Preparation and Hemostatic Performance of Calcium Alginate Porous Microspheres-bletilla Striata Polysaccharide Composite Hemostatic Powder

Chao WANG; Wen-feng LUO; Pu-wang LI; Si-dong LI; Zi-ming YANG; Zhang HU; Ning-jian AO

doi:10.14028/j.cnki.1003-3726.2017.07.009

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Preparation and Hemostatic Performance of Calcium Alginate Porous Microspheres-bletilla Striata Polysaccharide Composite Hemostatic Powder

更新时间：2022-09-06

- Preparation and Hemostatic Performance of Calcium Alginate Porous Microspheres-bletilla Striata Polysaccharide Composite Hemostatic Powder
- Polymer Bulletin Vol. 30, Issue 7, Pages: 63-69(2017)
- 作者机构：
  
  1.暨南大学生命科学技术学院，广州 510632
  2.中国热带农业科学院农产品加工研究所，湛江 524001
  3.广东海洋大学化学与环境学院，湛江 524088
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2017.07.009
  CLC：
- Published：01 July 2017，
  
  Received：07 November 2016，
  
  Revised：06 June 2017，
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Chao WANG, Wen-feng LUO, Pu-wang LI, Si-dong LI, Zi-ming YANG, Zhang HU, Ning-jian AO. Preparation and Hemostatic Performance of Calcium Alginate Porous Microspheres-bletilla Striata Polysaccharide Composite Hemostatic Powder. [J]. Polymer Bulletin 30(7):63-69(2017)
DOI：

Chao WANG, Wen-feng LUO, Pu-wang LI, Si-dong LI, Zi-ming YANG, Zhang HU, Ning-jian AO. Preparation and Hemostatic Performance of Calcium Alginate Porous Microspheres-bletilla Striata Polysaccharide Composite Hemostatic Powder. [J]. Polymer Bulletin 30(7):63-69(2017) DOI： 10.14028/j.cnki.1003-3726.2017.07.009.

摘要

海藻酸盐具有良好的生物相容性、可降解性、止血、抗菌、促愈合等特性，而中药白芨中的白芨多糖具有收敛止血、消肿生肌的功效。用海藻酸盐和白芨多糖为原料，采用冷冻干燥技术制备海藻酸钙多孔微球-白芨多糖复合止血粉，对其吸水速率进行考核，并采用体外凝血和动物出血模型实验进行止血性能评价。结果表明，致孔剂的添加量为0.5%的海藻酸钙多孔微球，当其与白芨多糖的质量比1：1时制备的止血粉的止血效果最好。

Abstract

Alginate has good biocompatibility

biodegradability

hemostatic

antimicrobial properties and promoting healing of wounds. As a kind of polysaccharides in Bletilla striata

a traditional Chinese medicine

Bletilla striata polysaccharide has the function of hemostasis

detumescence and can promote the granulation. In this study

alginate and Bletilla striata polysaccharide were used as raw material

and the composite hemostatic powder was prepared by using lyophilization method. The water absorption rate was measured

and the hemostatic performance was evaluated by using in vitro blood coagulation test and the bleeding animal model. The results indicated that when the amount of porogen in calcium alginate porous microspheres was 0.5%

and the mass ratio of calcium alginate porous microspheres with Bletilla striata polysaccharide was 1∶1

the composite powder showed the best hemostatic effect.

关键词

海藻酸盐微球白芨多糖止血

Keywords

AlginateMicrospheresBletilla striata polysaccharideHemostasis

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