Advances in Strong and Tough Gelatin Hydrogels

REN Chun-ling; CHEN Ting; BAO Bing-kun; LIN Qiu-ning

doi:10.14028/j.cnki.1003-3726.2025.25.264

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Advances in Strong and Tough Gelatin Hydrogels

更新时间：2026-01-16

- Advances in Strong and Tough Gelatin Hydrogels
- Polymer Bulletin Vol. 39, Issue 1, Pages: 97-124(2026)
- 作者机构：
  
  上海交通大学生物医学工程学院　上海 200240
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2025.25.264
  CLC：
- Received：06 September 2025，
  
  Accepted：15 October 2025，
  
  Published Online：31 December 2025，
  
  Published：20 January 2026
- 稿件说明：
移动端阅览
任春玲, 陈婷, 鲍丙坤, 林秋宁. 高强韧明胶水凝胶研究进展. 高分子通报, 2026, 39(1), 97–124.

Ren, C. L.; Chen, T.; Bao, B. K.; Lin, Q. N. Advances in strong and tough gelatin hydrogels. Polym. Bull. (in Chinese), 2026, 39(1), 97–124.
任春玲, 陈婷, 鲍丙坤, 林秋宁. 高强韧明胶水凝胶研究进展. 高分子通报, 2026, 39(1), 97–124. DOI： 10.14028/j.cnki.1003-3726.2025.25.264.

Ren, C. L.; Chen, T.; Bao, B. K.; Lin, Q. N. Advances in strong and tough gelatin hydrogels. Polym. Bull. (in Chinese), 2026, 39(1), 97–124. DOI： 10.14028/j.cnki.1003-3726.2025.25.264.

摘要

明胶是胶原蛋白部分水解得到的天然多肽，具有优异的生物相容性、可降解性和细胞黏附性。基于此构筑的明胶水凝胶，不仅延续了明胶的生物学优势，还具备高含水量和结构可调性，在生物医学领域展现出广阔前景。但其固有的力学薄弱限制了其承载能力与长期应用潜力，尤其在复杂功能需求下更显不足。近年来，研究围绕性能优化与应用拓展，提出了包括交联调控、结构设计和复合策略在内的多种增强方法，并推动其在组织修复、药物递送和生物电子等方向的发展。本文系统总结了提升明胶水凝胶力学强度的设计理念与性能优化方法，梳理其最新应用进展，并讨论了未来发展中的核心挑战，为后续研究和临床转化提供参考。

Abstract

Gelatin is a natural polypeptide obtained by the partial hydrolysis of collagen

exhibiting excellent biocompatibility

degradability

and cell adhesion. In addition to having a high water content and structural tunability

gelatin hydrogels also inherit the biological benefits of gelatin

indicating a wide range of potential applications in the biomedical industry. Its load-bearing capacity and long-term applications are

however

limited by its intrinsic mechanical weakness

which is exacerbated by complex functional requirements. Researchers have put forth a range of reinforcement techniques

such as crosslinking regulation

structural design

and composite strategies

in recent years with an emphasis on performance optimization and application expansion. These techniques have further encouraged the use of gelatin hydrogels in industries like tissue repair

drug delivery

and bioelectronics. This review systematically summarizes the design concepts and performance optimization methods for enhancing the mechanical strength of gelatin hydrogels

sets out their most recent application progress

and discusses the key challenges and future directions in order to provide references for future research and clinical translation.

关键词

Keywords

references

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