Research Progress on Precipitation Polymerization and Morphology Regulation of Functional Polymer Microspheres

ZHANG Yu-fei; CHANG Tian-xiao; SHI Xing-bo; CAI Yu-dong; CHEN Shang-tao; DU Bin-yang

doi:10.14028/j.cnki.1003-3726.2025.25.272

您当前的位置：

首页 >

文章列表页 >

Research Progress on Precipitation Polymerization and Morphology Regulation of Functional Polymer Microspheres

更新时间：2026-03-02

- Research Progress on Precipitation Polymerization and Morphology Regulation of Functional Polymer Microspheres
- Polymer Bulletin Vol. 39, Issue 3, Pages: 388-404(2026)
- 作者机构：
  
  浙江大学工程师学院　杭州　 310015
  中国石油天然气股份有限公司石油化工研究院　北京　 102206
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2025.25.272
  CLC：
- Received：11 September 2025，
  
  Accepted：27 October 2025，
  
  Online First：17 December 2025，
  
  Published：20 March 2026
- 稿件说明：
移动端阅览
张瑜菲, 常添笑, 石行波, 蔡玉东, 陈商涛, 杜滨阳. 功能性聚合物微球的沉淀聚合制备技术形貌调控研究进展. 高分子通报, 2026, 39(3), 388-404.

Zhang, Y. F.; Chang, T. X.; Shi, X. B.; Cai, Y. D.; Chen, S. T.; Du, B. Y. Research progress on precipitation polymerization and morphology regulation of functional polymer microspheres. Polym. Bull. (in Chinese), 2026, 39(3), 388-404.
张瑜菲, 常添笑, 石行波, 蔡玉东, 陈商涛, 杜滨阳. 功能性聚合物微球的沉淀聚合制备技术形貌调控研究进展. 高分子通报, 2026, 39(3), 388-404. DOI： 10.14028/j.cnki.1003-3726.2025.25.272.

Zhang, Y. F.; Chang, T. X.; Shi, X. B.; Cai, Y. D.; Chen, S. T.; Du, B. Y. Research progress on precipitation polymerization and morphology regulation of functional polymer microspheres. Polym. Bull. (in Chinese), 2026, 39(3), 388-404. DOI： 10.14028/j.cnki.1003-3726.2025.25.272.

摘要

功能性聚合物微球因其独特的微观形貌和优异的性能，在生物医学、化工、电子信息、环境等领域具有广阔的应用前景。沉淀聚合作为制备功能性聚合物微球的核心技术之一，相较于其他制备方法，因其具有产物纯度高、粒径可控且无需外加添加剂等优势而备受关注。本文综述了不同类型沉淀聚合(如传统沉淀聚合、蒸馏/回流沉淀聚合、光引发沉淀聚合、可控/“活性”自由基沉淀聚合、自稳定沉淀聚合)的工艺特点及应用场景，并结合沉淀聚合的三大典型机理，探讨了温度、单体浓度、搅拌速率、溶剂性质、交联剂等关键参数对微球形貌的调控规律，为功能性微球的可控制备与高端化应用提供理论、实验参考以及研究思路。

Abstract

Functional polymer microspheres

known for their well-controlled morphology and unique functions

have broad applications in biomedicine

chemical engineering

electronic information

and environmental protection. Precipitation polymerization is a key technology for preparing functional polymer microspheres and stands out among other conventional methods because of its distinct advantages

such as high product purity

controllable particle size

and the absence of additives. This review summarizes the characteristics and applications of various types of precipitation polymerization (including conventional precipitation polymerization

distillation/reflux precipitation polymerization

controlled/“living” radical precipitation polymerization

and self-stabilized precipitation polymerization) and discusses the influence of key parameters

such as temperature

monomer concentration

stirring rate

solvent

and crosslinking agent

on the morphologies and properties of the resulting microspheres based on the three typical mechanisms of precipitation. This review provides theoretical and experimental references for the controlled preparation of functional microspheres and highlights promising research directions for their high-end applications.

