Research Progress on Tumor Microenvironment-responsive Poly(amino acid)-based Drug Carriers

ZHANG Niu-niu; OUYANG Yi-fan; SHEN Cheng-wan; CHEN Ya-juan; ZHOU Peng-qian; WANG Ji-wei

doi:10.14028/j.cnki.1003-3726.2025.25.102

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Research Progress on Tumor Microenvironment-responsive Poly(amino acid)-based Drug Carriers

更新时间：2025-08-26

- Research Progress on Tumor Microenvironment-responsive Poly(amino acid)-based Drug Carriers
- Polymer Bulletin Vol. 38, Issue 9, Pages: 1345-1363(2025)
- 作者机构：
  
  1.宁德师范学院，闽东畲医药福建省高校工程研究中心，宁德 352100
  2.福州大学化学学院，福州 350100
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2025.25.102
  CLC：
- Received：05 April 2025，
  
  Accepted：23 May 2025，
  
  Published Online：04 August 2025，
  
  Published：20 September 2025
- 稿件说明：
移动端阅览
ZHANG Niu-niu, OUYANG Yi-fan, SHEN Cheng-wan, CHEN Ya-juan, ZHOU Peng-qian, WANG Ji-wei. Research Progress on Tumor Microenvironment-responsive Poly(amino acid)-based Drug Carriers[J]. Polymer bulletin, 2025, 38(9): 1345-1363.
DOI：

ZHANG Niu-niu, OUYANG Yi-fan, SHEN Cheng-wan, CHEN Ya-juan, ZHOU Peng-qian, WANG Ji-wei. Research Progress on Tumor Microenvironment-responsive Poly(amino acid)-based Drug Carriers[J]. Polymer bulletin, 2025, 38(9): 1345-1363. DOI： 10.14028/j.cnki.1003-3726.2025.25.102.

摘要

肿瘤微环境响应型药物载体在肿瘤治疗中具有独特的优势，聚氨基酸分子由于良好的生物相容性、生物降解性、特殊的生物活性以及易于修饰等特点，在响应型药物载体领域得到广泛的关注和应用。本文综述了基于pH值、活性氧(ROS)、谷胱甘肽(GSH)、温度和酶等内源性以及光等外源性的不同刺激响应型聚氨基酸纳米药物载体的设计、制备及其抗肿瘤应用研究。据此对肿瘤微环境响应型聚氨基酸药物载体的未来研究方向进行了展望，以期为聚氨基酸类化合物作为药物载体的研究提供一定思路和借鉴。

Abstract

Tumor microenvironment-responsive drug carriers exhibit unique advantages in cancer therapy. Amino acid molecules have garnered extensive attention and application in the field of responsive drug carriers due to their excellent biocompatibility

biodegradability

distinctive bioactivity

and ease of modification. This review summarizes the design

preparation

and antitumor applications of various stimulus-responsive poly(amino acid)-based nanodrug carriers

including endogenous stimuli (such as pH

reactive oxygen species

glutathione

temperature

and enzymes) and exogenous stimuli (for example light). Based on this

future research directions for tumor microenvironment-responsive poly(amino acid) drug carriers are discussed

aiming to provide insights and references for the development of poly(amino acid)-based drug delivery systems.

关键词

Keywords

references

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