Progress of <italic style="font-style: italic">In situ</italic> Polymerization within Cellular Microenvironment in Biomedical Applications

REN Hai-yan; MA Teng; LV Nian-nian; JIANG Hao; ZHU Jin-tao

doi:10.14028/j.cnki.1003-3726.2023.11.005

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Progress of In situ Polymerization within Cellular Microenvironment in Biomedical Applications

Special Issue: Polymer Research at Huazhong University of Science and Technology | 更新时间：2023-10-12

- Progress of In situ Polymerization within Cellular Microenvironment in Biomedical Applications
- Polymer Bulletin Vol. 36, Issue 11, Pages: 1438-1453(2023)
- 作者机构：
  
  华中科技大学化学与化工学院，武汉　430074
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2023.11.005
  CLC：
- Published：20 November 2023，
  
  Received：07 June 2023，
  
  Revised：05 July 2023，
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REN Hai-yan, MA Teng, LV Nian-nian, JIANG Hao, ZHU Jin-tao. Progress of In situ Polymerization within Cellular Microenvironment in Biomedical Applications. [J]. Polymer Bulletin 36(11):1438-1453(2023)
DOI：

REN Hai-yan, MA Teng, LV Nian-nian, JIANG Hao, ZHU Jin-tao. Progress of In situ Polymerization within Cellular Microenvironment in Biomedical Applications. [J]. Polymer Bulletin 36(11):1438-1453(2023) DOI： 10.14028/j.cnki.1003-3726.2023.11.005.

摘要

生物大分子都是通过小分子模块在细胞内聚合而成的，生物分子在细胞内的聚合反应在控制细胞功能方面发挥着重要作用。因此，将聚合反应从实验室烧瓶转移到细胞微环境中，通过化学反应合成非天然聚合物，有望成为调节细胞功能的一个强大而通用的工具。由于人工合成的非天然聚合物具有多样性和可调性，细胞微环境内的原位聚合反应可能为理解、分析和调节细胞功能带来巨大的可能性，在生物医学领域中具有巨大的潜力。本综述重点阐述了外源或内源性刺激(如光、谷胱甘肽、活性氧、酶等)在细胞微环境中引发的原位聚合反应机理，简单介绍了细胞微环境中的原位聚合在抗肿瘤治疗、神经修复以及抗菌领域的应用。最后，探讨了原位聚合面临的挑战，并展望了其未来的发展方向。

Abstract

All the important biomacromolecules in cells are formed by the polymerization of small molecular monomers. Polymerization within cellular microenvironment is very common and important in cell metabolism. Thus

transfer of polymerization reactions from laboratory flasks to cellular microenvironment is expected to be a powerful and versatile tool for regulation of cellular function. Owing to the diversity and tunability of polymers

in situ

polymerization in cellular microenvironment may bring great possibilities for understanding

analysis and regulation of cellular function

which has great potential in the field of biomedicine. In this review

we summarize and classify

in situ

polymerization triggered by exogenous or endogenous stimuli (such as light

glutathione

reactive oxygen species

enzymes

etc

.) in the cell microenvironment. The applications of

in situ

polymerization in the field of antitumor therapy

nerve repair and antimicrobe are briefly introduced. Finally

the key challenges of

in situ

polymerization in organisms are discussed

and its future development is proposed.

关键词

原位聚合细胞微环境外/内源性刺激生物医学应用

Keywords

In situ polymerizationCellular microenvironmentExogenous/endogenous stimuliBiomedical applications

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School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology

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Progress of In situ Polymerization within Cellular Microenvironment in Biomedical Applications

DOI：10.14028/j.cnki.1003-3726.2023.11.005

摘要

Abstract

关键词

Keywords

references