关键词

Keywords

references

Qin, J. X. ; Su, Z. ; Mao, Y. H. ; Liu, C. C. ; Qi, B. ; Fang, G. Z. ; Wang, S . Carboxyl-functionalized hollow polymer microspheres for detection of trace metal elements in complex food matrixes by ICP-MS assisted with solid-phase extraction . Ecotoxicol. Environ. Saf. , 2021 , 208 , 111729 .

Tan, J. B. ; Li, X. L. ; He, J. ; Xu, Q. ; Zhang, Y. X. ; Dai, X. C. ; Yu, L. L. ; Zeng, R. M. ; Zhang, L . Carboxyl-functionalized polymeric microspheres prepared by one-stage photoinitiated RAFT dispersion polymerization . Polymers , 2017 , 9 ( 12 ), 681 .

Oh, J. S. ; Dang, L. N. ; Yoon, S. W. ; Lee, P. C. ; Kim, D. O. ; Kim, K. J. ; Nam, J. D . Amine-functionalized polyglycidyl methacrylate microsphere as a unified template for the synthesis of gold nanoparticles and single-crystal gold plates . Macromol. Rapid Commun. , 2013 , 34 ( 6 ), 504 – 510 .

Tan, J. B. ; Fu, L. L. ; Zhang, X. C. ; Bai, Y. H. ; Zhang, L . Photosynthesis of poly(glycidyl methacrylate) microspheres: a component for making covalently cross-linked colloidosomes and organic/inorganic nanocomposites . J. Mater. Sci. , 2016 , 51 ( 20 ), 9455 – 9471 .

Varyambath, A. ; Kim, M. R. ; Kim, I . Sulfonic acid-functionalized organic knitted porous polyaromatic microspheres as heterogeneous catalysts for biodiesel production . New J. Chem. , 2018 , 42 ( 15 ), 12745 – 12753 .

Ozer, O. ; Ince, A. ; Karagoz, B. ; Bicak, N . Crosslinked PS-DVB microspheres with sulfonated polystyrene brushes as new generation of ion exchange resins . Desalination , 2013 , 309 , 141 – 147 .

Dou, J. B. ; Zhang, Q. Y. ; Ma, M. L. ; Gu, J. W . Fast fabrication of epoxy-functionalized magnetic polymer core-shell microspheres using glycidyl methacrylate as monomer via photo-initiated miniemulsion polymerization . J. Magn. Magn. Mater. , 2012 , 324 ( 19 ), 3078 – 3082 .

Cai, S. Y. ; Weng, Z. L. ; Zheng, Y. C. ; Zhao, B. ; Gao, Z. G. ; Gao, C . High porosity microspheres with functional groups synthesized by thiol-yne click suspension polymerization . Polym. Chem. , 2016 , 7 ( 48 ), 7400 – 7407 .

Ma, Z. Y. ; Guan, Y. P. ; Liu, X. Q. ; Liu, H. Z . Preparation and characterization of micron-sized non-porous magnetic polymer microspheres with immobilized metal affinity ligands by modified suspension polymerization . J. Appl. Polym. Sci. , 2005 , 96 ( 6 ), 2174 – 2180 .

Kartal, F. ; Denizli, A . Surface molecularly imprinted magnetic microspheres for the recognition of albumin . J. Sep. Sci. , 2014 , 37 ( 15 ), 2077 – 2086 .

Zhang, Z. P. ; Eyster, T. W. ; Ma, P. X . Nanostructured injectable cell microcarriers for tissue regeneration . Nanomedicine , 2016 , 11 ( 12 ), 1611 – 1628 .

Jun, Y. J. ; Oh, H. ; Karpoormath, R. ; Jha, A. ; Patel, R . Role of microsphere as drug carrier for osteogenic differentiation . Int. J. Polym. Mater. Polym. Biomater. , 2021 , 70 ( 5 ), 318 – 327 .

