

浏览全部资源
扫码关注微信
中石化(北京)化工研究院有限公司 北京 100013
Received:27 January 2026,
Accepted:02 April 2026,
移动端阅览
王霞. 基于甲基乙烯基醚–马来酸酐共聚物的应用研究进展. 高分子通报, doi: 10.14028/j.cnki.1003-3726.2026.26.045
Wang, X. Research progress on application of poly(methyl vinyl ether-alt-maleic anhydride). Polym. Bull. (in Chinese), doi: 10.14028/j.cnki.1003-3726.2026.26.045
甲基乙烯基醚−马来酸酐共聚物(PMVEMA)作为一种水溶性高分子聚合物,表现出典型的电解质聚合物特性,且具有灵活的结构修饰性、良好的黏附性和生物相容性等优点,因此,其在高附加值领域的研究中已被广泛利用。本文介绍了PMVEMA的结构与性能关系、工业化合成方法及当前面临的问题,并着重从PMVEMA的结构修饰与功能化作用出发,系统综述了其近年来在电池、环保和生物医用领域中的研究进展,具体包括锂离子电池、钙钛矿太阳能电池、废水处理、农药降解、生物成像、药物载体、皮肤贴片及抗菌材料。在此基础上,结合不同领域,进一步分析了PMVEMA产业化面临的关键挑战,并探讨了未来发展方向与策略,以期为PMVEMA的产业化研究与应用提供参考和启示。
Poly(methyl vinyl ether-
alt
-maleic anhydride) (PMVEMA)
a water-soluble polymer
exhibits the typical characteristics of electrolyte polymers and offers advantages such as an easily modifiable structure
excellent adhesive properties
and biocompatibility. Therefore
PMVEMA has been widely utilized in studies of high value-added fields. This article introduces the structure-property relationships
industrial synthesis methods
and current problems associated with PMVEMA. Moreover
focusing on the structural modification and functional role of PMVEMA
this review systematically reviewed its research progress in the fields of batteries
environmental protection
and biomedical applications in recent years
including lithium-ion batteries
perovskite solar cells
wastewater treatment
pesticide degradation
bioimaging
drug delivery
skin patches
and antibacterial materials. On this basis
combined with various fields
this review further explores the current challenges and future development directions of PMVEMA in industrial applications. We hope that this review can provide a reference and inspiration for the industrialization study and application of PMVEMA.
Andrews, G. P. ; Laverty, T. ; Jones, D. S . Mucoadhesive polymeric polyologels designed for the treatment of periodontal and related diseases of the oral cavity . Polymers , 2024 , 16 ( 5 ), 589 .
Jones, D. S. ; Laverty, T. P. ; Morris, C. ; Andrews, G. P . Statistical modelling of the rheological and mucoadhesive properties of aqueous poly(methyl-vinylether- co -maleic acid) networks: redefining biomedical application s and the relationship between viscoelasticity and mucoadhesion . Colloids Surf. B Biointerfaces , 2016 , 144 , 125 – 134 .
Smart, J. D . Recent developments in the use of bioadhesive systems for delivery of drugs to the oral cavity . Crit. Rev. Ther. Drug Carrier Syst , 2004 , 21 ( 4 ), 319 – 344 .
Xu, J. F. ; Genzer, J. ; Efimenko, K . Phosphate recovery and selective desorption with a PEI/PMVEMA hydrogel in a column study . ACS Appl. Eng. Mater. , 2026 , 4 ( 1 ), 225 – 233 .
Corrêa, T. O. ; Tavares, W. S. ; Sousa, F. F. O . Ellagic acid -loaded poly-methyl vinyl ether- co -maleic anhydride (Gantrez®) - gelatin sponges for wound bandaging: preparation, characterization and ex-vivo antibiofilm activity . J. Drug Deliv. Sci. Technol , 2024 , 102 , 106403 .
Pawlaczyk, M. ; Schroeder, G . Dual-polymeric resin based on poly(methyl vinyl ether- alt -maleic anhydride) and pamam dendrimer as a versatile supramolecular adsorbent . ACS Appl. Polym. Mater. , 2021 , 3 ( 2 ), 956 – 967 .
Mira, A. ; Mateo, C. R. ; Mallavia, R. ; Falco, A . Poly(methyl vinyl ether- alt -maleic acid) and ethyl monoester as building polymers for drug-loadable electrospun nanofibers . Sci. Rep. , 2017 , 7 , 17205 .
