最新刊期
卷 26 ， 期 1 ， 2013
- 摘要：The macroporous polymeric adsorbents have been widely applied in separation and purification of natural products due to its structure is easy to control, adsorption selectivity is high, and its use is renewable. In this article, the several research progresses for synthesis and application of the polymeric adsorbent was reviewed, mainly divided into two aspects: (1) Structure of the polymeric adsorbent matrix was designed base on the synergistic effect of multiple weak interactions, such as hydrogen bonding interaction, electrostatic interaction, dipolar interaction, and so on. Meanwhile, the hydrophobic skeleton of the adsorbent was also controlled purposely according to the structure characteristic of the adsorbates. This adsorbent can be used to prepare the high purity extract of the special active component in natural product, even to separate the monomer components in one kind of effective principle. (2) Controlling of the pore structure of the adsorbent mainly focus on the pore formed method. In order to get the narrow distribution of the pore diameter of the adsorbent, the traditional non-solvating pore formed method was changed to post crosslink of methylene between the initial structures of the polystyrene adsorbent based on the Friedel-Craft Alkylation reaction. As the result, this kind of adsorbent should exhibit the double function of adsorption and sieving effect.关键词：Polymeric adsorbent;Synergistic effect;Adsorption selectivity;Natural product
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发布时间：2022-09-18 - 摘要：The molecular imprinting technique can be defined as the formation of specific nano-sized cavities by means of the facile template-directed synthesis. The resulting molecularly imprinted polymers (MIPs) are characterized by their high affinity and specificity, easy preparation, and good thermal and chemical stability, which makes them highly promising in many potential applications, including their use for separation and isolation purposes, as antibody mimics (biomimetic assays and sensors), as enzyme mimics, in organic synthesis, in drug delivery, and in biomedicine. The ultimate goal of the molecular imprinting research is to prepare MIPs with an affinity and a selectivity approaching those of the biological receptors such as antibodies and eventually replace them in real applications. Among various problems associated with the presently developed MIPs, the facile and efficient preparation of MIPs applicable in aqueous solutions remains a challenging task. This paper presents a review of the recent progress in the development of such advanced water-compatible MIPs, with an emphasis on our strategies to solve this problem.关键词：Molecularly imprinted polymers;Synthetic receptor;Molecular recognition;Aqueous system
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发布时间：2022-09-18 - 摘要：Hydrogels have found wide applications in biomedical field because of their good biocompatibility and stimuli-responsivity, however, some drawbacks, such as weak mechanical strength, slow response rate and lack of biodegradability, still need to be resolved. In recent years, we designed a series of biomaterials, mainly based on the thermosensitive poly(N-isopropylacrylamide) (PNIPAM) microgels, to be used as drug carriers, biosensors and cell scaffolds. The major problem we aimed to resolve is the slow response of the hydrogel biomaterials. We have designed and prepared PNIPAM microgels with good glucose-sensitivity, which were used for self-regulated insulin release. We proposed a new polymerized crystalline colloidal array optical sensing method and developed several optical biosensors which can respond quickly. We also achieved the in situ gelation of concentrated PNIPAM microgel dispersions, which were further developed as a new injectable 3D cell scaffold. Also based on the reversibility of this system, we proposed a new method for the fabrication of multicellular spheroids, which have important applications in drug screening, cancer study and tissue engineering.关键词：Hydrogels;Microgels;Drug delivery;Biosensing;Cell scaffolds
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发布时间：2022-09-18 - 摘要：Layer-by-layer (LbL) assembly is a method for the fabrication of polymer films exploiting the interactions between a pair of polymers, such as electrostatic interaction, hydrogen bonding, and covalent bonding. Since it is simple, requires no special instruments, and has a fine control of the film composition and thickness, it has found applications in the fabrication of devices, surface modification and various biomedical fields. Our efforts in this area include both fundenmental issues and biomedical applications. We first extended the LbL methods based on hydrogen bonding and covalent bonding from 2D systems to 3D systems and fabricated hollow capsules based on hydrogen bonds and covalent bonds. We proposed a general method for the fabrication of single component LbL films and capsules. Using poly(vinylpyrrolidone)/polyacrylic acid film as example, we studied the hydrogen-bonded LbL films extensively. We also first fabricated LbL films using the reversible covalent bond (i.e., phenyl boronate ester bond) as the driving force. Based on these experiments, we recently proposed the conception of dynamic layer-by-layer assembled films. A new drug delivery method has been proposed which exploits the gradual disintegration of dynamic LbL films. We also proposed a new fast-responding optical sensing method based on stimuli-responsive hydrogel films fabricated via LbL assembly.关键词：Layer-by-layer assembly;Drug delivery;Biosensing
