Hot-press Molding Preparation and Properties of Poly(lactic acid)/Nano-hydroxyapatite Composites

WANG Fei; LONG Xi; HAN Ying-chao

doi:10.14028/j.cnki.1003-3726.2025.25.010

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Hot-press Molding Preparation and Properties of Poly(lactic acid)/Nano-hydroxyapatite Composites

更新时间：2025-07-15

- Hot-press Molding Preparation and Properties of Poly(lactic acid)/Nano-hydroxyapatite Composites
- Polymer Bulletin Vol. 38, Issue 8, Pages: 1280-1290(2025)
- 作者机构：
  
  武汉理工大学，材料复合新技术国家重点实验室，武汉 430070
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2025.25.010
  CLC：
- Received：08 January 2025，
  
  Accepted：12 March 2025，
  
  Published Online：30 April 2025，
  
  Published：20 August 2025
- 稿件说明：
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王飞, 龙玺, 韩颖超. 聚乳酸/纳米羟基磷灰石复合材料热压成型制备及性能研究. 高分子通报, 2025, 38(8), 1280–1290.

Wang, F.; Long, X.; Han, Y. C. Hot-press molding preparation and properties of poly(lactic acid)/nano-hydroxyapatite composites. Polym. Bull. (in Chinese), 2025, 38(8), 1280–1290.
王飞, 龙玺, 韩颖超. 聚乳酸/纳米羟基磷灰石复合材料热压成型制备及性能研究. 高分子通报, 2025, 38(8), 1280–1290. DOI： 10.14028/j.cnki.1003-3726.2025.25.010.

Wang, F.; Long, X.; Han, Y. C. Hot-press molding preparation and properties of poly(lactic acid)/nano-hydroxyapatite composites. Polym. Bull. (in Chinese), 2025, 38(8), 1280–1290. DOI： 10.14028/j.cnki.1003-3726.2025.25.010.

摘要

聚乳酸(PLA)是一种具有良好生物可降解性的骨修复材料，但由于缺乏成骨活性，限制了其在医学上的应用效果，通过与成骨活性成分(如纳米羟基磷灰石(nHAP))复合是改善其生物医学性能的一种有效措施。本研究首先采用乳液溶剂挥发法制备PLA/nHAP复合微球，提高复合均匀性，进而以复合微球为原料经低温热压预成型-热处理工艺制备PLA/nHAP复合材料。结果表明，在130 ℃的热处理温度下，复合微球熔融完全，材料变得致密，且nHAP在PLA中良好分散；随着nHAP的质量分数从0%增加到10%，复合材料的力学性能逐渐增强，压缩强度、弯曲强度分别提高了约14%和42%；水接触角从(70.66±0.64)°减小到(56.49±0.50)°，亲水性增加。PLA/nHAP复合材料可以保持稳定的Ca

、PO

3−

释放。细胞试验结果表明，PLA/nHAP复合材料无细胞毒性，nHAP的复合促进了成骨细胞的黏附与增殖(7天)，且14天后显示出显著地促成骨分化作用。本研究为PLA/nHAP复合材料的制备提供了一种可行的技术方案。

Abstract

Poly(lactic acid) (PLA)

while recognized as a bone repair material due to its commendable biodegradability

faces constraints in medical application effectiveness stemming from its insufficient osteogenic activity. To enhance its biomedical performance

an efficacious approach involves compounding it with osteogenic active components

such as nano-hydroxyapatite (nHAP). This study initially employs the emulsion solvent eva

poration method to fabricate PLA/nHAP composite microspheres

aiming to augment composite homogeneity. Subsequently

these composite microspheres serve as the raw materials for the preparation of PLA/nHAP composites

undergoing a series of processes including hot-press preforming and heat treatment process. The results demonstrate that

at a heat treatment temperature of 130 ℃

the composite microspheres undergo complete melting

leading to a dense material structure with nHAP evenly distributed within the PLA matrix. As the mass fraction of nHAP escalates from 0% to 10%

there is a gradual enhancement in the mechanical properties of the composite material. Specifically

the compression strength

bending strength

and modulus of elasticity exhibit increases of approximately 14% and 42%

respectively. Additionally

the water contact angle diminishes from (70.66±0.64)° to (56.49±0.50)°

signifying an augmentation in hydrophilicity. Furthermore

the PLA/nHAP composite material maintains a steady release of Ca

and PO

3−

. Cellular testing reveals that the PLA/nHAP composite material is non-cytotoxic

and the incorporation of nHAP fosters osteoblast adhesion and proliferation over a 7-day period. After 14 days

significant osteogenic differentiation effects become apparent. In conclusion

this investigation presents a viable technical method for the fabrication of PLA/nHAP composite materials.

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