Visualization of Intermolecular Forces:——Popular Science Outreach on Simulating Protein Aggregation-induced Neurodegenerative Pathologies <italic style="font-style: italic">via</italic> Polyelectrolyte Models

WANG Lu-xue; ZHU Hong-liang; XU Xing-yan; LIU Xiao-li; YAN Hua-ni; SONG Yan-hua; YE Lin; ZHONG Hai-zheng; SHI Jian-bing

doi:10.14028/j.cnki.1003-3726.2025.25.067

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Visualization of Intermolecular Forces:——Popular Science Outreach on Simulating Protein Aggregation-induced Neurodegenerative Pathologies via Polyelectrolyte Models

更新时间：2025-08-26

- Visualization of Intermolecular Forces:——Popular Science Outreach on Simulating Protein Aggregation-induced Neurodegenerative Pathologies via Polyelectrolyte Models
- Polymer Bulletin Vol. 38, Issue 9, Pages: 1425-1432(2025)
- 作者机构：
  
  1.北京理工大学材料学院，北京 100081
  2.北京理工大学教育学院，北京 100081
  3.北京市大兴区兴华中学，北京 102600
  4.北京理工大学附属实验学校，北京 102400
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2025.25.067
  CLC：
- Received：27 March 2025，
  
  Accepted：23 May 2025，
  
  Published Online：14 July 2025，
  
  Published：20 September 2025
- 稿件说明：
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WANG Lu-xue, ZHU Hong-liang, XU Xing-yan, LIU Xiao-li, YAN Hua-ni, SONG Yan-hua, YE Lin, ZHONG Hai-zheng, SHI Jian-bing. Visualization of Intermolecular Forces:——Popular Science Outreach on Simulating Protein Aggregation-induced Neurodegenerative Pathologies via Polyelectrolyte Models[J]. Polymer bulletin, 2025, 38(9): 1425-1432.
DOI：

WANG Lu-xue, ZHU Hong-liang, XU Xing-yan, LIU Xiao-li, YAN Hua-ni, SONG Yan-hua, YE Lin, ZHONG Hai-zheng, SHI Jian-bing. Visualization of Intermolecular Forces:——Popular Science Outreach on Simulating Protein Aggregation-induced Neurodegenerative Pathologies via Polyelectrolyte Models[J]. Polymer bulletin, 2025, 38(9): 1425-1432. DOI： 10.14028/j.cnki.1003-3726.2025.25.067.

摘要

利用高分子电解质阴、阳离子间的强分子间作用力，模拟神经退行性疾病中蛋白质间的不同聚集状态，演示分子间作用力在聚集体形成过程中的调控机制，帮助大、中、小学生群体理解神经退行性疾病的发病原理，激发他们的科学兴趣。相比于使用真实发病过程中的蛋白质，该科普实验使用的高分子电解质具有成本低、易操作等优点，且分子间作用力更强，能够更直观、快速地展示出分子间作用力与发病机制的关系，具有可操作、易普及的特点。此外，该科普实验设计简单、现象明显，利于中小学教师实验准备、课堂演示，更有利于学生动手实践、思维拓展等科学素质的培养。

Abstract

Strong intermolecular force between anionic polyelectrolytes and cationic polyelectrolytes was used to simulate different aggregation states between proteins in neurodegenerative diseases

and the regulatory mechanism of intermolecular force in the formation of aggregates was demonstrated. It aims to help students in primary

middle and high school understand the pathogenesis of neurodegenerative diseases and stimulate their scientific interest. Compared with proteins in the real pathogenesis process

the polyelectrolyte used in this popular science experiment has the advantages of low cost

easy operation

and stronger intermolecular interaction. All these characteristics can display the relationship between intermolecular force and pathogenesis more intuitively and quickly

which has the features of being operable and easy to be popularized. In addition

the design of this popular experiment is simple and the phenomenon is obvious

which is conducive to the experiment preparation and classroom demonstration of primary

middle and high school teachers. moreover

this popularization of science is more beneficial to the cultivation of students’ scientific qualities such as hands-on practice and thinking expansion.

