In this paper

the pH-responsive hydrogels with self-healing properties were rapidly constructed by introducing dynamic chemical acylhydrazone bonds. Firstly

the cross-linkage(β-CD-(NH2)7) with certain seven reactional points were synthesized by the reaction of iodine

azide and amination of whole 6-OH of β-cyclodextrin. Then

benzaldehyde-terminated polyethylene glycol(PEG-FA) was synthesized by esterification of polyethylene glycol and pcarboxybenzaldehyde. Fourier transform infrared spectroscopy(FT-IR)

1H-NMR

13C-NMR and matrix-assisted laser desorption ionization time-of-flight mass spectrometry(Maldi-TOF-MS) were used to characterize the products. Secondly

the pH response hydrogels based on reversible dynamic chemical bond were prepared by schiff base reaction of β-CD- (NH2)7 and PEG-FA. The lowest gel concentration

sol-gel transition and self-healing ability of the hydrogel were also studied. Through the response of external pH

the reversible chemical bonds can be broken and recombined

and the dynamic equilibrium relationship between reactants and generators can be established to complete the hydrogel formationbreakage- healing process. Basic cell experiments can also prove the potential application of the synthesized hydrogel.