Studies on Natural Polysaccharides Used as Nucleic Acid Carriers

ZHANG Man; MU Dan; ZHANG Ping; SU Ri-na

doi:10.14028/j.cnki.1003-3726.2024.23.163

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Studies on Natural Polysaccharides Used as Nucleic Acid Carriers

更新时间：2024-02-06

- Studies on Natural Polysaccharides Used as Nucleic Acid Carriers
- Polymer Bulletin Vol. 37, Issue 3, Pages: 297-308(2024)
- 作者机构：
  
  内蒙古医科大学，呼和浩特 010010
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2024.23.163
  CLC：
- Received：10 May 2023，
  
  Accepted：26 July 2023，
  
  Published：20 March 2024
- 稿件说明：
移动端阅览
张曼, 牧丹, 张屏, 苏日娜. 天然多糖作为核酸载体的研究. 高分子通报, 2024, 37(3), 297–308

Zhang, M.; Mu, D.; Zhang, P.; Su, R. N. Studies on natural polysaccharides used as nucleic acid carriers. Polym. Bull. (in Chinese), 2024, 37(3), 297–308
张曼, 牧丹, 张屏, 苏日娜. 天然多糖作为核酸载体的研究. 高分子通报, 2024, 37(3), 297–308 DOI： 10.14028/j.cnki.1003-3726.2024.23.163.

Zhang, M.; Mu, D.; Zhang, P.; Su, R. N. Studies on natural polysaccharides used as nucleic acid carriers. Polym. Bull. (in Chinese), 2024, 37(3), 297–308 DOI： 10.14028/j.cnki.1003-3726.2024.23.163.

摘要

基因治疗这种堪称革命性的治疗方法，开拓了治疗癌症的新思路

其最关键性问题是实现核酸药物靶向肿瘤组织并精准治疗。核酸药物直接递送存在核酸酶降解代谢、细胞膜上的负电荷排斥现象以及稳定性差等问题，所以核酸药物需要载体协助，成功的载体递送除能使核酸药物在肿瘤区域大量富集外，还要起到药物控释作用，而天然多糖除无毒、生物相容度高、易修饰的特点外，它本身就具有免疫调节、抗肿瘤、抗炎等多种生物活性。本篇总结了最具代表性的五种多糖的结构特征及在核酸药物递送方面的应用，继而归纳了多糖的常用的纳米级载体形式，为构建天然多糖递送核酸的新型载体并将其应用到免疫抗肿瘤治疗研究中奠定基础。

Abstract

Gene therapy

a revolutionary treatment method

has opened up a new way of thinking in the treatment of cancer. The most critical problem of gene therapy is the realization of nucleic acid drugs targeting tumor tissues and precise treatment. Direct delivery of nucleic acid drugs has the problems of nuclease degradation and metabolism

negative charge rejection on cell membrane and poor stability

so nucleic acid drugs need the assistance of the carrier. Successful carrier delivery can not only enrich nucleic acid drugs in tumor areas

but also play the role of drug controlled release. Natural polysaccharide is non-toxic

biocompatibe

elasy to modify

and has immunomodulatory

anti-tumor

anti-inflammatory and other biological activities. This review summarizes the structural characteristics of the five most representative polysaccharides and their applications in nucleic acid drug delivery

and then describes the common nanoscale carrier forms of polysaccharides

which lays a foundation for the construction of a new nucleic acid delivery system based on natural polysaccharides and its application in immunoantitumor therapy.

关键词

Keywords

references

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