Progress on Poly(<italic style="font-style: italic">α</italic>-lipoic acid)-based Adhesive Hydrogels

LUO Zhen; LIU Wen-guang; CUI Chun-yan

doi:10.14028/j.cnki.1003-3726.2025.25.240

您当前的位置：

首页 >

文章列表页 >

Progress on Poly(α-lipoic acid)-based Adhesive Hydrogels

更新时间：2025-12-05

- Progress on Poly(α-lipoic acid)-based Adhesive Hydrogels
- Polymer Bulletin Vol. 38, Issue 12, Pages: 1789-1806(2025)
- 作者机构：
  
  天津大学材料科学与工程学院，贵金属功能材料全国重点实验室，天津 300350
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2025.25.240
  CLC：
- Received：25 August 2025，
  
  Accepted：26 September 2025，
  
  Published Online：14 November 2025，
  
  Published：20 December 2025
- 稿件说明：
移动端阅览
雒振, 刘文广, 崔春燕. 聚α-硫辛酸基黏附水凝胶的研究进展. 高分子通报, 2025, 38(12), 1789–1806.

Luo, Z.; Liu, W. G.; Cui, C. Y. Progress on poly(α-lipoic acid)-based adhesive hydrogels. Polym. Bull. (in Chinese), 2025, 38(12), 1789–1806.
雒振, 刘文广, 崔春燕. 聚α-硫辛酸基黏附水凝胶的研究进展. 高分子通报, 2025, 38(12), 1789–1806. DOI： 10.14028/j.cnki.1003-3726.2025.25.240.

Luo, Z.; Liu, W. G.; Cui, C. Y. Progress on poly(α-lipoic acid)-based adhesive hydrogels. Polym. Bull. (in Chinese), 2025, 38(12), 1789–1806. DOI： 10.14028/j.cnki.1003-3726.2025.25.240.

摘要

生物医用水凝胶黏合剂在组织修复、伤口闭合和药物递送等领域具有重要应用价值。因此，开发兼具高效黏附性、生物可降解性和良好生物安全性的新型水凝胶材料成为研究热点。硫辛酸(lipoic acid

LA)作为一种内源性抗氧化剂，其分子结构中的二硫键赋予其动态可逆的交联能力，同时具备抗炎、抗氧化应激等生物活性。近年来，基于聚硫辛酸的黏附水凝胶因其独特的动态共价化学特性与多重生物功能受到广泛关注。本文系统综述了硫辛酸的分子结构与生物功能、聚硫辛酸的室温稳定机理、水凝胶的构建方法及其在生物医学领域的应用，并对其面临的挑战与未来发展方向进行了展望，旨在为PolyLA基黏附水凝胶未来的理论突破与实践应用提供重要参考。

Abstract

Biomedical hydrogel adhesives have significant application value in fields such as tissue repair

wound closure

and drug delivery. Consequently

the development of novel hydrogel materials that combine high adhesion

biodegradability

and excellent biosafety has become a research focus. Lipoic acid (LA)

an endogenous antioxidant

possesses a disulfide bond in its molecular structure that confers dynamic reversible cross-linking capabilities

along with biological activities such as anti-inflammatory and antioxidant stress properties. In recent years

poly(lipoic acid) (PolyLA)-based adhesive hydrogels have attracted widespread attention owing to their unique dynamic covalent chemistry and multifunctional biological characteristics. This review systematically summarizes the molecular structure and biological functions of LA

room-temperature stabilization mechanisms of PolyLA

methods for constructing PolyLA-based hydrogels

and their applications in the biomedical field. It also discusses the existing challenges and future development directions

aiming to provide important references for the theoretical breakthroughs and practical applications of PolyLA-based adhesive hydrogels in the future.

关键词

Keywords

references

Wu, S. J. ; Zhao, X. H . Bioadhesive technology platforms . Chem. Rev. , 2023 , 123 ( 24 ), 14084 – 14118 .