Patra, A. ; Satpathy, S. ; Naik, P. K. ; Kazi, M. ; Hussain, M. D . Folate receptor-targeted PLGA-PEG nanoparticles for enhancing the activity of genistein in ovarian cancer . Artif. Cells Nanomed. Biotechnol. , 2022 , 50 ( 1 ), 228 – 239 .

Xu, Y. ; Liu, Y. L. ; Liu, Q. ; Lu, S. Z. ; Chen, X. L. ; Xu, W. R. ; Shi, F . Co-delivery of bufalin and nintedanib via albumin sub-microspheres for synergistic cancer therapy . J. Control. Release , 2021 , 338 , 705 – 718 .

Liu, X. H. ; Jin, X. B. ; Ma, P. X . Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair . Nat. Mater. , 2011 , 10 ( 5 ), 398 – 406 .

Klar, R. M. ; Cox, J. C. ; Houchen, C. J. ; Raja, N. ; Bouloussa, H. ; Lohfeld, S . The induction of bone formation by 3D-printed PLGA microsphere scaffolds in a calvarial orthotopic mouse model: a pilot study . Front. Bioeng. Biotechnol. , 2024 , 12 , 1425469 .

Zhang, M. M. ; Hutchinson, R. A . Design of acrylic dispersants for nonaqueous dispersion polymerization: the importance of thermodynamics . Macromol. React. Eng. , 2018 , 12 ( 5 ), 1800025 .

Borgmann, L. M. ; Johnsen, S. ; Santos de Oliveira, C. ; Martins de Souza E Silva, J. ; Li, J. ; Kirchlechner, C. ; Gomard, G. ; Wiegand, G. ; Hölscher, H . Porous polymeric microparticles foamed with supercritical CO 2 as scattering white pigments . Bioinspir. Biomim. , 2023 , 18 ( 2 ), 026011 .

Zou, J. R. ; Yue, X. G. ; Dong, J. ; Shao, M. L. ; Wang, L. Q. ; Gu, J. ; An, W. J . Novel in-depth profile control agent based on in situ polymeric microspheres in low permeability reservoir . J. Dispers. Sci. Technol. , 2020 , 41 ( 8 ), 1254 – 1264 .

Liu, K. C. ; Wang, R. ; Rong, K. S. ; Yin, Z. B. ; Lu, T. M. ; Yu, Y. S. ; Li, Y. Y. ; Yang, Z. X. ; Yang, J. ; Zhao, Z . Synthesis and plugging performance of nano-micron polymeric gel microsphere plugging agents for oil-based drilling fluids . Gels , 2023 , 9 ( 4 ), 290 .

Fang, Y. C. ; Yan, P. ; Zhang, Q. ; Liu, X. H . Preparation of Janus structural colors with different hydrophilicity by spraying hydrophobic P(HFBMA- co -GMA) micro-spheres on polydopamine modified cotton fabrics . Colloids Surf. A Physicochem. Eng. Aspects , 2024 , 686 , 133386 .

Ma, G. H. ; Fujiwara, J. ; Su, Z. G. ; Omi, S . Synthesis and characterization of crosslinked uniform polymeric microspheres containing a polyimide prepolymer by a new emulsification process . J. Polym. Sci. Part A Polym. Chem. , 2003 , 41 ( 16 ), 2588 – 2598 .

Li, C. M. ; Fan, X. L. ; Zhou, L. W. ; Zhang, B. L. ; Yin, D. Z. ; Zhang, Q. Y . Preparation and assembly performance of colloidal particles of photonic crystals with controlled photonic band gaps . J. Polym. Res. , 2013 , 20 ( 6 ), 153 .

