Research Progress and Tissue Engineering Applications of Stimuli-responsive Polymer Hydrogel Microspheres

DU Chen-xi; WANG Ran-ran; WEI Gang

doi:10.14028/j.cnki.1003-3726.2026.26.088

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Research Progress and Tissue Engineering Applications of Stimuli-responsive Polymer Hydrogel Microspheres

更新时间：2026-07-27

- Research Progress and Tissue Engineering Applications of Stimuli-responsive Polymer Hydrogel Microspheres
- Polymer Bulletin Vol. 39, Issue 8, Pages: 1292-1317(2026)
- 作者机构：
  
  青岛科技大学高分子科学与工程学院　青岛 266042
  青岛大学化学化工学院　青岛 266071
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2026.26.088
  CLC：
- Received：26 February 2026，
  
  Accepted：22 April 2026，
  
  Online First：13 July 2026，
  
  Published：20 August 2026
- 稿件说明：
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杜晨曦, 王冉冉, 魏刚. 刺激响应高分子水凝胶微球的制备及骨组织工程应用研究进展. 高分子通报, 2026, 39(8), 1292–1317.

Du, C. X.; Wang, R. R.; Wei, G. Research progress and tissue engineering applications of stimuli-responsive polymer hydrogel microspheres. Polym. Bull. (in Chinese), 2026, 39(8), 1292–1317.
杜晨曦, 王冉冉, 魏刚. 刺激响应高分子水凝胶微球的制备及骨组织工程应用研究进展. 高分子通报, 2026, 39(8), 1292–1317. DOI： 10.14028/j.cnki.1003-3726.2026.26.088.

Du, C. X.; Wang, R. R.; Wei, G. Research progress and tissue engineering applications of stimuli-responsive polymer hydrogel microspheres. Polym. Bull. (in Chinese), 2026, 39(8), 1292–1317. DOI： 10.14028/j.cnki.1003-3726.2026.26.088.

摘要

刺激响应高分子水凝胶微球作为一种兼具结构可设计性与动态调控能力的功能材料，在骨缺损修复、骨质疏松治疗、骨髓炎抗感染及骨关节炎调控等骨组织工程方面展现出重要应用潜力。本文围绕刺激响应高分子水凝胶微球的材料体系与结构设计，系统综述了其主要类型(温度、pH、光及多重刺激响应)及其响应机理，重点梳理了乳液法、喷雾法、微流控等微球构筑策略及其结构调控方法。在此基础上，归纳总结了其在骨缺损修复、抗感染调控及成骨促进等生物医学工程方面的应用进展，并从功能整合与作用机制角度进行分类分析。进一步讨论了当前存在的关键问题，包括响应精度不足、体内环境适配性有限以及结构稳定性与功能协同之间的矛盾。最后，对多刺激协同响应、结构精细化设计及临床转化方向的发展趋势进行了展望。

Abstract

Stimuli-responsive polymer hydrogel microspheres

as functional materials with tunable structures and dynamic regulatory capabilities

have demonstrated significant potential in bone tissue engineering

including applications in bone defect repair

osteoporosis treatment

anti-infection therapy for osteomyelitis

and osteoarthritis regulation. This review focuses on the material systems and structural design of stimuli-responsive polymer hydrogel microspheres. The main categories

including temperature-

pH-

light-

and multi-responsive systems

and their underlying mechanisms are systematically summarized. Particular emphasis is placed on microsphere fabrication strategies

such as emulsion

spray

and microfluidic methods

and their structural regulation approaches. On this basis

recent advances in their biomedical engineering applications

including bone defect repair

anti-infection regulation

and osteogenesis promotion

are comprehensively reviewed and classified from the perspectives of functional integration and mechanisms of action. Furthermore

the current challenges are discussed

including limited response precision

insufficient adaptability to complex

in vivo

environments

and trade-offs between structural stability and functional performance. Finally

future perspectives are proposed

highlighting multi-stimuli synergistic systems

refined structural designs

and clinical translation.

关键词

Keywords

references

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