Badía-Hernández, P. V. ; Carrió, J. M. ; Fuentes-Baile, M. ; Losada-Echeberría, M. ; Díaz-Puertas, R. ; Mira, A. ; Saceda, M. ; García-Morales, P. ; Mallavia, R . Electrospun PMVEMA nanofibers developed as a fast-release platform for antineoplastic drugs tested in glioblastoma primary cultures . Pharmaceutics , 2025 , 17 ( 9 ), 1172 .
Zhu, Y. ; Geng, B. ; Xu, A. H. ; Zhang, L. Q. ; Zhang, S. X . An alternating copolymer of maleic anhydride and ethyl vinyl ether: synthesis in supercritical carbon dioxide, characterization, and properties . Des. Monomers Polym. , 2013 , 16 ( 3 ), 283 – 290 .
Xia, S. X. ; Wu, X. S. ; Zhang, Z. C. ; Cui, Y. ; Liu, W . Practical challenges and future perspectives of all-solid-state lithium-metal batteries . Chem , 2019 , 5 ( 4 ), 753 – 785 .
Tang, B. ; Zhou, Q. ; Du, X. F. ; Zhang, J. J. ; Zhang, H. R. ; Zou, Z. Y. ; Zhou, X. H. ; Cui, G. L . Poly(maleic anhydride) copolymers-based polymer electrolytes enlighten highly safe and high-energy-density lithium metal batteries: advances and prospects . Nano Sel. , 2020 , 1 ( 1 ), 59 – 78 .
Yang, J. F. ; Zhang, M. ; Chen, Z. ; Du, X. F. ; Huang, S. Q. ; Tang, B. ; Dong, T. T. ; Wu, H. ; Yu, Z. ; Zhang, J. J. ; Cui, G. L . Flame-retardant quasi-solid polymer electrolyte enabling sodium metal batteries with highly safe characteristic and superior cycling stability . Nano Res. , 2019 , 12 ( 9 ), 2230 – 2237 .
Valvo, M. ; Liivat, A. ; Eriksson, H. ; Tai, C. W. ; Edström, K . Iron-based electrodes meet water-based preparation, fluorine-free electrolyte and binder: a chance for more sustainable lithium-ion batteries . ChemSusChem , 2017 , 10 ( 11 ), 2431 – 2448 .
Dong, T. T. ; Zhang, J. J. ; Xu, G. J. ; Chai, J. C. ; Du, H. P. ; Wang, L. L. ; Wen, H. J. ; Zang, X. ; Du, A. B. ; Jia, Q. M. ; Zhou, X. H. ; Cui, G. L . A multifunctional polymer electrolyte enables ultra-long cycle-life in a high-voltage lithium metal battery . Energy Environ. Sci. , 2018 , 11 ( 5 ), 1197 – 1203 .
Li, H. ; Du, Y. F. ; Wu, X. M. ; Xie, J. Y. ; Lian, F . Developing “polymer-in-salt” high voltage electrolyte based on composite lithium salts for solid-state Li metal batteries . Adv. Funct. Mater. , 2021 , 31 ( 41 ), 2170307 .
Chen, H. ; Ling, M. ; Hencz, L. ; Ling, H. Y. ; Li, G. R. ; Lin, Z. ; Liu, G. ; Zhang, S. Q . Exploring chemical, mechanical, and electrical functionalities of binders for advanced energy-storage devices . Chem. Rev. , 2018 , 118 ( 18 ), 8936 – 8982 .
Gu, X. X. ; Yang, Z. G. ; Qiao, S. ; Shao, C. B. ; Ren, X. L. ; Yang, J. J . Exploiting methylated amino resin as a multifunctional binder for high-performance lithium–sulfur batteries . Rare Met. , 2021 , 40 ( 3 ), 529 – 536 .
Zhao, Y. ; Liang, Z. ; Kang, Y. Q. ; Zhou, Y. N. ; Li, Y. X. ; He, X. M. ; Wang, L. ; Mai, W. C. ; Wang, X. S. ; Zhou, G. M. ; Wang, J. X. ; Li, J. G. ; Tavajohi, N. ; Li, B. H . Rational design of functional binder systems for high-energy lithium-based rechargeable batteries . Energy Storage Mater. , 2021 , 35 , 353 – 377 .