Monier, M. ; Abdel-Latif, D. A. ; Mohammed, H. A . Synthesis and characterization of uranyl ion-imprinted microspheres based on amidoximated modified alginate . Int. J. Biol. Macromol. , 2015 , 75 , 354 – 363 .

Qu, P. ; Li, Y. C. ; Huang, H. Y. ; Wu, G. F. ; Chen, J. J. ; He, F. ; Wang, H. L. ; Gao, B . Foamed urea-formaldehyde microspheres for removal of heavy metals from aqueous solutions . Chemosphere , 2020 , 241 , 125004 .

Li, X. B. ; Li, L. ; Wang, D. H. ; Zhang, J. ; Yi, K. F. ; Su, Y. C. ; Luo, J. ; Deng, X. ; Deng, F . Fabrication of polymeric microspheres for biomedical applications . Mater. Horiz. , 2024 , 11 ( 12 ), 2820 – 2855 .

李乐 , 焦杰 , 周卫 . 不同结构特征的微球制剂在药物递送中的研究进展 . 中国新药杂志 , 2021 , 30 ( 17 ), 1592 – 1599 .

Kim, E. S. ; Lee, M. S. ; Jeong, H. ; Lim, S. Y. ; Kim, D. ; Kim, D. ; Jung, J. ; Lyu, S. Y. ; Cho, H. J. ; Kim, D. M. ; Suh, W. ; Jeong, J. H . Sustained-release microspheres of rivoceranib for the treatment of subfoveal choroidal neovascularization . Pharmaceutics , 2021 , 13 ( 10 ), 1548 .

Lee, E. J. ; Deka, B. J. ; Guo, J. X. ; Woo, Y. C. ; Shon, H. K. ; An, A. K . Engineering the re-entrant hierarchy and surface energy of PDMS-PVDF membrane for membrane distillation using a facile and benign microsphere coating . Environ. Sci. Technol. , 2017 , 51 ( 17 ), 10117 – 10126 .

Debnath, M. K. ; Oyama, W. ; Ono, Y. ; Sugimoto, T. ; Watanabe, R. ; Haraguchi, N . Synthesis of polymer microsphere-supported chiral pyrrolidine catalysts by precipitation polymerization and their application to asymmetric Michael addition reactions . J. Polym. Sci. , 2021 , 59 ( 11 ), 1072 – 1083 .

Pi, C. ; Feng, T. ; Liang, J. ; Liu, H. ; Huang, D. M. ; Zhan, C. L. ; Yuan, J. Y. ; Lee, R. J. ; Zhao, L. ; Wei, Y. M . Polymer blends used to develop felodipine-loaded hollow microspheres for improved oral bioavailability . Int. J. Biol. Macromol. , 2018 , 112 , 1038 – 1047 .

Yang, X. Y. ; Wang, H. ; Zhang, C. ; Ma, Y. H. ; Ma, T. F. ; Zou, W . Preparation of PANI modified hollow microspheres and its application in anti-static buffer foam of OLED under-display . Colloids Surf. A Physicochem. Eng. Aspects , 2024 , 695 , 134235 .

Zhao, T. T. ; Yang, H. ; Xu, X. H. ; Chang, G. T. ; Li, R. X . Modification of hollow expanded microspheres with superior thermal insulation properties and their applications . Chem. , 2023 , 18 ( 6 ), e202201233 .

Kramer, S. ; Stergar, J. ; Ban, I. ; Imperl, J. ; Kolar, M. ; Krajnc, P . Magnetic open porous microspheres via high internal phase emulsion templating as efficient Pb adsorption material . React. Funct. Polym. , 2023 , 192 , 105724 .

Niu, F. F. ; Xu, W. ; Wu, G. ; Lu, S. Y. ; Ou, X. J. ; Chen, Z. B. ; Zhao, X. Y. ; Sun, Y. ; Song, Y. J. ; Zhang, P . Synthesis process and adsorption performance of temperature-sensitive ion-imprinted porous microspheres (ReO 4 − -TIIM) for the selective separation of ReO 4 − . New J. Chem. , 2023 , 47 ( 5 ), 2604 – 2618 .

