Chitosan-based Nanocarriers for Drug Delivery

Jun-lei ZHOU; Jin-jin DING; Hai-wen ZHANG; Li-qun WANG; Ke-hua TU

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Chitosan-based Nanocarriers for Drug Delivery

更新时间：2022-09-18

- Chitosan-based Nanocarriers for Drug Delivery
- Polymer Bulletin Vol. 25, Issue 5, Pages: 23-29(2012)
- 作者机构：
  
  浙江大学高分子科学与工程学系，教育部高分子合成与功能构造重点实验室，杭州　310027
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012-05，
  
  Received：27 September 2011，
  
  Revised：29 October 2011，
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Jun-lei ZHOU, Jin-jin DING, Hai-wen ZHANG, Li-qun WANG, Ke-hua TU. Chitosan-based Nanocarriers for Drug Delivery. [J]. Polymer Bulletin 25(5):23-29(2012)
DOI：

Jun-lei ZHOU, Jin-jin DING, Hai-wen ZHANG, Li-qun WANG, Ke-hua TU. Chitosan-based Nanocarriers for Drug Delivery. [J]. Polymer Bulletin 25(5):23-29(2012) DOI：

摘要

壳聚糖作为天然高分子材料，不仅安全无毒、而且具有良好的生物相容性、可生物降解性等优点，在药物传递领域作为纳米载体倍受关注。壳聚糖基纳米载体材料制备条件简单温和，近年来，其相关研究也颇为新颖。本文以载体形成的驱动力作为切入点，从共价交联、离子相互作用、聚电解质络合物和疏水改性四个方面，总结不同种类壳聚糖基纳米载体的构筑方法，同时介绍该载体对药物传递中载药量、载药率、释放行为以及细胞毒性等方面的影响，在此基础上展望其未来的应用前景。

Abstract

As a nature polymer

chitosan has been attracted more and more attention in drug delivery systems because of its outstanding properties

such as non-toxic

biodegradable and biocompatible. Chitosan based nanocarriers can be prepared easily

and recently

the researches of these nanocarries are very novel too. On the basis of the propulsion to formulate nanocarriers

the review is to summerize the latest preparation of modified chitosan derivatives from four aspects:covalent crosslinking

ionic crosslinking

polyelectrolyte complex

and the self-assembly of hydrophobically modi? ed chitosan. And the review is to introduce the effect on drug delivery of drug loading content

drug loading efficiency

release behavior and cytotoxicity

furthermore

outlook the future application.

关键词

壳聚糖纳米载体药物传递体系

Keywords

ChitosanNanocarrierDrug delivery

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