Research Progress on Preparation Technology and Application of Microcapsules

MA Guo-yan; WEI Wen-jing; LI Yang; HE Wei-jin

doi:10.14028/j.cnki.1003-3726.2025.24.311

您当前的位置：

首页 >

文章列表页 >

Research Progress on Preparation Technology and Application of Microcapsules

更新时间：2025-04-29

- Research Progress on Preparation Technology and Application of Microcapsules
- Polymer Bulletin Vol. 38, Issue 5, Pages: 718-726(2025)
- 作者机构：
  
  1.西安石油大学化学化工学院，西安 710065
  2.延长油田股份有限公司吴起采油厂，延安 717600
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2025.24.311
  CLC：
- Received：16 October 2024，
  
  Accepted：2024-12-09，
  
  Published Online：13 January 2025，
  
  Published：20 May 2025
- 稿件说明：
移动端阅览
马国艳, 魏雯婧, 李洋, 何纬晋. 微胶囊制备技术与应用研究进展. 高分子通报, 2025, 38(5), 718–726.

Ma, G. Y.; Wei, W. J.; Li, Y.; He, W. J. Research progress on preparation technology and application of microcapsules. Polym. Bull. (in Chinese), 2025, 38(5), 718–726.
马国艳, 魏雯婧, 李洋, 何纬晋. 微胶囊制备技术与应用研究进展. 高分子通报, 2025, 38(5), 718–726. DOI： 10.14028/j.cnki.1003-3726.2025.24.311.

Ma, G. Y.; Wei, W. J.; Li, Y.; He, W. J. Research progress on preparation technology and application of microcapsules. Polym. Bull. (in Chinese), 2025, 38(5), 718–726. DOI： 10.14028/j.cnki.1003-3726.2025.24.311.

摘要

微胶囊技术作为一种重要的包封与控制释放手段，近年来得到了广泛关注。本文系统地介绍了微胶囊的制备方法及其在各个领域的应用进展。微胶囊的制备方法根据其制备机理分为乳化-凝聚法、喷雾干燥法、喷雾干燥-冷冻法、相分离法、界面聚合法、原位聚合法和共沉淀法。不同的制备方法适用的范围不同，需要根据芯材与壁材体系选择合适的制备方法。本文还详细总结了微胶囊技术在医药、食品、化妆品、农业、纺织业、环境保护及新材料开发等领域的现状与发展趋势。微胶囊技术在提升产品稳定性、靶向控制以及研发功能性产品性能等方面展现出巨大的应用潜力，为微胶囊技术的未来发展提供了参考与借鉴。

Abstract

Microencapsulation technology

as an important method for encapsulation and controlled rele-ase

has received widespread attention in recent years. This article provides a systematic review of the preparation methods of microcapsules and their application advancements across various fields. The preparation methods of microcapsules are divided into emulsification-coagulation

spray drying

spray drying-frozen

phase separation

interfacial polymerization

in situ

polymerization

and co-precipitation according to the preparation mechanism. Different preparation methods have different scopes of application

and it is necessary to choose the appropriate preparation method according to the core material and shell material systems. This work also summarizes the current status and development trends of microencapsulation technology in the fields of medicine

food

cosmetics

agriculture

textile industry

environmental protection and new material development. Microencapsulation technology shows great potential in improving product stability

targeting control and developing functional product performance

which provides a reference for the future development of microencapsulation technology.

关键词

Keywords

references

Zhang, X. R. ; Han, Z. Y. ; Wang, C. ; Wu, B. B. ; Ren, Y. B. ; Liu, Y. J. ; Wu, X. ; Yang, J. ; Zi, R. C . Suppression of black powder combustion and explosion using novel green seawater microcapsules . J. Therm. Anal. Calorim. , 2024 , 149 ( 8 ), 3367 – 3378 .

Yu, H. Y. ; Wang, Y. X. ; Wang, R. Z. ; Hu, L. T. ; Wang, T. L . Performance and application of double-layered mic-rocapsule corrosion inhibitors . J. Wuhan Univ. Technol. Mater. Sci. Ed. , 2024 , 39 ( 4 ), 845 – 853 .