Tang, S. X. ; Feng, K. R. ; Yang, R. ; Cheng, Y. ; Chen, M. Y. ; Zhang, H. ; Shi, N. Y. ; Wei, Z. ; Ren, H. ; Ma, Y. F . Multifunctional adhesive hydrogels: from design to biomedical applications . Adv. Healthc. Mater. , 2025 , 14 ( 2 ), 2403734 .

Liu, C. Y. ; Peng, K. X. ; Wu, Y. L. ; Fu, F. F . Functional adhesive hydrogels for biological interfaces . Smart Med. , 2023 , 2 ( 4 ), e20230024 .

Li, Z. C. ; Li, Y. Y. ; Zhang, Z. H. ; Cui, H. J. ; Ji, X. ; Wang, W. Y. ; Xu, M. L. ; Ren, H. X. ; Du, C. ; Liu, W. W. ; Wang, L . Physicochemical dual cross-linked multifunctional conductive organohydrogel sensors for fireworks burn wound healing and intelligent real-time monitoring . Polym. Sci. Technol. , 2025 , 1 ( 3 ), 245 – 260 .

Cui, C. Y. ; Liu, W. G . Recent advances in wet adhesives: adhesion mechanism, design principle and applications . Prog. Polym. Sci. , 2021 , 116 , 101388 .

An, B. Y. ; Cui, H. H. ; Wang, M. K. ; Li, Z. R. ; Li, J. G . Hydrogel tissue adhesive: adhesion strategy and application . Colloids Surf. B Biointerfaces , 2025 , 253 , 114755 .

Cui, H. H. ; Li, J. G . Hydrogel adhesives for tissue recovery . Adv. Colloid Interface Sci. , 2025 , 341 , 103496 .

Ouyang, C. G. ; Yu, H. J. ; Wang, L. ; Ni, Z. P. ; Liu, X. W. ; Shen, D. ; Yang, J. ; Shi, K. H. ; Wang, H. N . Tough adhesion enhancing strategies for injectable hydrogel adhesives in biomedical applications . Adv. Colloid Interface Sci. , 2023 , 319 , 102982 .

Chen, C. ; Yang, X. ; Li, S. J. ; Zhang, C. ; Ma, Y. N. ; Ma, Y. X. ; Gao, P. ; Gao, S. Z. ; Huang, X. J . Tannic acid-thioctic acid hydrogel: a novel injectable supramolecular adhesive gel for wound healing . Green Chem. , 2021 , 23 ( 4 ), 1794 – 1804 .

Cui, C. Y. ; Mei, L. ; Wang, D. Y. ; Jia, P. F. ; Zhou, Q. H. ; Liu, W. G . A self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer . Nat. Commun. , 2023 , 14 ( 1 ), 7707 .

Lv, S. Y. ; He, S. S. ; Ling, X. L. ; Wang, Y. Q. ; Huang, C. ; Long, J. R. ; Wang, J. Q. ; Qin, Y. ; Wei, H. ; Yu, C. Y . Review of lipoic acid: from a clinical therapeutic agent to various emerging biomaterials . Int. J. Pharm. , 2022 , 627 , 122201 .

Bellini, C. ; Mancin, F. ; Papini, E. ; Tavano, R . Nanotechnological approaches to enhance the potential of α -lipoic acid for application in the clinic . Antioxidants , 2024 , 13 ( 6 ), 706 .

Dugbartey, G. J. ; Alornyo, K. K. ; Dapaa-Addo, C. O. ; Botchway, E. ; Kwashie, E. K. ; Harley, Y . Alpha-lipoic acid: a promising pharmacotherapy seen through the lens of kidney diseases . Curr. Res. Pharmacol. Drug Discov. , 2024 , 7 , 100206 .

Fonte, J. ; Miklossy, J. ; Atwood, C. ; Martins, R . The severity of cortical Alzheimer's type changes is positively correlated with increased amyloid-beta levels: resolu-bilization of amyloid-beta with transition metal ion chelators . J. Alzheimers Dis. , 2001 , 3 ( 2 ), 209 – 219 .

Li, M. ; Ling, L. B. ; Xia, Q. ; Li, X. S . A reduction-responsive drug delivery with improved stability: disulfide crosslinked micelles of small amiphiphilic molecules . RSC Adv. , 2021 , 11 ( 21 ), 12757 – 12770 .

