进行改性

改善 PMMA 的力学性能

增强其生物活性以及与骨组织的骨性键接

已成为目前骨组织修复领域的研究焦点。本文将针对PMMA 骨水泥的改性研究进展进行综述

介绍改善PMMA骨水泥生物性能和机械性能的有效方法

并对未来PMMA骨水泥的研究方向展开讨论。

Abstract

Traditional polymethyl methacrylate (PMMA) bone cement has been widely adopted in bone repair technics such as artificial joint replacement

percutaneous vertebroplasty and kyphoplasty

etc. However

PMMA bone cement is typically endowed with high polymeric heat

high monomer toxicity

poor osteoconductive and osteoinductive ability

weak bioactivity

and extremely high elastic modulus

which limit the clinical application prospects of PMMA bone cement. Therefore

the modification of PMMA bone cement

devoted to enhancing its mechanical properties

bioactivity and bone bonding capability

has become a hot topic in the field of bone tissue reconstruction. This paper will review the modification progress of PMMA bone cement and introduce the effective methods that improve the biological and mechanical properties of PMMA matrix

and discuss the future research direction of PMMA bone cement.

关键词

骨水泥生物活性弹性模量骨传导骨诱导

Keywords

Bone cementBioactivityElastic modulusOsteoconductiveOsteoinductive

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