Ahmed, A. ; Ali, A. ; Alzahrani, B. ; Sanada, K . Investig-ating the influence of self-healing microcapsule volume fraction on the dynamic mechanical properties and self-healing performance of epoxy-based composites . J. Polym. Res. , 2024 , 31 ( 7 ), 201 .

Ji, M. ; Yue, F. ; He, Y. P. ; Yang, L. Z. ; Wang, H. R . Prep-aration and performance assessment of high-strength polyurea microcapsules . Powder Technol. , 2024 , 432 , 119173 .

Yan, C. E. ; Kim, S. R . Microencapsulation for pharma-ceutical applications: a review . ACS Appl. Bio Mater. , 2024 , 7 ( 2 ), 692 – 710 .

Xu, N. C. ; Ding, Y. ; Li, Y. ; Zhou, T. ; Ye, S. H . Prepa-ration and characterization of vitamin A microcapsules nutrient fortified salt . J. Food Sci. Technol. , 2024 , 61 ( 6 ), 1201 – 1213 .

Saeidy, S. ; Keramat, J. ; Nasirpour, A . Microencap-sulation of calcium using water-in-oil-in-water double emulsion method . J. Dispers. Sci. Technol. , 2014 , 35 ( 3 ), 370 – 379 .

陈蔚燕 , 高明惠 , 陈泳汀 , 辛露露 , 郑桂玲 , 徐晓庆 , 曲田丽 , 张保华 . B.t.微胶囊的喷雾干燥制备工艺优化及性能评价 . 农药 , 2024 , 63 ( 7 ), 494 – 499 .

Weng, Y. L. ; Xu, X. ; Yan, P. H. ; You, J. K. ; Chen, X. J. ; Song, H. ; Zhao, C. X . Enzyme encapsulation in metal-organic frameworks using spray drying for enhanced stability and controlled release: a case study of phytase . Food Chem. , 2024 , 452 , 139533 .

Yang, M. M. ; Li, L. L. ; Zhu, X. M. ; Liang, L. D. ; Chen, J. L. ; Cao, W. W. ; Liu, W. C. ; Duan, X. ; Ren, G. Y. ; Liu, Z. B . Microencapsulation of fish oil by spray drying, spray freeze-drying, freeze-drying, and microwave freeze-drying: microcapsule characterization and storage stability . J. Food Sci. , 2024 , 89 ( 6 ), 3276 – 3289 .

王精精 . 喷雾冷冻干燥惰性颗粒相变微胶囊的制备与应用 . 硕士学位论文 , 天津 : 天津科技大学 , 2023 .

霍麒文 . 水相分离法制备植物乳杆菌LIP-1微胶囊性能的研究 . 硕士学位论文 , 呼和浩特 : 内蒙古农业大学 , 2018 .

Meng, Y. W. ; Nicol, E. ; Nicolai, T . Exploiting multiple phase separation to stabilize water in water emulsions and form stable microcapsules . J. Colloid Interface Sci. , 2022 , 617 , 65 – 72 .

Bendic, V. ; Dobrotă, D. ; Dobrescu, T. ; Enciu, G. ; Pascu, N. E . Rheological issues of phase change materials obtained by the complex coacervation of butyl stearate in poly methyl methacrylate membranes . Energies , 2019 , 12 ( 5 ), 917 .

Han, Y. ; Li, J. ; Shi, W. ; Wang, C. Y. ; Ren, Q . SMA/PUA based double-layer thermo-expandable microcapsules and their performances . J. Polym. Res. , 2024 , 31 ( 4 ), 108 .

Chen, G. ; Shangguan, W. J. ; Chen, H. P. ; Xu, C. L. ; Bilal, M. ; Zhao, P. Y. ; Cao, C. ; Yu, M. L. ; Huang, Q. L. ; Cao, L. D . Chitooligosaccharide modified pesticide-loaded polyurethane microcapsules to mitigate drought stress in wheat . Chem. Eng. J. , 2024 , 479 , 147688 .