Li, W. T. ; Peng, J. R. ; Yang, Q. ; Chen, L. J. ; Zhang, L. ; Chen, X. X. ; Qian, Z. Y . α -Lipoic acid stabilized DTX/IR780 micelles for photoacoustic/fluorescence imagin g guided photothermal therapy/chemotherapy of breast cancer . Biomater. Sci. , 2018 , 6 ( 5 ), 1201 – 1216 .

Yang, K. ; Wang, Y. ; Li, Y. W. ; Chen, Y. G. ; Xing, N. ; Lin, H. B. ; Zhou, P. ; Yu, X. P . Progress in the treatment of diabetic peripheral neuropathy . Biomed. Pharmacother. , 2022 , 148 , 112717 .

Awoleye, M. O. ; Adedeji, T. G. . Revisiting the molecular mechanisms of alpha lipoic acid (ALA) actions on metabolism . Pharmacol. Res. Nat. Prod. , 2024 , 4 , 100073 .

Song, H. T. ; Fu, F. ; Chen, Y. Y. ; Yang, R. ; Luo, Z. ; Shao, J. X. ; Qi, Y. ; Zhang, Q. ; Wang, J. J. ; Sun, H. T. ; Cui, C. Y. ; Liu, W. G . A poly(lipoic acid)-based elastomer adhesive with synergistic activity of microenvironment regulation and peripheral neuropathy repair facilitates infectious diabetic wound healing . Biomaterials , 2026 , 324 , 123489 .

Sun, Y. G. ; Zhao, X. R. ; Yang, R. ; Xiao, M. ; Liu, W. G . α-Lipoic acid-based nanozyme for treating acute epilepsy . Adv. Funct. Mater. , 2025 , 35 ( 3 ), 2412633 .

Zhang, Q. ; Qu, D. H. ; Feringa, B. L. ; Tian, H . Disulfide-mediated reversible polymerization toward intrinsically dynamic smart materials . J. Am. Chem. Soc. , 2022 , 144 ( 5 ), 2022 – 2033 .

Song, H. T. ; Qi, Y. ; Luo, Z. ; Shao, J. X. ; Cui, C. Y. ; Liu, W. G . A salt-bridge hydrogen bond stabilized poly(lipoic acid)-based bioactive adhesive . Sci. China Technol. Sci. , 2025 , 68 ( 7 ), 1720201 .

Luo, Z. ; Zhao, Q. Q. ; Zhang, Y. M. ; Shao, J. X. ; Zhao, Y. H. ; Li, M. H. ; Dou, Y. M. ; Cui, C. Y. ; Yang, Q. ; Liu, W. G . Coral-inspired bioactive porous adhesive for fractured bone repair . Adv. Funct. Mater. , 2025 , DOI: 10.1002/adfm.202507592 https://doi.org/10.1002/adfm.202507592 .

Cui, C. Y. ; Sun, Y. G. ; Nie, X. F. ; Yang, X. X. ; Wang, F. S. ; Liu, W. G . A coenzyme-based deep eutectic supramolecular polymer bioadhesive . Adv. Funct. Mater. , 2023 , 33 ( 49 ), 2307543 .

Zhang, Q. ; Shi, C. Y. ; Qu, D. H. ; Long, Y. T. ; Feringa, B. L. ; Tian, H . Exploring a naturally tailored small molecule for stretchable, self-healing, and adhesive supramolecular polymers . Sci. Adv. , 2018 , 4 ( 7 ), eaat8192 .

Dikshit, K. V. ; Visal, A. M. ; Janssen, F. ; Larsen, A. ; Bruns, C. J . Pressure-sensitive supramolecular adhesives based on lipoic acid and biofriendly dynamic cyclodextrin and polyrotaxane cross-linkers . ACS Appl. Mater. Interfaces , 2023 , 15 ( 13 ), 17256 – 17267 .