Li, X. Y. ; Cui, K. P. ; Guo, Z. ; Yang, T. T. ; Cao, Y. ; Xiang, Y. P. ; Chen, H. H. ; Xi, M. F . Heterogeneous Fenton-like degradation of tetracyclines using porous magnetic chitosan microspheres as an efficient catalyst compared with two preparation methods . Chem. Eng. J. , 2020 , 379 , 122324 .

Hoon, C. ; Ho, P. ; Hwan, K. ; Jae, C. ; Park, K. ; Keun, H . Fabrication of core–shell microcapsules using PLGA and alginate for dual growth factor delivery system . J. Control. Release , 2010 , 147 ( 2 ), 193 – 201 .

He, X. ; Liang, C. ; Liu, Q. X. ; Xu, Z. H . Magnetically responsive Janus nanoparticles synthesized using cellulosic materials for enhanced phase separation in oily wastewaters and water-in-crude oil emulsions . Chem. Eng. J. , 2019 , 378 , 122045 .

Wang, L. W. ; Yu, L. ; Zeng, C. F. ; Wang, C. Q. ; Zhang, L. X . Fabrication of PAA–PETPTA Janus microspheres with respiratory function for controlled release of guests with different sizes . Langmuir , 2018 , 34 ( 24 ), 7106 – 7116 .

Zheng, H. H. ; Du, W. ; Duan, Y. Y. ; Geng, K. Y. ; Deng, J. ; Gao, C. Y . Biodegradable anisotropic microparticles for stepwise cell adhesion and preparation of Janus cell microparticles . ACS Appl. Mater. Interfaces , 2018 , 10 ( 43 ), 36776 – 36785 .

Cheng, F. R. ; Su, T. ; Pu, Y. J. ; Gao, W. X. ; He, B . Polymer structure-guided self-assisted preparation of poly(ester-thioether)-based hollow porous microspheres and hierarchically interconnected microcages for drug release . Macromol. Biosci. , 2019 , 19 ( 10 ), 1900171 .

程增会 , 张代晖 , 王基夫 , 王春鹏 , 储富祥 . 单分散聚合物微球的制备及功能化研究进展 . 应用化工 , 2021 , 50 ( 10 ), 2822 – 2828 .

Li, Y. T. ; Zhang, S. F. ; Wang, S. Q. ; He, Z. Y. ; Zhou, Y. L. ; Ren, H . Structure, surface tension, and rheological behaviors of hydrophobically associative polyacrylamides by self-emulsified microemulsion polymerization . J. Appl. Polym. Sci. , 2020 , 137 ( 41 ), 49234 .

Schork, F. J . In support of commercial applications of miniemulsion polymerization . Ind. Eng. Chem. Res. , 2023 , 62 ( 5 ), 2329 – 2335 .

Yang, B. B. ; Xu, L. ; Liu, Y. ; Liu, B. J. ; Zhang, M. Y . Preparation of monodisperse polystyrene microspheres with different functional groups using soap-free emulsion polymerization . Colloid Polym. Sci. , 2021 , 299 ( 7 ), 1095 – 1102 .

Zhang, Y. ; Ding, J. H. ; Gong, S. W . Preparation of molecularly imprinted polymers for vanillin via reversible addition-fragmentation chain transfer suspension polymerization . J. Appl. Polym. Sci. , 2013 , 128 ( 5 ), 2927 – 2932 .

Shestakova, D. O. ; Sankova, N. N. ; Parkhomchuk, E. V . Microsized uniform magnetic polymer microspheres with carboxyl groups . Colloid Polym. Sci. , 2024 , 302 ( 5 ), 695 – 709 .

