Progress in Porous Scaffolds Fabricated by Porogen Leaching Method for Tissue Engineering

Chun-qing LI; Yu-gang ZHANG; Xing-hou GONG; Gao-wen ZHANG; Jiu-xin JIANG; Jia-ning LIU

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Progress in Porous Scaffolds Fabricated by Porogen Leaching Method for Tissue Engineering

更新时间：2022-09-18

- Progress in Porous Scaffolds Fabricated by Porogen Leaching Method for Tissue Engineering
- Polymer Bulletin Vol. 25, Issue 11, Pages: 92-96(2012)
- 作者机构：
  
  湖北工业大学化学与环境工程学院，武汉　430068
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012-11，
  
  Received：24 February 2012，
  
  Revised：09 May 2012，
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Chun-qing LI, Yu-gang ZHANG, Xing-hou GONG, Gao-wen ZHANG, Jiu-xin JIANG, Jia-ning LIU. Progress in Porous Scaffolds Fabricated by Porogen Leaching Method for Tissue Engineering. [J]. Polymer Bulletin 25(11):92-96(2012)
DOI：

Chun-qing LI, Yu-gang ZHANG, Xing-hou GONG, Gao-wen ZHANG, Jiu-xin JIANG, Jia-ning LIU. Progress in Porous Scaffolds Fabricated by Porogen Leaching Method for Tissue Engineering. [J]. Polymer Bulletin 25(11):92-96(2012) DOI：

摘要

粒子沥滤法作为常用的制备组织工程支架的方法

这种方法对实验设备和实验条件要求较低

孔隙率、孔径可控。但传统的溶液浇铸/粒子沥滤法也存在一些缺点

只适合制备薄层支架

孔-孔连通性不好

聚合物有可能保留致孔剂和/或有毒溶剂。本文总结了近几年科研工作者对这种方法所进行的改进工作

并探讨了改进的效果和不足。

Abstract

Porogen leaching method is most commonly used for fabricating micro- and macro-porous polymer scaffolds. The advantage of this method is that the process is easy to carry out and easy to control the pore size and porosity by selecting suitable particle size and amount of the added salt particles. However

most of the scaffolds prepared by this method are limited to two-dimensional films with 2~3mm

and the scaffolds usually have a poor interconnectivity between macropores. Moreover

the porogen and solvent can remain in polymer scaffolds. The development situation of modified porogen leaching method is reviewed in this paper

and the effects and deficiencies of the modification are discussed.

关键词

粒子沥滤多孔支架组织工程

Keywords

Porogen leachingPorous scaffoldTissue engineering

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