Pal, S. ; Shin, J. ; DeFrates, K. ; Arslan, M. ; Dale, K. ; Chen, H. ; Ramirez, D. ; Messersmith, P. B . Recyclable surgical, consumer, and industrial adhesives of poly( α -lipoic acid). Science , 2024 , 385 ( 6711 ), 877 – 883 .

Yang, W. ; Zhong, W. W. ; Yan, S. T. ; Wang, S. T. ; Xuan, C. K. ; Zheng, K. ; Qiu, J. G. ; Shi, X. T . Mechanical stimulation of anti-inflammatory and antioxidant hydrogels for rapid re-epithelialization . Adv. Mater. , 2024 , 36 ( 18 ), 2312740 .

Reed, L. J. ; DeBusk, B. G. ; Gunsalus, I. C. ; Hornberger, C. S . Crystalline α -lipoic acid: a catalytic agent associated with pyruvate dehydrogenase . Science , 1951 , 114 ( 2952 ), 93 – 94 .

Wang, J. Q. ; Ling, X. ; Wang, H. J. ; Chen, F. E . α-Lipoic acid chemistry: the past 70 years . RSC Adv. , 2023 , 13 ( 51 ), 36346 – 36363 .

Uchida, R. ; Okamoto, H. ; Ikuta, N. ; Terao, K. ; Hirota, T . Investigation of enantioselective membrane permeability of α -lipoic acid in caco-2 and MDCKII cell . Int. J. Mol. Sci. , 2016 , 17 ( 2 ), 155 .

Pacini, A. ; Tomassoni, D. ; Trallori, E. ; Micheli, L. ; Amenta, F. ; Ghelardini, C. ; di Cesare Mannelli, L. ; Traini, E . Comparative assessment of the activity of racemic and dextrorotatory forms of thioctic (alpha-lipoic) acid in low back pain: preclinical results and clinical evidences from an open randomized trial . Front. Pharmacol. , 2021 , 12 , 607572 .

Liu, Q. X. ; Li, W. X. ; Huang, S. M. ; Zhao, L. H. ; Zhang, J. Y. ; Ji, C. ; Ma, Q. G . R - Is superior to S -form of α -lipoic acid in anti-inflammatory and antioxidant effects in laying hens . Antioxidants , 2022 , 11 ( 8 ), 1530 .

Gleiter, C. H. ; Schug, B. S. ; Hermann, R. ; Elze, M. ; Blume, H. H. ; Gundert-Remy, U . Influence of food intake on the bioavailability of thioctic acid enantiomers . Eur. J. Clin. Pharmacol. , 1996 , 50 ( 6 ), 513 – 514 .

Hermann, R. ; Mungo, J. ; Cnota, P. J. ; Ziegler, D . Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of various alpha-lipoic acid dosage forms . Clin. Pharmacol. , 2014 , 6 , 195 – 204 .

Shi, C. ; Sun, Y. ; Zhang, X. R. ; Zheng, Z. W. ; Yang, M. C. ; Ben, H. ; Song, K. K. ; Cao, Y. F. ; Chen, Y. F. ; Liu, X. ; Dong, R. ; Xia, X. D . Antimicrobial effect of lipoic acid against Cronobacter sakazakii. Food Control , 2016 , 59 , 352 – 358 .

Zhou, W. Y. ; Du, Y. W. ; Li, X. S. ; Yao, C . Lipoic acid modified antimicrobial peptide with enhanced antimicrobial properties . Bioorg. Med. Chem. , 2020 , 28 ( 19 ), 115682 .

Qi, Y. ; Xu, C. Y. ; Zhang, Z. D. ; Zhang, Q. ; Xu, Z. Y. ; Zhao, X. R. ; Zhao, Y. H. ; Cui, C. Y. ; Liu, W. G . Wet environment-induced adhesion and softening of coenzyme-based polymer elastic patch for treating periodontitis . Bioact. Mater. , 2024 , 35 , 259 – 273 .

Deore, M. S. ; Keerthana, S. ; Naqvi, S. ; Kumar, A. ; Flora, S. J. S. . Alpha-lipoic acid protects co-exposure to lead and zinc oxide nanoparticles induced neuro, immuno and male reproductive toxicity in rats . Front. Pharmacol. , 2021 , 12 , 626238 .