Macková, H. ; Proks, V. ; Horák, D. ; Kučka, J. ; Trchová, M . Magnetic poly( N -propargylacrylamide) microspheres: preparation by precipitation polymerization and use in model click reactions . J. Polym. Sci. Part A Polym. Chem. , 2011 , 49 ( 22 ), 4820 – 4829 .

Akkoc, E. ; Karagoz, B . One step synthesis of crosslinked fluorescent microspheres for the effective and selective sensing of explosives in aqueous media . Eur. Polym. J. , 2022 , 172 , 111238 .

Fan, M. L. ; Wang, F. ; Wang, C. C . Reflux precipitation polymerization: a new platform for the preparation of uniform polymeric nanogels for biomedical applications . Macromol. Biosci. , 2018 , 18 ( 8 ), 1800077 .

Li, K. ; Stöver, H. D. H . Synthesis of monodisperse poly(divinylbenzene) microspheres . J. Polym. Sci. Part A Polym. Chem. , 1993 , 31 ( 13 ), 3257 – 3263 .

Li, W. H. ; Stöver, H. D. H . Mono- or narrow disperse poly(methacrylate- co -divinylbenzene) microspheres by precipitation polymerization . J. Polym. Sci. Part A Polym. Chem. , 1999 , 37 ( 15 ), 2899 – 2907 .

Bai, F. ; Yang, X. L. ; Huang, W. Q . Synthesis of narrow or monodisperse poly(divinylbenzene) microspheres by distillation–precipitation polymerization . Macromolecules , 2004 , 37 ( 26 ), 9746 – 9752 .

Bai, F. ; Huang, B. ; Yang, X. L. ; Huang, W. Q . Synthesis of monodisperse poly(methacrylic acid) microspheres by distillation–precipitation polymerization . Eur. Polym. J. , 2007 , 43 ( 9 ), 3923 – 3932 .

Zhang, D. W. ; Liu, J. W. ; Liu, T. W. ; Yang, X. L . Synthesis of superhydrophobic fluorinated polystyrene microspheres via distillation precipitation polymerization . Colloid Polym. Sci. , 2015 , 293 ( 6 ), 1799 – 1807 .

Li, Y. G. ; Liu, J. ; Zhang, Y. ; Gu, M. ; Wang, D. Y. ; Dang, Y. Y. ; Ye, B. C. ; Li, Y. C . A robust electrochemical sensing platform using carbon paste electrode modified with molecularly imprinted microsphere and its application on methyl parathion detection . Biosens. Bioelectron. , 2018 , 106 , 71 – 77 .

Wang, F. ; Zhang, Y. T. ; Yang, P. ; Jin, S. ; Yu, M. ; Guo, J. ; Wang, C. C . Fabrication of polymeric microgels using reflux-precipitation polymerization and its application for phosphoprotein enrichment . J. Mater. Chem. B , 2014 , 2 ( 17 ), 2575 – 2582 .

Xu, K. J. ; Zhao, X. Y. ; Yu, J. F. ; Nong, Q. Y. ; Qian, H . Preparation of poly(acrylonitrile-co-styrene) microspheres by reflux precipitation polymerization . J. Macromol. Sci. Part A , 2024 , 61 ( 10 ), 742 – 751 .

Jin, S. ; Li, D. ; Yang, P. ; Guo, J. ; Lu, J. Q. ; Wang, C. C . Redox/pH stimuli-responsive biodegradable PEGylated P(MAA/BACy) nanohydrogels for controlled releasing of anticancer drugs . Colloids Surf. A Physicochem. Eng. Aspects , 2015 , 484 , 47 – 55 .

Limé, F. ; Irgum, K . Monodisperse polymeric particles by photoinitiated precipitation polymerization . Macromolecules , 2007 , 40 ( 6 ), 1962 – 1968 .

Limé, F. ; Irgum, K . Preparation of divinylbenzene and divinylbenzene- co -glycidyl methacrylate particles by photoinitiated precipitation pol ymerization in different solvent mixtures . Macromolecules , 2009 , 42 ( 13 ), 4436 – 4442 .

