Research on the Methods for Determination of Molecular Weight of Poly(glycolic acid)

Jun-kai TIAN; Ai-jun CUI; Wei-liang LU; Ye ZHU; Qun CHEN; Ming-yang HE; Gui-bao WU; Ze-yun WANG

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Research on the Methods for Determination of Molecular Weight of Poly(glycolic acid)

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- Research on the Methods for Determination of Molecular Weight of Poly(glycolic acid)
- Polymer Bulletin Vol. 25, Issue 8, Pages: 98-104(2012)
- 作者机构：
  
  1.常州大学江苏省精细石油化工重点实验室，常州　213164
  2.南阳师范学院化学与制药工程学院，南阳　463000
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012-08，
  
  Received：13 February 2012，
  
  Revised：26 March 2012，
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Jun-kai TIAN, Ai-jun CUI, Wei-liang LU, Ye ZHU, Qun CHEN, Ming-yang HE, Gui-bao WU, Ze-yun WANG. Research on the Methods for Determination of Molecular Weight of Poly(glycolic acid). [J]. Polymer Bulletin 25(8):98-104(2012)
DOI：

Jun-kai TIAN, Ai-jun CUI, Wei-liang LU, Ye ZHU, Qun CHEN, Ming-yang HE, Gui-bao WU, Ze-yun WANG. Research on the Methods for Determination of Molecular Weight of Poly(glycolic acid). [J]. Polymer Bulletin 25(8):98-104(2012) DOI：

摘要

基于目前测定聚羟基乙酸(PGA)分子量的常见方法:DMSO重结晶和急速冷却法

分别制得了两种待测样品。通过DSC、XRD表征了处理前后样品熔点、晶型、结晶度和晶粒大小的变化

比较了两种处理方法对PGA特性粘度的影响

考察了非晶态PGA在六氟异丙醇中的稳定性。结果表明:急速冷却法得到非晶态PGA可以有效地避免PGA在DMSO中的热降解情况

有利于准确测量PGA分子量;非晶态PGA在六氟异丙醇中降解速度较快

测分子量时

应当现配现测。根据Mark-Houwink方程

拟合了重均相对分子量和特性粘度之间关系Ln(η)=- 10.90* Ln(M

)+0.96

线性相关系数r=0.995

可以利用该方程通过测量PGA的特性粘度值来估算其重均相对分子量。

Abstract

Based on the molecular determination methods of DMSO recrystallization and rapid cooling

two poly(glycolic acid) samples had been prepared. By the tests of DSC and XRD

the change of the crystal sizes and the degree of crystallinity of the samples were discussed

and the intrinsic viscosities of the different samples were measured and compared. The stability of the samples in hexafluoroisopropanol was also investigated. A series of results showed that the rapid cooling was effective to avoid the PGA’s thermal degradation in DMSO; because the PGA degraded rapidly in HFIP solvent

the measurement of molecular weight should be carried out quickly after the PGA sample solvent was prepared. According to the Mark-Houwink equation

the relationship between the weight average molecular weight and intrinsic viscosity was built as: Ln(η)=-10.90*Ln(M

) +0.96

r=0.995. The weight average molecular weight could be calculated by the determination of intrinsic viscosity due to this equation.

关键词

PGADMSO重结晶急速冷却分子量

Keywords

Poly(glycolic acid)Recrystallization of DMSORapid coolingMolecular weight

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