Fiedler, S. E. ; Spain, R. I. ; Kim, E. ; Salinthone, S . Lipoic acid modulates inflammatory responses of monocytes and monocyte-derived macrophages from healthy and relapsing-remitting multiple sclerosis patients . Immunol. Cell Biol. , 2021 , 99 ( 1 ), 107 – 115 .

Zhang, Z. D. ; Xia, Y. ; Li, X. Y. ; Zhang, Q. ; Wu, Y. H. ; Cui, C. Y. ; Liu, J. F. ; Liu, W. G . Arginine-solubilized lipoic acid-induced β-sheets of silk fibroin-strengthened hydrogel for postoperative rehabilitation of breast cancer . Bioact. Mater. , 2024 , 40 , 667 – 682 .

Lu, R. L. ; Zhou, X. D. ; Peng, K. ; Liu, C. ; Yuan, T. ; Li, P. F. ; Zhang, S. Y . High-density dynamic bonds cross-linked hydrogel with tissue adhesion, highly efficient self-healing behavior, and NIR photothermal antibacterial ability as dressing for wound repair . Biomacromolecules , 2024 , 25 ( 4 ), 2486 – 2496 .

Du, J. Q. ; Chen, T. T. ; Yu, J. ; Cheng, Y. L . Construction of nanohydroxyapatite/poly(sodium lipoate)-based bioactive hydrogels for cranial bone regeneration . Biomacromolecules , 2025 , 26 ( 1 ), 705 – 714 .

Wang, T. ; Fang, H. W. ; Yalikun, S. ; Li, J. Y. ; Pan, Y. Q. ; Zhang, K. X. ; Yin, J. B. ; Cui, H. Y . Pluronic F127-lipoic acid adhesive nanohydrogel combining with Ce 3+ /tannic acid/ulinastatin nanoparticles for promoting wound healing . Biomacromolecules , 2024 , 25 ( 2 ), 924 – 940 .

Zhou, Y. T. ; Liu, M. H. ; He, C. D. ; Lin, J. Y. ; Chen, Y. L. ; Yu, M. Y. ; Jiang, Y. H. ; Peng, X . Innovative liquid embolic agents based on deep eutectic solvent: rapid gelation in situ via solvent exchange with water for endovascular embolization . Bioact. Mater. , 2025 , 48 , 550 – 563 .

Chen, Y. L. ; Yu, M. ; Liu, M. H. ; Sun, Y. ; Ling, C. X. ; Yu, M. Y. ; Zhang, W. W. ; Zhang, W. K. ; Peng, X . A solvent exchange induced robust wet adhesive hydrogels to treat solid tumor through synchronous ethanol ablation and chemotherapy . Adv. Sci. , 2024 , 11 ( 24 ), 2309760 .

Ren, H. ; Zhang, Z. ; Cheng, X. L. ; Zou, Z. ; Chen, X. S. ; He, C. L . Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure . Sci. Adv. , 2023 , 9 ( 33 ), eadh4327 .

Tu, Y. J. ; Chen, N. ; Li, C. P. ; Liu, H. Q. ; Zhu, R. ; Chen, S. F. ; Xiao, Q. ; Liu, J. H. ; Ramakrishna, S. ; He, L. M . Advances in injectable self-healing biomedical hydrogels . Acta Biomater. , 2019 , 90 , 1 – 20 .

Wang, F. ; Du, J. Q. ; Qiao, H. ; Liu, D. F. ; Guo, D. ; Chen, J. J. ; Zhang, Y. F. ; Cheng, Y. L. ; He, X. J . Natural small molecule-induced polymer hydrogels with inherent antioxidative ability and conductivity for neurogenesis and functional recovery after spinal cord injury . Chem. Eng. J. , 2023 , 466 , 143071 .