Chen, H. ; Wu, Z. Z. ; Su, Z. ; Hencz, L. ; Chen, S. ; Yan, C. ; Zhang, S. Q . A hydrophilic poly(methyl vinyl ether- alt -maleic acid) polymer as a green, universal, and dual-functional binder for high-performance silicon anode and sulfur cathode . J. Energy Chem. , 2021 , 62 , 127 – 135 .
Chen, B. ; Rudd, P. N. ; Yang, S. ; Yuan, Y. B. ; Huang, J. S . Imperfections and their passivation in halide perovskite solar cells . Chem. Soc. Rev. , 2019 , 48 ( 14 ), 3842 – 3867 .
Li, B. ; Zhang, Q. Q. ; Zhang, S. ; Chase, Z. ; Chidanguro, T. ; Hunter Davis, A. ; Simon, Y. C. ; Gu, X. D. ; Zheng, W. W. ; Pradhan, N. ; Dai, Q. L . Spontaneously supersaturated nucleation strategy for high reproducible and efficient perovskite solar cells . Chem. Eng. J. , 2021 , 405 , 126998 .
Cao, F. R. ; Wang, M. ; Li, L . Pushing the certified efficiency of inverted perovskite solar cells beyond 24%: a review . Rev. Mater. Res. , 2025 , 1 ( 2 ), 100020 .
Sun, J. ; Chen, L. ; Liu, Z. P. ; Gu, Z. W. ; Song, L. X. ; Du, P. F . Carbonyl-functionalized polymer for synergistic regulation of perovskite crystal quality and interface stability . ACS Appl. Polym. Mater. , 2025 , 7 ( 14 ), 9276 – 9285 .
Wang, Z. L. ; Feng, G. Y. ; Yan, Z. G. ; Li, S. P. ; Xu, M. ; Wang, C. W. ; Li, Y. B . Improving the hydrophilicity and antifouling performance of PVDF membranes via PEI amination and further poly(methyl vinyl ether- alt -maleic anhydride) modification . React. Funct. Polym. , 2023 , 189 , 105610 .
Xu, J. F. ; Efimenko, K. ; Gorman, C. B. ; Yingling, Y. G. ; Castellano, L. ; Genzer, J . Functional hydrogels for selective phosphate removal from water and release on demand . Langmuir , 2025 , 41 ( 23 ), 14753 – 14764 .
George, J. ; Rajagopalan, V. ; Kumar, P. S. ; Purushothaman, M. ; Perumal, P. ; Vaidyanathan, V. K. ; Rangasamy, G . Fabrication and characterization of poly(methyl vinyl ether maleic anhydride) blended poly(lactic acid) ultrafiltration membrane with upgraded antifouling and separation performance . Process. Saf. Environ. Prot. , 2024 , 191 , 2237 – 2246 .
Chen, Y . Organophosphate-induced brain damage: mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies . NeuroToxicology , 2012 , 33 ( 3 ), 391 – 400 .
Zboray, S. ; Efimenko, K. ; Jones, J. L. ; Genzer, J . Functional gels containing hydroxamic acid degrade organophosphates in aqueous solutions . Ind. Eng. Chem. Res. , 2021 , 60 ( 24 ), 8799 – 8811 .
Shapoval, O. ; Ježek, P. ; Horák, D . Liraglutide-conjugated poly(methyl vinyl ether- alt -maleic acid)-coated core–shell upconversion nanoparticles for theranostics of diabetes . ACS Appl. Mater. Interfaces , 2025 , 17 ( 30 ), 42863 – 42876 .
He, M. Y. ; Liu, R. ; Li, X. L. ; Zhang, G. ; Lao, G. X. ; Guo, S. ; Liu, Y. L . Nonconventional luminogens based on poly(methyl vinyl ether maleic anhydride) and 4-(2-aminoethyl)morpholine for Mg 2+ detection and targeting lysosomes . ACS Appl. Polym. Mater. , 2024 , 6 ( 23 ), 14895 – 14904 .
Uglea, C. V. ; Panaitescu, L. ; Spridon, D. ; Ursu, D. ; Popa, I. ; Ottenbrite, R. M . Biological activity of maleic anhydride copolymers I. Biocompatibility and antitumoural effects of maleic anhydride - vinyl acetate, maleic anhydride-methyl methacrylate and maleic anhydride- styrene copolymers . J. Biomater. Sci. Polym. Ed. , 1997 , 8 ( 4 ), 269 – 280 .