Gu, X. L. ; Sun, H. W. ; Kong, X. Z. ; Fu, C. H. ; Yu, H. ; Li, J. ; Wang, J. H . A green protocol to prepare monodisperse poly(TMPTMA-styrene) microspheres by photoinitiated precipitation polymerization in low-toxicity solvent . Colloid Polym. Sci. , 2013 , 291 ( 7 ), 1771 – 1779 .

Zhang, H. Q . Controlled/“living” radical precipitation polymerization: a versatile polymerization technique for advanced functional polymers . Eur. Polym. J. , 2013 , 49 ( 3 ), 579 – 600 .

Jiang, J. S. ; Zhang, Y. ; Guo, X. Z. ; Zhang, H. Q . Narrow or monodisperse, highly cross-linked, and “living” polymer microspheres by atom transfer radical precipitation polymerization . Macromolecules , 2011 , 44 ( 15 ), 5893 – 5904 .

Li, Y. T. ; Qian, X. P. ; Tan, X. L. ; Liu, X. H. ; Li, Y. ; Ming, D. M. ; Zhang, L. H. ; Yang, Y. Q . Hydrophilic polymer-brush functional fluorescent nanoparticles to suppress nonspecific interactions and enhance quantum yield for targeted cell imaging . ACS Appl. Polym. Mater. , 2020 , 2 ( 6 ), 2238 – 2245 .

Zhao, M. ; Zhang, H. T. ; Ma, F. N. ; Zhang, Y. ; Guo, X. Z. ; Zhang, H. Q . Efficient synthesis of monodisperse, highly crosslinked, and “living” functional polymer microspheres by the ambient temperature iniferter-induced “living” radical precipitation polymerization . J. Polym. Sci. Part A Polym. Chem. , 2013 , 51 ( 9 ), 1983 – 1998 .

Liu, Z. J. ; Chen, D. ; Zhang, J. F. ; Liao, H. D. ; Chen, Y. Z. ; Sun, Y. F. ; Deng, J. Y. ; Yang, W. T . Self-stabilized precipitation polymerization and its application . Research , 2018 , 2018 , 9370490 .

Xing, C. M. ; Yang, W. T . A novel, facile method for the preparation of uniform, reactive maleic anhydride/vinyl acetate copolymer micro- and nanospheres . Macromol. Rapid Commun. , 2004 , 25 ( 17 ), 1568 – 1574 .

陈冬 , 马育红 , 赵长稳 , 王力 , 张先宏 , 杨万泰 . 自稳定沉淀聚合原理、方法及应用 . 中国科学: 化学 , 2020 , 50 ( 7 ), 732 – 742 .

Downey, J. S. ; Frank, R. S. ; Li, W. H. ; Stöver, H. D. H . Growth mechanism of poly(divinylbenzene) microspheres in precipitation polymerization . Macromolecules , 1999 , 32 ( 9 ), 2838 – 2844 .

Yan, Q. ; Zhao, T. Y. ; Bai, Y. W. ; Zhang, F. ; Yang, W. T . Precipitation polymerization in acetic acid: Study of the solvent effect on the morphology of poly(divinylbenzene) . J. Phys. Chem. B , 2009 , 113 ( 10 ), 3008 – 3014 .

Zheng, C. G. ; Zhou, Y. ; Jiao, Y. P. ; Zhang, H. Q . Narrow or monodisperse, physically cross-linked, and “living” spherical polymer particles by one-stage RAFT precipitation polymerization . Macromolecules , 2019 , 52 ( 1 ), 143 – 156 .

Ni, H. M. ; Kawaguchi, H . Mechanism of preparing monodisperse poly(acrylamide/methacrylic acid) microspheres in ethanol. I . J. Polym. Sci. Part A Polym. Chem. , 2004 , 42 ( 11 ), 2823 – 2832 .