Zhang, Y. H. ; Zhang, X. ; Yan, Y. R. ; Chen, Z. H . Microe-ncapsulation of photochromic solution with polyurea by interfacial polymerization . Polymers , 2021 , 13 ( 18 ), 3049 .

Wang, Y. Y. ; Tan, Y. Q . Preparation, with graphene, of novel biomimetic self-healing microcapsules with high thermal stability and conductivity . Front. Struct. Civ. Eng. , 2023 , 17 ( 8 ), 1188 – 1198 .

Yang, K. ; Niu, Y. P. ; Li, Y. ; Wang, X. W. ; Du, S. M. ; Zhang, Y. Z . Preparation of microcapsules using ionic liquid and their tribological behavior for epoxy com-posites . J. Mater. Sci. , 2024 , 59 ( 9 ), 3890 – 3903 .

Han, S. J. ; Li, J. P. ; Ding, Q. Y. ; Zang, J. ; Lu, Y. L. ; Zhang, L. F. ; Hu, L . Effects of processing conditions on the properties of monoammonium phosphate microcapsules with melamine-formaldehyde resin shell . Polymers , 2023 , 15 ( 14 ), 2991 .

Kong, P. F. ; Abe, J. P. ; Masuo, S. ; Enomae, T . Prepa-ration and characterization of tea tree oil- β -cyclodextrin microcapsules with super-high encapsulation efficiency . J. Bioresour. Bioprod. , 2023 , 8 ( 3 ), 224 – 234 .

Cheng, J. J. ; Liang, C. C. ; Lin, W. ; Zeng, J. L. ; Li, C. J. ; Li, S. X. ; Zhang, F. ; Wang, Y. P . Preparation and characterization of phase change material microcapsules with carbon nanotubes loaded with MgAl layered double hydroxides for controlling temperature in the building . J. Energy Storage , 2024 , 80 , 110357 .

Liu, H. ; Chen, D. Y. ; Yang, X. H. ; Zhao, M. ; Zhong, J. ; Ding, W. J. ; Hu, W. G. ; Yang, H. Y. ; Wang, Z. T. ; He, Q. J . Intestine-targeted controlled hydrogen-releasing MgH 2 microcapsules for improving the mitochondrial metabolism of inflammatory bowel disease . Adv. Funct. Mater. , 2024 , 34 ( 33 ), 2316227 .

Jinn, Y. ; Lv, H. J. ; Cui, C. D. ; Wang, M. Z. ; He, W. ; Cui, L. H. ; Yan, C. G . Preparation and in vitro performance evaluation of egg yolk immunoglobulin-loaded sodium alginate/chitosan/sodium alginate microcapsules for feeding . J. Anim. Plant Sci. , 2024 , 34 ( 3 ), 696 – 707 .

Zhang, J. ; Zhang, M. ; Wang, Y. C. ; Bhandari, B. ; Wang, M. Q . Oral soluble shell prepared from OSA starch incor-porated with tea polyphenols for the microencapsulation of Sichuan pepper oleoresin: characterization, flavor stability, release mechanisms and its application in mooncake . Food Chem. , 2024 , 451 , 139478 .

Li, Z. A. ; Jiang, L. W. ; Wang, Y. Y. ; Li, M. ; Liu, T. T. ; Liu, Y. Z . Chitosan‒gellan gum polyelectrolyte hydrogel beads containing tea tree oil microcapsules: preparation, characterization and application . Food Hydrocoll. , 2024 , 157 , 110464 .

Łętocha, A. ; Michalczyk, A. ; Ostrowska, P. ; Miastko-wska, M. ; Sikora, E . Probiotics-loaded microspheres for cosmetic applications . Appl. Sci. , 2024 , 14 ( 3 ), 1183 .

Yu, X. C. ; Zhao, Y. H. ; Chen, G. ; Yu, J. ; Wang, R. L. ; Deng, Y. H. ; Wang, X. Y. ; Yuan, X. R. ; Yu, X. F. ; He, R . Preparation and characterization of titanium oxide nanocapsules containing retinoic acid for sustained release . J. Clust. Sci. , 2024 , 35 ( 2 ), 419 – 428 .

