With the development of mechanochemistry and polymer materials

design of novel polymer materials to achieve mechanical response becomes important. One of the key issues of designing mechano-responsive materials is to discover novel mechanophores

which can be mechanochemically mediated to induce chemical transformation. This review will focus on the mechanochemical transformation of mechanophores

such as the break and formation of covalent bonds and the non-covalent interactions. In the case of covalent bonds

we focus on the inducing stimuli

such as sonication

tension and pressure; in the case of non-covalent interactions

different kinds of non-covalent interactions

such as hydrogen bonding and π-π interaction are discussed. With a better understanding of mechanochemical mechanisms and mechanophore design

more novel functional materials can be developed. We believe that research on mechanochemistry will offer a unique opportunity for the development of polymer materials.