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发布时间：2022-09-18 - 摘要：As the center of the natural photochemical reaction, porphyrin and its derivates have attracts more attention from the scientists. Aggregates of porphyrin with different optical properties can be obtained from nanometer to micron with various morphologies. 5,10,15,20-tetrakis-(4-sulfonatophenyl)-porphyrin (TPPS) can form chiral aggregates under some small perturbations. Cationic block copolymer can form complex aggregates with TPPS or its aggregates through electrostatic interactions. These aggregates have stable and tunable chirality and disperse as colloidal solution with a controllable size. This article reviewed the origin of the chiral aggregate and the latest developments in this field. We mainly discuss the preparation and character of the cationic block copolymer/TPPS complex aggregate based on our published work. Finally, some possible approaches in this field are proposed and the prospective on the future development is tentatively discussed.关键词：Block copolymer;Chiral complex aggregate;Supramolecular chirality;Circular dichroism spectrum
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发布时间：2022-09-18 - 摘要：Gold nanoparticles (AuNPs) present many fascinating properties such as size-related electronic, magnetic and optical properties, and polymers have the properties of processability and stimulative responsibility. Nanocomposites of polymers and AuNPs have both the properties of AuNPs and polymers, so researches on the nanocomposites have aroused much interest over the past decade. In this paper we introduce briefly our researches on the self-assembly of AuNPs at oil-water interface and fabrication of polymer-AuNPs ordered structures. Following different research topics are presented: (1) synthesis and self-assembly of polystyrene with pendant AuNPs;(2) interface-directed self-assembly of AuNPs and preparation of colloidal particles with AuNPs on the surface;(3) preparation of micro-hydrogels with AuNPs as cross-linkers.关键词：Gold nanoparticles;Oil-water interface;Self-assembly;Amphiphilicity
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发布时间：2022-09-18 - 摘要：The microstructure and dynamics determine the final physical and chemical properties of macromolecules, and are of typical multiple length and time scale. The characterization of multi-scale structure and dynamics of polymers and their evolution at different length and time scale, and hence elucidation of their structure-property relationship is still a challenge in polymer science. Nowadays, solid-state NMR is a powerful tool in investigating the hieratical structure and complex motion in solid polymers at length scale from atom to 100 nm and time scale from 10-7 to 10s, and in elucidating the structure-property relationship. In this article, we will review the comprehensive multi-scale solid-state NMR techniques that we systematically constructed recently, and the application of these techniques in the study of polymer microstructure, segmental miscibility and interchain interaction, interphase and microdomain size, as well as the complex dynamics.关键词：Macromolecules;Multiscale;Structure;Dynamics;Solid-state NMR
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发布时间：2022-09-18 - 摘要：In this account, we repoted our efforts in the development of polyoxometalate-polymer hybrids (PPHs) using new polymerization methods. It is worthy to point out that the polyoxometalate clusters are covalently linked with polymers in the PPHs. Our target is to prepare a high value-added PPH materials with functionalities of polyoxometalates and processability of polymers. In our work we have desgined and sythesized two kinds of PPHs using atom transfer radical polymerization (ATRP) and clicking reaction, respectively. Meanwhile we studied the self-assembled structures and morphologies of the PPHs that strongly affected by the special architecture of polyoxometalates. This work reflects an interdiscipline of polyoxometalate chemistry, polymer chemistry and supramolecular self-assembly. Our findings will provide a new pastway in creating novel functional materials.关键词：Hybrid materials;Polymers;Polyoxometallets
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发布时间：2022-09-18 - 摘要：Thermodynamic analysis indicates that the energy of an association between a molecule and a larger entity driven by multiple noncovalent interactions is greater than the sum of the energies of these interactions when they act alone. In other words, there is synergistic effect between these multiple noncovalent interactions. The utilization of multiple noncovalent interactions (e.g., hydrophobic effect, ionic interaction and hydrogen bonding) and their synergistic effect in the design of adsorption and controlled drug delivery systems is discussed. A noncovalent interaction (such as a hydrogen bond in aqueous medium) that does not contribute to an association when it acts alone may contribute to the association when it acts cooperatively with other noncovalent interactions. Not only can higher solute adsorption and drug load capacities be obtained, but also the adsorption selectivity and drug release behavior can be controlled by correct utilization of multiple noncovalent interactions and their synergistic effect.关键词：Multiple noncovalent interactions;Synergistic effect;Adsorption;Controlled drug delivery
