Tumor Targeted pH-Sensitive ZnO QDs: Preparation, Characterization and Controlled Release of DOX

Ying-ying WEI; Xing-jun WU; Wen-tao HE; Ping SHI; Jian-chao YUAN

doi:10.14028/j.cnki.1003-3726.2018.03.007

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Tumor Targeted pH-Sensitive ZnO QDs: Preparation, Characterization and Controlled Release of DOX

更新时间：2022-09-05

- Tumor Targeted pH-Sensitive ZnO QDs: Preparation, Characterization and Controlled Release of DOX
- Polymer Bulletin Vol. 31, Issue 3, Pages: 53-58(2018)
- 作者机构：
  
  西北师范大学　化学化工学院　甘肃省高分子材料重点实验室，兰州　730070
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2018.03.007
  CLC：
- Published：20 March 2018，
  
  Received：01 June 2017，
  
  Revised：21 November 2017，
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Ying-ying WEI, Xing-jun WU, Wen-tao HE, Ping SHI, Jian-chao YUAN. Tumor Targeted pH-Sensitive ZnO QDs: Preparation, Characterization and Controlled Release of DOX. [J]. Polymer Bulletin 31(3):53-58(2018)
DOI：

Ying-ying WEI, Xing-jun WU, Wen-tao HE, Ping SHI, Jian-chao YUAN. Tumor Targeted pH-Sensitive ZnO QDs: Preparation, Characterization and Controlled Release of DOX. [J]. Polymer Bulletin 31(3):53-58(2018) DOI： 10.14028/j.cnki.1003-3726.2018.03.007.

摘要

聚丙烯酸(PAA)接枝聚乙二醇(PEG)和叶酸(FA)形成含有羧基的聚合物PAA-PEG-FA，与氨基修饰的ZnO量子点(ZnO QDs)表面的氨基通过静电作用过，形成具有肿瘤靶向pH响应的ZnO@(PAA-PEG- FA)核/壳纳米粒子(量子点为核，聚合物为壳)，抗癌药物阿霉素(DOX)通过配位形成肿瘤靶智能释药/显像体系：ZnO@(PAA-PEG-FA)-DOX(量子点的荧光可示踪/显像药物递送过程)。核磁共振(

H-NMR)和红外光谱测试结果表明，PAA-PEG-FA聚合物和氨基ZnO QDs通过静电引力组合为核/壳纳米粒子；透射电镜 (TEM)测得该体系呈规整球形且分布均匀，平均粒径约10nm；体外模拟释放结果表明，载药体系在癌细胞的溶酶体/内涵体(pH 5)内能很好地释放出阿霉素，而在药物输送过程(pH 7.4)中只有很少的阿霉素释放出来。因此，该肿瘤靶向pH响应型ZnO纳米颗粒作为抗癌药物载体具有潜在的应用价值。

Abstract

A novel tumor targeted pH-sensitive ZnO@ (Polyacrylic acid-polyethylene glycol-Folic acid ( ZnO@ ( PAA- PEG-FA)) QDs was formed by electrostatic interaction of the carboxyl of PAA-PEG-FA and amino of ZnO QDs. Doxorubicin (DOX) was loaded on the ZnO@ (PAA-PEG-FA) QDs through coordination to form drug controlled release/ imaging QDs

ZnO@ (PAA-PEG-FA)-DOX. PAA-PEG-FA polymer and ZnO QDs were characterized by

H-NMR and IR. Transmission electron microscopy (TEM) showed that the ZnO@(PAA-PEG-FA) QDs were spherical with an average diameter of about 10nm. The results of DOX release show that DOX released well from ZnO@ (PAA-PEG-FA) QDs in lysosomes/endosomes of cancer cell (pH 5)

and only little DOX released in the process of drug delivery ( pH 7. 4). Therefore

the tumor targeted pH responsive ZnO QDs have potential application as anticancer drug carriers.

关键词

ZnO量子点叶酸静电作用DOXpH敏感控制释放

Keywords

ZnO quantum dotsFolic acidElectrostatic interactionsDOXpH SensitiveControlled release

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