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references

中华人民共和国民政部 [EB/OL ] . 2023年民政事业发展统计公报 https://www.mca.gov.cn/n156/n2679/c1662004999980001204/content.html https://www.mca.gov.cn/n156/n2679/c1662004999980001204/content.html . 2024-08-30 .

苏燕 , 李祯祺 , 周琳颖 , 徐萍 . 神经退行性疾病领域国际研发态势分析 . 科学观察 , 2018 , 13 ( 3 ), 1 – 8 .

Tao, M. J. ; Guo, H. Y. ; Ji, X. C. ; Wang, W. ; Yuan, H. ; Peng, H . Long-term trends in Alzheimer's disease and other dementias deaths with high body mass index in China from 1990 to 2019, and projections up to 2042 . Arch. Public Health , 2024 , 82 ( 1 ), 42 .

Song, S. Y. ; Ivanov, T. ; Yuan, D. D. ; Wang, J. Q. ; da Silva, L. C. ; Xie, J. ; Cao, S. P . Peptide-based biomimetic condensates via liquid-liquid phase separation as biomedical delivery vehicles . Biomacromolecules , 2024 , 25 ( 9 ), 5468 – 5488 .

薛小燕 , 郭小华 , 李敏 , 罗焕敏 . 神经退行性疾病发病机制研究进展 . 中国老年学杂志 , 2015 , 35 ( 11 ), 3149 – 3152 .

Abbas, M. ; Lipiński, W. P. ; Wang, J. H. ; Spruijt, E . Peptide-based coacervates as biomimetic protocells . Chem. Soc. Rev. , 2021 , 50 ( 6 ), 3690 – 3705 .

Mehta, S. ; Zhang, J . Liquid-liquid phase separation drives cellular function and dysfunction in cancer . Nat. Rev. Cancer , 2022 , 22 ( 4 ), 239 – 252 .

Brangwynne, C. P. ; Tompa, P. ; Pappu, R. V . Polymer physics of intracellular phase transitions . Nat. Phys. , 2015 , 11 ( 11 ), 899 – 904 .

Li, P. L. ; Banjade, S. ; Cheng, H. C. ; Kim, S. ; Chen, B. Y. ; Guo, L. ; Llaguno, M. ; Hollingsworth, J. V. ; King, D. S. ; Banani, S. F. ; Russo, P. S. ; Jiang, Q. X. ; Nixon, B. T. ; Rosen, M. K . Phase transitions in the assembly of multivalent signalling proteins . Nature , 2012 , 483 ( 7389 ), 336 – 340 .

Ainani, H. ; Bouchmaa, N. ; Ben Mrid, R. ; El Fatimy, R . Liquid-liquid phase separation of protein tau: an emerging process in Alzheimer's disease pathogenesis . Neurobiol. Dis. , 2023 , 178 , 106011 .

Boija, A. ; Klein, I. A. ; Young, R. A . Biomolecular condensates and cancer . Cancer Cell , 2021 , 39 ( 2 ), 174 – 192 .

Wang, Q. F. ; Schlenoff, J. B . The polyelectrolyte complex/coacervate continuum . Macromolecules , 2014 , 47 ( 9 ), 3108 – 3116 .

Cakmak, F. P. ; Choi, S. ; Meyer, M. O. ; Bevilacqua, P. C. ; Keating, C. D . Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments . Nat. Commun. , 2020 , 11 ( 1 ), 5949 .

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Visualization of Intermolecular Forces:——Popular Science Outreach on Simulating Protein Aggregation-induced Neurodegenerative Pathologies via Polyelectrolyte Models

DOI：10.14028/j.cnki.1003-3726.2025.25.067

摘要

Abstract

关键词

Keywords

references