Arbós, P. ; Arangoa, M. A. ; Campanero, M. A. ; Irache, J. M . Quantification of the bioadhesive properties of protein-coated PVM/MA nanoparticles . Int. J. Pharm. , 2002 , 242 ( 1-2 ), 129 – 136 .
Henry, S. M. ; El-Sayed, M. E. H. ; Pirie, C. M. ; Hoffman, A. S. ; Stayton, P. S . pH-responsive poly(styrene- alt -maleic anhydride) alkylamide copolymers for intracellular drug delivery . Biomacromolecules , 2006 , 7 ( 8 ), 2407 – 2414 .
Rahmani, A. ; Salmanipour, S. ; Nami, Y. ; Mousavi, H. Z. ; Salehi, R . pH-responsive star-shaped poly- (ε-carprolactone)- co -poly maleic anhydride micelles for synergistic breast cancer combination chemotherapy . React. Funct. Polym. , 2023 , 193 , 105773 .
Kataoka, M. ; Nakanishi, R. ; Umesaki, M. ; Kobayashi, M. ; Minami, K. ; Higashino, H. ; Yamaguchi, S. ; Yamashita, S . An enteric polymer mitigates the effects of gastric pH on oral absorption of poorly soluble weak acid drugs from supersaturable formulations: a case study with dantrolene . Eur. J. Pharm. Biopharm. , 2020 , 155 , 29 – 36 .
Zhao, C. K. ; Yang, J. L. ; Chen, M. F. ; Chen, W. J. ; Yang, X. Y. ; Ye, H. ; Wang, L. Y. ; Wang, Y. ; Shi, J. J. ; Yue, F. X. ; Ma, X . Synthetic lignin-derived therapeutic nano reagent as intestinal pH-sensitive drug carriers capable of bypassing the gastric acid environment for colitis treatment . ACS Nano , 2023 , 17 ( 1 ), 811 – 824 .
Shapoval, O. ; Větvička, D. ; Patsula, V. ; Engstová, H. ; Kočková, O. ; Konefał, M. ; Kabešová, M. ; Horák, D . Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy: studies with pancreatic adenocarcinoma cells in vitro and in vivo . Pharmaceutics , 2023 , 15 ( 12 ), 2694 .
Cakiral, K. ; Sakar, D . Modification of poly(methyl vinyl ether - alt - maleic anhydride) with pregabalin drug active substance via ring opening polymerization of anhydride ring in/noncatalyst media . Polym. Bull. , 2023 , 80 ( 7 ), 7687 – 7714 .
Rubio-Camacho, M. ; Martínez-Tomé, M. J. ; Mira, A. ; Mallavia, R. ; Mateo, C. R . Formation of multicolor nanogels based on cationic polyfluorenes and poly(methyl vinyl ether- alt -maleic monoethyl ester): potential use as pH-responsive fluorescent drug carriers . Int. J. Mol. Sci. , 2021 , 22 ( 17 ), 9607 .
Ren, T. Y. ; Zheng, X. H. ; Bai, R. X. ; Yang, Y. H. ; Jian, L. Y . Bioadhesive poly(methyl vinyl ether- co -maleic anhydride)-TPGS copolymer modified PLGA/lipid hybrid nanoparticles for improving intestinal absorption of cabazitaxel . Int. J. Pharm. , 2022 , 611 , 121301 .
Guo, J. H. ; Luo, Z. Q. ; Wang, F. Y. ; Gu, H. C. ; Li, M. L . Responsive hydrogel microfibers for biomedical engineering . Smart Med. , 2022 , 1 ( 1 ), e20220003 .
Fang, Z. Z. ; Chen, P. ; Ji, Q. ; Yan, C. ; Gong, A. H . Stimuli-responsive hydrogel for disease therapy . Polym. Bull. , 2024 , 81 ( 3 ), 1981 – 2000 .
Tian, B. R. ; Liu, J. Y . Smart stimuli-responsive chitosan hydrogel for drug delivery: a review . Int. J. Biol. Macromol. , 2023 , 235 , 123902 .
Chatterjee, S. ; Hui, P. C . Review of applications and future prospects of stimuli-responsive hydrogel based on thermo-responsive biopolymers in drug delivery systems . Polymers , 2021 , 13 ( 13 ), 2086 .