Gao, Y. M. ; Zhan, X. ; Huo, S. H. ; Fu, L. ; Tang, Z. ; Qi, K. K. ; Lv, C. C. ; Liu, C. Y. ; Zhu, Y. L. ; Ding, S. G. ; Lv, Y. M . A gentamicin-thioctic acid multifunctional hydrogel for accelerating infected wound healing . J. Mater. Chem. B , 2022 , 10 ( 13 ), 2171 – 2182 .

Qi, Y. ; Shao, J. X. ; Luo, Z. ; Zhang, Q. ; Tian, X. ; Yang, R. ; Sun, Y. G. ; Chen, D. Y. ; Cui, C. Y. ; Liu, W. G . In vivo adhesion fault-tolerant coenzyme/queen bee acid nanomicelles self-crosslinked thermoresponsive adhesive hydrogel for efficient oral ulcer treatment . Bioact. Mater. , 2025 , 52 , 460 – 473 .

Shao, X. H. ; Yang, X. ; Zhou, Y. ; Xia, Q. C. ; Lu, Y. P. ; Yan, X. ; Chen, C. ; Zheng, T. T. ; Zhang, L. L. ; Ma, Y. N. ; Ma, Y. X. ; Gao, S. Z . Antibacterial, wearable, transparent tannic acid—thioctic acid—phytic acid hydrogel for adhesive bandages . Soft Matter , 2022 , 18 ( 14 ), 2814 – 2828 .

Chai, C. X. ; Zhang, P. F. ; Ma, L. ; Fan, Q. ; Liu, Z. C. ; Cheng, X. ; Zhao, Y. P. ; Li, W. W. ; Hao, J. C . Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair . Bioact. Mater. , 2023 , 25 , 541 – 554 .

Huang, T. T. ; Yang, M. ; Yuan, B. L. ; Liu, Y. ; Zhang, L. ; Tang, J . Conductive antibacterial/antioxidant hydrogel dressing for epidermal sensors and accelerated diabetic wound healing . Mater. Today Chem. , 2025 , 46 , 102720 .

Lei, R. ; Gu, M. B. ; Li, J. Y. ; Wang, W. J. ; Yu, Q. ; Ali, R. ; Pang, J. J. ; Zhai, M. L. ; Wang, Y. ; Zhang, K. X. ; Yin, J. B. ; Xu, J. H . Lipoic acid/trometamol assembled hydrogel as injectable bandage for hypoxic wound healing at high altitude . Chem. Eng. J. , 2024 , 489 , 151499 .

Wang, C. ; Yu, F. Z. ; Yuan, Y. ; Zhao, Z. ; Zhang, L. L . Biomimetic poly(thioctic acid)-based bioadhesive hydrogels for wet adhesion, expeditious hemostasis and enhanced wound healing . Int. J. Biol. Macromol. , 2024 , 283 , 137108 .

Tu, Y. S. ; Zheng, W. X. ; Ding, Z. C. ; Xiang, J. ; Yang, Q. F. ; Liu, Y. C. ; Cao, J. ; Shen, Y. L. ; Tang, Z. N. ; Lin, S. ; Fan, L. ; Xu, Y. W. ; Chen, B . Exosome-loaded tannic acid-thioctic acid hydrogel enhances wound healing in coagulation disorders . Mater. Today Bio , 2025 , 31 , 101496 .

Fan, X. W. ; Li, Z. ; Yue, M. X. ; Chen, M. L. ; Mao, K. ; Liu, Y. S. ; Jiang, W. ; Li, H . Adhesive two-dimensional bimetallic organic framework nanozymes for regulating inflammation and eradicating bacteria in periodontal disease . Chem. Eng. J. , 2025 , 517 , 164263 .

Liu, M. H. ; Wang, Y. Z. ; Chen, Y. L. ; Li, L. J. ; Sun, Y. ; Li, Y. C. ; Yuan, Y. J. ; Lu, P. ; Zhang, W. K. ; Pang, P. F. ; Peng, X. ; Shan, H . Solvent exchange induced in situ formed hydrogel as liquid embolic agents . Adv. Funct. Mater. , 2023 , 33 ( 45 ), 2305153 .