Ni, H. M. ; Zhang, H. ; Chen, G. X. ; Liu, J. X. ; Yang, Y. D. ; Zhang, L. J. ; Wu, M. ; Zhan, K. ; Chen, Y. L . Partition of initiators in quasi-static precipitation polymerization of AAm/MAc . Chinese J. Polym. Sci. , 2014 , 32 ( 10 ), 1400 – 1412 .

Ni, H. M. ; Kawaguchi, H . Mechanism of preparing monodispersed poly(acrylamide/methacrylic acid) microspheres in ethanol. II . J. Polym. Sci. Part A Polym. Chem. , 2004 , 42 ( 11 ), 2833 – 2844 .

Wang, G. ; Zhou, L. Y. ; Zhang, P. F. ; Zhao, E. G. ; Zhou, L. H. ; Chen, D. ; Sun, J. M. ; Gu, X. G. ; Yang, W. T. ; Tang, B. Z . Fluorescence self-reporting precipitation polymerization based on aggregation-induced emission for constructing optical nanoagents . Angew. Chem. Int. Ed. , 2020 , 59 ( 25 ), 10122 – 10128 .

Xu, J. J. ; Han, H. ; Zhang, L. ; Zhu, X. L. ; Jiang, X. B. ; Kong, X. Z . Preparation of highly uniform and crosslinked polyurea microspheres through precipitation copolymerization and their property and structure characterization . RSC Adv. , 2014 , 4 ( 61 ), 32134 – 32141 .

Chang, T. X. ; Qi, H. Y. ; Liang, C. X. ; Huang, Y. B. ; Yang, W. T . A facile approach for the preparation of poly(benzothiophene- alt -maleic anhydride) microspheres by self-stabilized precipitation polymerization . Polym. Chem. , 2022 , 13 ( 27 ), 4054 – 4063 .

张洁 , 刘振杰 , 张晓尘 , 张嘉桐 , 代增悦 . 单分散马来酸酐/己烯交联共聚物微球的制备 . 石油化工 , 2023 , 52 ( 11 ), 1530 – 1536 .

贺杰 , 岳湘安 , 孙雨 , 谭鑫 . 乙醇中沉淀聚合合成聚(AAm-DVB)微球 . 高分子通报 , 2015 ,( 6 ), 44 – 49 .

Yang, S. ; Shim, S. E. ; Lee, H. ; Kim, G. P. ; Choe, S . Size and uniformity variation of poly(MMA- co -DVB) particles upon precipitation polymerization . Macromol. Res. , 2004 , 12 ( 5 ), 519 – 527 .

Yuan, Y. B. ; Yong, X. Y. ; Zhang, H. Y. ; Deng, J. P . Biobased microspheres consisting of poly(trans-anethole- co -maleic anhydride) prepared by precipitation polymerization and adsorption performance . ACS Sustainable Chem. Eng. , 2016 , 4 ( 3 ), 1446 – 1453 .

Views

649

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Preparation and Properties of Antibacterial Polymer Structural Color Microspheres

Preparation of Lignin-based Polymer Microspheres and Study on Solar Photothermal Conversion Properties

Development Status and Prospect of Domestic Integrated Rubber SIBR

Preparation of Poly (AAm-DVB) Microspheres by Precipitation Polymerization in Ethanol

Related Author

CHEN Shang-tao

CAI Yu-dong

SHI Xing-bo

CHANG Tian-xiao

ZHANG Yu-fei

FANG Yin-chun

TAO Wei-han

GU Zi-long

Related Institution

Petrochemical Research Institute, PetroChina Co Ltd.

School of Textile and Garment, Anhui Polytechnic University

School of Environmental and Natural Resources, Zhejiang University of Science and Technology

School of Biological & Chemical Engineering, Zhejiang University of Science and Technology

Hangzhou Seemore New Material Technology Co., Ltd.

⁰