Pastor, Y. ; Ting, I. ; Martínez, A. L. ; Irache, J. M. ; Gamazo, C . Intranasal delivery system of bacterial antigen using thermosensitive hydrogels based on a Pluronic-Gantrez conjugate . Int. J. Pharm. , 2020 , 579 , 119154 .
García-Verdugo, K. F. ; Ramírez-Irigoyen, A. J. ; Castillo-Ortega, M. ; Rodríguez-Félix, D. E. ; Quiroz-Castillo, J. M. ; Tánori-Córdova, J. ; Rodríguez-Félix, F. ; Ledezma-Pérez, A. ; del Castillo-Castro, T . A pH/temperature-sensitive s-ipn based on poly(vinyl alcohol), poly(vinyl methyl ether- alt -maleic acid) and poly(vinyl methyl ether) prepared by autoclaving . Macromol. Res. , 2022 , 30 ( 6 ), 353 – 364 .
Hu, X. Q. ; Wang, C. ; Huang, J. ; Yan, Y. H. ; Liao, X. Q. ; Li, Y. ; Li, L . Self-adhesive epidermal bioelectrodes for long-term electrophysiological monitoring and emotion recognition . Adv. Mater. Technol. , 2025 , 10 ( 10 ), 2401800 .
Saepang, K. ; Li, S. K. ; Chantasart, D . Passive and iontophoretic transport of pramipexole dihydrochloride across human skin microchannels created by microneedles in vitro . Int. J. Pharm. , 2021 , 609 , 121092 .
Hu, X. Q. ; Liu, C. D. ; Wang, C. ; Han, L. ; Wu, Q. C. ; Wang, Q. ; Cheng, J. ; Li, Y. ; Li, L . Hybrid ion-electron conducting electrodes for long-term electrophysiological monitoring and sign language detection . Chem. Eng. J. , 2025 , 522 , 167812 .
Arunprasert, K. ; Pornpitchanarong, C. ; Rojanarata, T. ; Ngawhirunpat, T. ; Opanasopit, P. ; Aumklad, P. ; Patrojanasophon, P . Development and evaluation of novel water-based drug-in-adhesive patches for the transdermal delivery of ketoprofen . Pharmaceutics , 2021 , 13 ( 6 ), 789 .
Liu, Y. ; Chen, S. B. ; Shi, L. C. ; Yang, S. J. ; Zhang, J. R. ; Liu, C. Q. ; Cheng, J. H. ; Shi, J. J. ; Shen, C. X. ; Gu, D. F. ; Jiang, X. Y . Water-enhanced adhesive interface for high-quality physiological signal monitoring in skin-device integration . Adv. Funct. Mater. , 2026 , 36 ( 12 ), e16396 .
Larrañeta, E. ; Barturen, L. ; Ervine, M. ; Donnelly, R. F . Hydrogels based on poly(methyl vinyl ether- co -maleic acid) and Tween 85 for sustained delivery of hydrophobic drugs . Int. J. Pharm. , 2018 , 538 ( 1-2 ), 147 – 158 .
Larrañeta, E. ; Domínguez-Robles, J. ; Coogan, M. ; Heaney, E. ; Stewart, S. A. ; Thakur, R. R. S. ; Donnelly, R. F . Poly(methyl vinyl ether- co -maleic acid) hydrogels containing cyclodextrins and Tween 85 for potential application as hydrophobic drug delivery systems . Macromol. Res. , 2019 , 27 ( 4 ), 396 – 403 .
Caló, E. ; de Barros, J. M. S. ; Fernández-Gutiérrez, M. ; San Román, J. ; Ballamy, L. ; Khutoryanskiy, V. V . Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether- alt -maleic anhydride) mixtures for wound care applications . RSC Adv. , 2016 , 6 ( 60 ), 55211 – 55219 .
Gao, Y. F. ; Peng, X. W. ; Wu, Q. Q. ; Yang, D. L. ; Wang, W. D. ; Peng, Q. Y. ; Wang, T. ; Wang, J. M. ; Liu, J. F. ; Zhang, H. ; Zeng, H. B . Hydrogen-bonding-driven multifunctional polymer hydrogel networks based on tannic acid . ACS Appl. Polym. Mater. , 2022 , 4 ( 3 ), 1836 – 1845 .
0
Views
0
下载量
0
CSCD
Publicity Resources
Related Articles
Related Author
Related Institution
京公网安备11010802046898号