Decoding Supramolecular Hydrogels: From Programmable Mechanics to Biological Effects

LIU Jia-chang; CHEN Ze-kun; ZHANG Kun-yu; BIAN Li-ming

doi:10.14028/j.cnki.1003-3726.2025.25.244

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Decoding Supramolecular Hydrogels: From Programmable Mechanics to Biological Effects

更新时间：2026-01-16

- Decoding Supramolecular Hydrogels: From Programmable Mechanics to Biological Effects
- Polymer Bulletin Vol. 39, Issue 1, Pages: 39-61(2026)
- 作者机构：
  
  华南理工大学生物医学科学与工程学院　广州 511442
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2025.25.244
  CLC：
- Received：28 August 2025，
  
  Accepted：26 September 2025，
  
  Published Online：21 November 2025，
  
  Published：20 January 2026
- 稿件说明：
移动端阅览
刘家畅, 陈泽鲲, 张琨雨, 边黎明. 解码超分子水凝胶：从可编程力学到生物学效应. 高分子通报, 2026, 39(1), 39–61.

Liu, J. C.; Chen, Z. K.; Zhang, K. Y.; Bian, L. M. Decoding supramolecular hydrogels: from programmable mechanics to biological effects. Polym. Bull. (in Chinese), 2026, 39(1), 39–61.
刘家畅, 陈泽鲲, 张琨雨, 边黎明. 解码超分子水凝胶：从可编程力学到生物学效应. 高分子通报, 2026, 39(1), 39–61. DOI： 10.14028/j.cnki.1003-3726.2025.25.244.

Liu, J. C.; Chen, Z. K.; Zhang, K. Y.; Bian, L. M. Decoding supramolecular hydrogels: from programmable mechanics to biological effects. Polym. Bull. (in Chinese), 2026, 39(1), 39–61. DOI： 10.14028/j.cnki.1003-3726.2025.25.244.

摘要

近年来，随着智能化设计、复杂功能集成及先进制造技术的推动，超分子水凝胶逐渐成为高分子与生物医用材料领域的研究热点。该类材料基于主–客体识别、静电作用、离子配位等动态非共价相互作用构建网络，赋予其区别于传统共价交联水凝胶的独特智能特性，在刺激响应性、动态可逆性、自愈合性及剪切稀化等方面表现突出。同时，超分子水凝胶凭借灵活的力学调控机制，可通过调节交联密度、匹配动态键能量及设计网络拓扑结构，实现力学性能与生物功能的高度适配，并在组织工程、药物递送和创面修复等应用中展现出显著优势。本文系统梳理了近年来超分子水凝胶在结构组成与构筑策略等方面的进展，基于超分子水凝胶力学特性可调控的视角，进一步分析其材料生物学效应在临床转化与多尺度力学生物学研究中的挑战与机遇，以期为该领域的持续发展提供参考。

Abstract

In recent years

driven by intelligent design

complex functional integration

and advanced manufacturing technologies

supramolecular hydrogels have become a research hotspot in the field of polymers and biomedical materials. These materials construct networks based on dynamic noncovalent interactions such as host-guest recognition

electrostatic interactions

and ionic coordination

endowing them with unique intelligent properties that distinguish them from traditional covalently cross-linked hydrogels. They exhibit remarkable stimuli-responsiveness

dynamic reversibility

self-healing

and shear-thinning properties. Furthermore

supramolecular hydrogels

through their flexible mechanical regulation mechanisms

can achieve a high degree of adaptation between mechanical properties and biological functions by adjusting cross-linking density

matching dynamic bond energies

and designing network topology. These hydrogels have demonstrated significant advantages in applications such as tissue engineering

drug delivery

and wound repair. This review systematically reviews recent advances in supramolecular hydrogels in terms of structural composition and construction strategies

focusing on their biological effects and application prospects based on the view of controllable mechanical property of supramolecular hydrogels. Furthermore

we analyze the challenges and opportunities in clinical translation and multiscale mechanobiology research

aiming to provide a reference for the continued development of this field.

关键词

Keywords

references

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JIANG Hao

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School of Material Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University

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School of Materials and Energy, Guangdong University of Technology

School of Chemical Engineering and Technology , Tianjin University

Technical Center for Safety of Industrial Products of Tianjin Entry-Exit Inspection and Quarantine Bureau of P. R. China

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