Research Progress on Biogenic Protein Nano-drug Delivery Systems: Taking Albumin, Silk Fibroin and Zein as Examples

CHEN Qing-xin; LIU Jing-yang; WANG Ya-song; LUO Pei-li; HUANG Zheng-wei

doi:10.14028/j.cnki.1003-3726.2025.24.270

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Research Progress on Biogenic Protein Nano-drug Delivery Systems: Taking Albumin, Silk Fibroin and Zein as Examples

更新时间：2025-02-27

- Research Progress on Biogenic Protein Nano-drug Delivery Systems: Taking Albumin, Silk Fibroin and Zein as Examples
- Polymer Bulletin Vol. 38, Issue 3, Pages: 403-416(2025)
- 作者机构：
  
  暨南大学药学院，广州 511443
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2025.24.270
  CLC：
- Received：16 September 2024，
  
  Accepted：2024-12-09，
  
  Published Online：06 January 2025，
  
  Published：20 March 2025
- 稿件说明：
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陈庆鑫, 刘靖杨, 王亚松, 罗沛力, 黄郑炜. 生物来源蛋白纳米递药系统研究进展: 以白蛋白、丝素蛋白和玉米醇溶蛋白为例. 高分子通报, 2025, 38(3), 403–416.

Chen, Q. X.; Liu, J. Y.; Wang, Y. S.; Luo, P. L.; Huang, Z. W. Research progress on biogenic protein nano-drug delivery systems: taking albumin, silk fibroin and zein as examples. Polym. Bull. (in Chinese), 2025, 38(3), 403–416.
陈庆鑫, 刘靖杨, 王亚松, 罗沛力, 黄郑炜. 生物来源蛋白纳米递药系统研究进展: 以白蛋白、丝素蛋白和玉米醇溶蛋白为例. 高分子通报, 2025, 38(3), 403–416. DOI： 10.14028/j.cnki.1003-3726.2025.24.270.

Chen, Q. X.; Liu, J. Y.; Wang, Y. S.; Luo, P. L.; Huang, Z. W. Research progress on biogenic protein nano-drug delivery systems: taking albumin, silk fibroin and zein as examples. Polym. Bull. (in Chinese), 2025, 38(3), 403–416. DOI： 10.14028/j.cnki.1003-3726.2025.24.270.

摘要

传统给药剂型的药物生物利用度低，且难以实现缓释、定向给药，因此迫切需要开发新的剂型以满足临床需求。纳米递药系统具有可实现靶向给药的特点，引起了人们的广泛关注。其中蛋白质纳米递药系统可显著改善药物的水溶性和稳定性，降低药物的使用剂量以减轻副作用，生物相容性高并且在体内可降解，是一种具有潜在开发价值的生物有机材料。其中，白蛋白纳米粒、丝素蛋白纳米粒、玉米醇溶蛋白纳米粒3种不同生物来源的蛋白纳米粒是极具代表性的蛋白质纳米递药系统。本综述介绍了上述3种蛋白纳米粒的特点、制备方法和应用现状，并讨论了当前研究中存在的难题和可能的解决方案，为进一步开展基于蛋白质纳米粒的新药研发工作提供一定的参考。

Abstract

Drugs in traditional dosage forms have low bioavailability and it is difficult to achieve sustained release and targeted administration. Therefore

it is imperative to develop new dosage forms that meet the clinical needs of patients. Nanocarrier drug delivery systems have the characteristics of achieving targeted drug delivery

which has attracted considerable interest within the scientific community. Among them

the protein nanoparticle delivery system can significantly enhance the water solubility and stability of the drug

reduce the dosage of the drug to alleviate side effects

and be biodegradable in the body with minimal irritation. Among these

albumin nanoparticles

silk fibroin nanoparticles

and zein nanoparticles

three protein nanoparticles derived from different biological sources

are highly representative protein nanoparticle drug delivery systems. This review introduced the characteristics

preparation methods and application status of the aforementioned three protein nanoparticles

and discussed the challenges and possible solutions in the current research

providing a reference for further research and development of new drugs based on protein nanoparticles.

关键词

Keywords

references

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