Progress in Construction and Biomedical Application of Chiral Hydrogels

ZHAO Chang-li; FENG Chuan-liang

doi:10.14028/j.cnki.1003-3726.2025.25.266

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Progress in Construction and Biomedical Application of Chiral Hydrogels

更新时间：2026-01-16

- Progress in Construction and Biomedical Application of Chiral Hydrogels
- Polymer Bulletin Vol. 39, Issue 1, Pages: 1-19(2026)
- 作者机构：
  
  上海交通大学材料科学与工程学院　金属基复合材料全国重点实验室　上海 200240
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2025.25.266
  CLC：
- Received：08 September 2025，
  
  Accepted：11 October 2025，
  
  Published Online：20 November 2025，
  
  Published：20 January 2026
- 稿件说明：
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赵常利, 冯传良. 手性水凝胶构筑及其生物应用. 高分子通报, 2026, 39(1), 1–19.

Zhao C. L.; Feng, C. L. Progress in construction and biomedical application of chiral hydrogels. Polym. Bull. (in Chinese), 2026, 39(1), 1–19.
赵常利, 冯传良. 手性水凝胶构筑及其生物应用. 高分子通报, 2026, 39(1), 1–19. DOI： 10.14028/j.cnki.1003-3726.2025.25.266.

Zhao C. L.; Feng, C. L. Progress in construction and biomedical application of chiral hydrogels. Polym. Bull. (in Chinese), 2026, 39(1), 1–19. DOI： 10.14028/j.cnki.1003-3726.2025.25.266.

摘要

作为生命体系的基本属性，手性在生物分子识别、细胞行为调控及免疫应答等过程中发挥着关键作用。手性水凝胶结合了水凝胶优异的生物相容性、可调控的物理化学性质与手性结构的生物学特异性，已成为生物材料领域的研究热点。本文系统综述了手性水凝胶的构建策略，包括超分子自组装、高分子共价构筑及多组分共组装等方法，重点探讨了其在组织工程、免疫调控、癌症治疗等生物医学领域的应用进展，并对手性水凝胶在仿生材料、再生医学、免疫工程等方向的未来发展趋势进行了展望。

Abstract

Chirality

as a fundamental attribute of living systems

plays a pivotal role in biological processes such as molecular recognition

cellular behavior regulation

and immune responses. Chiral hydrogels

which integrate the exceptional biocompatibility and tunable physicochemical properties of hydrogels with the biological specificity conferred by chiral structures

have emerged as a prominent research focus in the field of biomaterials. This review systematically summarizes the fabrication strategies for chiral hydrogels

including supramolecular self-assembly

polymer-based covalent construction

and multi-component co-assembly approaches. It highlights recent advancements in their biomedical applications

particularly in tissue engineering

immunoregulation

and cancer therapeutics. Furthermore

future development trends of chiral hydrogels in biomimetic materials

regenerative medicine

and immune engineering are discussed and prospected.

关键词

Keywords

references

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