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Research Progress on Natural Polymer Antibacterial Hydrogel Wound Dressings
- Polymer Bulletin Vol. 37, Issue 10, Pages: 1337-1353(2024)
- 作者机构：
1.聊城大学生物制药研究院，聊城 252059
2.聊城高新生物技术有限公司，聊城 252059
- 作者简介：
- 基金信息：
DOI：10.14028/j.cnki.1003-3726.2024.24.108
CLC：Published：20 October 2024，
Published Online：02 July 2024，
Received：10 April 2024，
Accepted：21 May 2024
- 稿件说明：
移动端阅览
张广明, 王保平, 程萍, 范治平, 韩军. 天然高分子抗菌水凝胶伤口敷料研究进展. 高分子通报, 2024, 37(10), 1337–1353
Zhang, G. M.; Wang, B. P.; Cheng, P.; Fan, Z. P.; Han, J. Research progress on natural polymer antibacterial hydrogel wound dressings. Polym. Bull. (in Chinese), 2024, 37(10), 1337–1353
张广明, 王保平, 程萍, 范治平, 韩军. 天然高分子抗菌水凝胶伤口敷料研究进展. 高分子通报, 2024, 37(10), 1337–1353 DOI： 10.14028/j.cnki.1003-3726.2024.24.108.
Zhang, G. M.; Wang, B. P.; Cheng, P.; Fan, Z. P.; Han, J. Research progress on natural polymer antibacterial hydrogel wound dressings. Polym. Bull. (in Chinese), 2024, 37(10), 1337–1353 DOI： 10.14028/j.cnki.1003-3726.2024.24.108.
摘要
天然高分子包括多糖和蛋白质等，其来源广泛且具有丰富的功能基团、易于改性，部分天然高分子还兼具抗菌性能和独特生物学性能，这些特点使其在制备抗菌水凝胶敷料中颇具优势。天然高分子水凝胶通常具有良好的生物相容性、可降解性和亲水性等，其三维结构为抗菌物质提供了理想的负载空间。对于抗菌水凝胶敷料的制备，除了材料的选择，交联策略的设计也至关重要。本文详细汇总了近年来天然高分子抗菌水凝胶敷料的制备方法，包括化学交联、物理交联以及杂化交联等；并且根据抗菌性能的来源，将其分为固有抗菌性能的天然高分子水凝胶和负载抗菌物质的天然高分子水凝胶，进而对这两种水凝胶敷料在医疗、健康等领域的应用进行了详细阐述；最后，对天然高分子抗菌水凝胶现存研究瓶颈进行分析并对其未来发展机遇进行展望。
Abstract
Natural polymers
such as polysaccharides and proteins
are abundant in nature
boasting abundent functional groups that lend themselves readily to modify. Some natural polymers also exhibit inherent antibacterial properties
alongside unique biological attributes. Hydrogels derived from natural polymers typically demonstrate excellent biocompatibility
degradability
and hydrophilicity
owing to their three-dimensional structure which provides an ideal reservoir for antibacterial agents. These attributes confer a distinct advantage upon natural polymers in the formulation of antibacterial hydrogel dressings. Beyond material selection
the choice of crosslinking strategy is pivotal. This work summarizes recent methodologies for the preparation of natural polymer antibacterial hydrogel dressings
encompassing chemical
physical
and hybrid crosslinking techniques. Based on their antibacterial attributes
hydrogels are categorized into two classes: those with inherent antibacterial properties and those laden with antibacterial agents. Detailed accounts are provided regarding the application and potential of these hydrogel dressings in medical
healthcare
and allied domains. Lastly
the extant research bottlenecks are analyzed and the future development for natural polymer antibacterial hydrogels is prospected.
关键词
天然高分子抗菌水凝胶伤口敷料
Keywords
Natural polymerAntibacterial hydrogelWound dressing
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