Maruyama, T. ; Ishibashi, Y. ; Sano, M. ; Yoshimura, H. ; Taguchi, Y . Simulation and application assessment of the efficacy of fosthiazate-loaded microcapsules against root-knot nematode . Pest Manag. Sci. , 2024 , 80 ( 10 ), 5078 – 5087 .

Wang, R. ; Zhang, J. ; Sun, Z. Y. ; Jian, X. W. ; Xu, Y. ; Zhou, X. ; Liang, X. J. ; Lin, J. ; Li, B. X. ; Mu, W. ; Li, Y. K . Eucalyptol-loaded microcapsules combined with Cynanchum komarovii extracts provide long-term and low-risk management of Chinese wolfberry (Lycium barbarum L.) . Ecotoxicol. Environ. Saf. , 2024 , 270 , 115874 .

Vivek, S. ; Chakraborty, J. N . Application of chitosan encapsulated clove essential oil microcapsules on cotton fabrics for antibacterial finish . Indian J. Fibre Text. Res. , 2024 , 49 ( 2 ), 222 – 236 .

Verbič, A. ; Golja, B. ; Likozar, B. ; Novak, U. ; Stres, B . Biopolymer microencapsulation strategies for environm-entally friendly hydrophobic textile coatings . ISCRE28 , 2024 .

Yang, L. ; Meng, J. G. ; Yu, L. J. ; Gao, X. Y. ; Chen, Y. Q. ; Wang, Y. Z. ; Xue, T. ; Liu, Y. M. ; Zhi, C . Reversible dual-responsive color-changing fabric based on thermochromic microcapsules for textile fashion and intelligent monitoring . Dyes Pigm. , 2024 , 231 , 112397 .

Wei, Z. ; Zhu, J. X. ; He, Y. ; Lai, J. ; Pan, B. J. ; Feng, K. Y. ; Chen, L. H. ; Cao, L. D. ; Wang, Y. ; Qian, K . Improving the efficiency and environmental safety of emamectin benzoate through a pH-responsive metal–organic fram-ework microencapsulation strategy . J. Hazard. Mater. , 2024 , 475 , 134847 .

Ortega, P. ; Sánchez, E. ; Montornes, J. M. ; Tylkowski, B. ; Olkiewicz, M. ; Gil, E . Design and evaluation of microencapsulation technology to reduce the environ-mental impact of copper fungicides in vineyards . Crop Prot. , 2024 , 176 , 106502 .

莫嘉威 , 冉义建 , 陈通权 , 黄致锋 . 自修复型混凝土结构缝止水密封胶的制备与防水性能研究 . 中国建筑防水 , 2024 , 7 , 14 – 19 .

Huang, Q. ; Wang, S. L. ; He, J. C. ; Xu, D. J. ; Abdou, S. N. ; Ibrahim, M. M. ; Sun, S. Q. ; Chen, Y. J. ; Li, H. D. ; Ben, B. X. ; Liu, C. C. ; El-Bahy, Z. M. ; Guo, Z. H . Experimental design of paraffin/methylated melamine-formaldehyde microencapsulated composite phase change material and the application in battery thermal management system . J. Mater. Sci. Technol. , 2024 , 169 , 124 – 136 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research and Application Progress of Carboxymethyl Cellulose Based Composite Hydrogels

In situ Fabrication of High Performance Gel Electrolyte for Lithium Battery Based on Self-catalyzed Strategy

Progress of In situ Polymerization within Cellular Microenvironment in Biomedical Applications

Research Progress of Paraffin-based Microencapsulated Phase Change Materials

Related Author

MA Guo-yan

MO Li-juan

LIU Ying

XU Nai-chuang

ZHANG Jing-ling

LI Fen

GUO Kai-rui

XUE Zhi-gang

Related Institution

School of Materials, Liaoning Technical University

School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology

School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST)

School of Chemistry and Chemical Engineering, Northeast Petroleum University

College of Materials Science and Engineering,Qiqihar University

⁰