Chai, C. X. ; Guo, Y. Y. ; Huang, Z. H. ; Zhang, Z. ; Yang, S. ; Li, W. W. ; Zhao, Y. P. ; Hao, J. C . Antiswelling and durable adhesion biodegradable hydrogels for tissue repairs and strain sensors . Langmuir , 2020 , 36 ( 35 ), 10448 – 10459 .

Meng, J. ; Sun, J. J. ; Kang, J. L. ; Ren, S. L. ; Xu, M. M. ; Li, R. Z. ; Zhao, X. H. ; Yuan, Y. T. ; Xin, L. ; Zhang, R. P . Multifunctional hydrogels loaded with tellurium nanozyme for spinal cord injury repair . Mater. Today Bio , 2024 , 29 , 101339 .

Yang, X. X. ; Zhang, B. W. ; Li, J. J. ; Shen, M. G. ; Liu, H. ; Xu, X. ; Shang, S. B . Self-healing, self-adhesive, and stretchable conductive hydrogel for multifunctional sensor prepared by catechol modified nanocellulose stabilized poly(α-thioctic acid) . Carbohydr. Polym. , 2023 , 313 , 120813 .

Zhang, J. H. ; Zhong, J. ; Liang, B. ; Liu, W. J. ; Zhang, H. J. ; Wang, T. Y. ; Huang, L. P. ; Yang, L. ; Gu, Z. P. ; Li, Y. W . Robust injectable hydrogels for hemophilic arthropathy via anti-inflammation, iron removal and cartilage protection . Adv. Funct. Mater. , 2025 , 35 ( 36 ), 2500271 .

Cui, J. W. ; Su, X. S. ; Jiao, B. N. ; Xiang, W. ; Fang, Y. Y . Efficiently synthesized, multifunctional recyclable hydrogel for accelerated wound healing . ACS Appl. Polym. Mater. , 2024 , 6 ( 5 ), 2558 – 2566 .

Zhang, L. ; Deng, Q. Y. ; Zhou, L. ; Xia, Z. Y. ; Chen, S. L. ; Guo, X. Y. ; Peng, H. L. ; Zhang, C. Y. ; Gao, H. Y. ; Cheng, D. B. ; Fu, Z. Y . Recent advancements in the design and application of Thioctic acid-based self-assembled materials . Coord. Chem. Rev. , 2025 , 537 , 216679 .

Tan, P. ; Gu, W. X. ; Zou, Y. W. ; Song, X. ; Huang, Z. H. ; Liu, J. ; Lei, I. M . Harnessing dynamic covalent chemistry in sustainable biomass-based polymers: synthesis, dynamic functionalities and potential of dithiolane-containing supramolecular polymers . Prog. Polym. Sci. , 2025 , 160 , 101920 .

Zhang, H. T. ; Hou, L. K. ; Chu, G. W. ; Wang, J. X. ; Zhang, L. L. ; Chen, J. F . Cationic ring-opening polymerization of natural thioctic acid to chemically recyclable and self-healable poly(thioctic acid) supramolecular material . Chem. Eng. J. , 2024 , 482 , 148816 .

Meot-Ner Mautner, M . The ionic hydrogen bond . Chem. Rev. , 2005 , 105 ( 1 ), 213 – 284 .

Nelson, B. R. ; Kirkpatrick, B. E. ; Miksch, C. E. ; Davidson, M. D. ; Skillin, N. P. ; Hach, G. K. ; Khang, A. ; Hummel, S. N. ; Fairbanks, B. D. ; Burdick, J. A. ; Bowman, C. N. ; Anseth, K. S. . Photoinduced dithiolane crosslinking for multiresponsive dynamic hydrogels . Adv. Mater. , 2024 , 36 ( 43 ), 2211209 .

Shi, C. Y. ; Zhang, Q. ; Wang, B. S. ; Chen, M. ; Qu, D. H . Intrinsically photopolymerizable dynamic polymers derived from a natural small molecule . ACS Appl. Mater. Interfaces , 2021 , 13 ( 37 ), 44860 – 44867 .

