Recent Progress in the Design of Tough Polyzwitterionic Hydrogels

LIU Bing-jie; XU Chen; TANG Yue-man; ZHENG Si-yu; YANG Jin-tao

doi:10.14028/j.cnki.1003-3726.2025.25.249

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Recent Progress in the Design of Tough Polyzwitterionic Hydrogels

更新时间：2026-01-16

- Recent Progress in the Design of Tough Polyzwitterionic Hydrogels
- Polymer Bulletin Vol. 39, Issue 1, Pages: 62-80(2026)
- 作者机构：
  
  浙江工业大学材料科学与工程学院　杭州 310014
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2025.25.249
  CLC：
- Received：30 August 2025，
  
  Accepted：09 October 2025，
  
  Published Online：04 December 2025，
  
  Published：20 January 2026
- 稿件说明：
移动端阅览
刘冰洁, 许晨, 唐悦蔓, 郑司雨, 杨晋涛. 高韧性两性离子聚合物水凝胶研究进展. 高分子通报, 2026, 39(1), 62–80.

Liu, B. J.; Xu, C.; Tang, Y. M.; Zheng, S. Y.; Yang, J. T. Recent progress in the design of tough polyzwitterionic hydrogels. Polym. Bull. (in Chinese), 2026, 39(1), 62–80.
刘冰洁, 许晨, 唐悦蔓, 郑司雨, 杨晋涛. 高韧性两性离子聚合物水凝胶研究进展. 高分子通报, 2026, 39(1), 62–80. DOI： 10.14028/j.cnki.1003-3726.2025.25.249.

Liu, B. J.; Xu, C.; Tang, Y. M.; Zheng, S. Y.; Yang, J. T. Recent progress in the design of tough polyzwitterionic hydrogels. Polym. Bull. (in Chinese), 2026, 39(1), 62–80. DOI： 10.14028/j.cnki.1003-3726.2025.25.249.

摘要

两性离子聚合物水凝胶凭借其在生物相容性、抗污性能和离子传输性能方面的独特优势受到全球研究人员的关注，现已在生物材料、离电器件、防污涂层等领域广泛应用。然而，两性离子基团极强的静电诱导水合效应会削弱聚合物链间的相互作用，致使相关凝胶的力学性能较差，极大地限制了其应用范围。本综述聚焦于两性离子聚合物水凝胶力学性能不足这一问题，首先讨论了两性离子单体的基本结构特征，分析了两性离子单元结构与体系内各类分子间作用之间的构效关系；随后以分子间作用力为纽带，分析了两性离子单元结构与两性离子聚合物水凝胶环境响应性之间的联系；然后，分别从两性离子聚合物杂化体系和纯两性离子聚合物体系两个方面系统梳理了近年来相关水凝胶的增韧策略，探讨了高韧性两性离子聚合物水凝胶单体结构和聚合物网络结构的设计思路；最后总结并展望了两性离子聚合物水凝胶未来发展时面临的挑战。

Abstract

Zwitterionic hydrogels have attracted tremendous attention owing to their unique advantages of biocompatibility

anti-fouling behavior

and ion transport capabilities

which have been widely applied in the fields of biomedical materials

ionotronics

and anti-fouling coatings. However

the strong electrostatically induced hydration effect of zwitterionic polymers leads to weak interactions between polymer chains

resulting in poor mechanical properties of zwitterionic gels

which significantly limits their applications. This review focuses on the issue of insufficient mechanical performance in zwitterionic hydrogels and demonstrates the corresponding toughening strategies. First

the fundamental structural features of zwitterions and the effect of zwitterionic structure on diverse molecular interactions were discussed

and the environmental responsiveness of zwitterionic gels was briefly analyzed. Subsequently

the toughening strategies of zwitterionic hydrogels reported in recent years were systematically reviewed

from both hybrid zwitterionic polymer systems and pure zwitterionic polymer systems. The effect of monomer and network structures on the mechanical properties of zwitterionic hydrogels was thoroughly discussed. Finally

the remaining challenges for the development of zwitterionic hydrogels were discussed.

关键词

Keywords

references

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