Wang, Y. ; Liu, K. ; Wei, W. Y. ; Dai, H. L . A multifunctional hydrogel with photothermal antibacterial and antioxidant activity for smart monitoring and promotion of diabetic wound healing . Adv. Funct. Mater. , 2024 , 34 ( 38 ), 2402531 .

Liu, K. ; Kang, Y. ; Dong, X. Z. ; Li, Q. Y. ; Wang, Y. ; Wu, X. P. ; Yang, X. F. ; Chen, Z. B. ; Dai, H. L . A simple yet effective hydrogel dressing for advanced microenvironmental management of diabetic wounds with intrinsic regulation . Chem. Eng. J. , 2023 , 470 , 143987 .

Pang, Z. X. ; Li, Q. Y. ; Liu, K. ; Wu, X. P. ; Xu, H. X. ; Chen, Z. B. ; Dai, H. L . Efficacy of melanin-loaded lipoic acid-modified chitosan hydrogel in diabetic wound healing . Carbohydr. Polym. , 2024 , 340 , 122215 .

Pang, Z. X. ; Yao, Y. W. ; Xu, Z. A. ; Liu, K. ; Wu, X. P. ; Zhang, X. L. ; Dai, H. L . Natural polymer chitosan-based hydrogels can enhance mechanical properties and produce H 2 S gas by UV-light to treat scalded wound . Int. J. Biol. Macromol. , 2025 , 306 , 141289 .

Zhong, Y. X. ; Zhang, Y. F. ; Liu, Y. T. ; Zeng, K. ; Fan, L. ; Wang, Q. ; Zhang, J. L . Adhesive hydrogel based on Konjac Glucomannan (KGM) loaded with siACTC1-exosomes for enhanced post-surgical keloid treatment . Int. J. Biol. Macromol. , 2025 , 319 , 145360 .

Liu, H. ; Deng, Z. W. ; Li, T. H. ; Bu, J. Q. ; Wang, D. ; Wang, J. H. ; Liu, M. ; Li, J. C. ; Yang, Y. J. ; Zhong, S. A . Fabrication, GSH-responsive drug release, and anticancer properties of thioctic acid-based intelligent hydrogels . Colloids Surf. B Biointerfaces , 2022 , 217 , 112703 .

Wang, L. ; Fan, G. J. ; Zhu, L. J. ; Zhang, Y. Z. ; Wang, X. X. ; Qin, J. M. ; Lu, K. L. ; Hu, J. X. ; Ma, J. L . A lipoic acid supramolecular polymer-based hydrogel with self-regulating ROS, reduced blood sugar, and antibacterial ability for improved diabetic wound healing . J. Sci. Adv. Mater. Devices , 2024 , 9 ( 2 ), 100677 .

Liang, M. ; Wei, D. D. ; Ren, P. F. ; Xu, L. ; Tao, Y. H. ; Yang, L. X. ; Jiao, G. H. ; Zhang, T. Z. ; Serizawa, T . A visible light cross-linked underwater hydrogel adhesive with biodegradation and hemostatic ability . Adv. Healthc. Mater. , 2024 , 13 ( 7 ), 2302538 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Decoding Supramolecular Hydrogels: From Programmable Mechanics to Biological Effects

Progress of In situ Polymerization within Cellular Microenvironment in Biomedical Applications

A Review of Polyurethane Composite Materials in Biomedical Application

Protein Resistant Materials and Their Applications in Biomedical Field

Related Author

BIAN Li-ming

ZHANG Kun-yu

CHEN Ze-kun

LIU Jia-chang

LV Nian-nian

ZHU Jin-tao

JIANG Hao

MA Teng

Related Institution

School of Biomedical Sciences and Engineering, South China University of Technology

School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST)

School of Materials and Energy, Guangdong University of Technology

School of Chemical Engineering and Technology , Tianjin University

Technical Center for Safety of Industrial Products of Tianjin Entry-Exit Inspection and Quarantine Bureau of P. R. China

⁰

Progress on Poly(α-lipoic acid)-based Adhesive Hydrogels

DOI：10.14028/j.cnki.1003-3726.2025.25.240

摘要

Abstract

关键词

Keywords

references