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发布时间：2022-09-18 - 摘要：As a kind of materials that can highly recognize specific substrate selectively, MIP has recently received more and more attention to develop accurate detection methods and elimination means in the field of environmental pollution. In this paper, firstly, the concept of MIP is introduced;secondly, MIP used recently in environmental governance is reviewed, mainly include heavy metal ions, aromatic compounds and pesticides pollution, discuss about MIP for rapid and sensitive detection as well as convenient and effective elimination of these three types of environmental pollutions;in addition, MIP used in the real sample is also discussed;finally, its future research aspects in environmental pollution control is also put forward.关键词：Molecular imprinting;Environmental governance;Heavy metal ions;Aromatic compounds;Pesticides
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发布时间：2022-09-18 - 摘要：In the areas such as biotechnologies and life science, separation, analysis and detection of a target protein is achieved commonly relying on antibody-based specific interactions. Molecularly imprinted polymers against proteins are regarded as the most potential substitutes for the costly antibodies. However, successful imprinting of a protein is faced with some problems, one of which is the limited macromolecule diffusion throughout the cross-linked protein-imprinted polymer networks. Nanostructured protein-imprinted polymers can overcome this problem to a great extent, with relatively high ratio of surface area to volume and easily accessed imprinting sites. Herein, we review various approaches reported previously for constructing the nanosized protein-imprinted materials, particularly addressing the advantages and shortcomings associated with each method. The potential applications of these protein-imprinted materials are also described.关键词：Molecular imprinting;Protein imprinting;Protein recognition;Nanostructures
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发布时间：2022-09-18 - 摘要：Liver disease is one of the most serious deseases which pose significant health challenge worldwide. Advances in treatment, detection, surgical techniques have resulted in considerable improvements in therapy of liver disease. It has aroused extensive attention of researchers that targeted drug delivery system can delivery the drug selectively to the target tissue, thereby improving the bioavailability of the drug and reduce its side effects. In recent years, increasing researchers have attempted to apply targeted drug delivery system (TDDS) to the imaging detection of the liver disease and drug/gene therapy, and achieved significant results. This review addresses the latest development of the liver TDDS in recent years, especially the ligand/receptor-mediated liver TDDS in drug/gene delivery or imaging detection;summarize the liver targeting ability of different TDDS, and then discusses the challenges and future perspectives for the development of liver TDDS.关键词：Liver targeted;Drug delivery;Passive targeted;Active target;Ligand/Receptor-Mediated
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发布时间：2022-09-18 - 摘要：Poly(amino acid)s have been extensively studied in biomedical applications, due to their excellent biocompatibility, biodegradability and various side groups for further functionalization. Poly (aspartic acid) can be synthesized by thermal polycondensation of L-aspartic acid, which is easily controlled and not costly. Its metabolites are non-toxic and would not produce toxic side effects to the surrounding tissue, liver, kidney, and red blood cells. It would be a good candidate for preparing polypeptide derivatives and was widely studied as the drug carriers, tissue engineering materials, etc. In this paper, research on poly(aspartic acid)s in the field of biomedical materials in recent years was reviewed, and mainly focused on the design and synthesis of poly (alpha, beta-L-aspartic acid) derivatives and their biomedical properties.关键词：Poly (aspartic acid)s;Drug delivery;Biodegradability;Anti-protein adsorption
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发布时间：2022-09-18 - 摘要：Glycopolymers have attracted increasing attention in the fields of polymer science and material science because of good biocompatibility and biological recognition of sugar moieties. The advances of controlled radical polymerization and "click" chemistry provide versatile approaches to generate various functional glycopolymers with controlled structures. In this paper, new progresses in the synthesis of functional glycopolymers via RAFT polymerization and the combination of controlled radical polymerization and "click" chemistry were introduced. Our researches on stimuli-responsive block glycopolymers and glycopolymer-peptide bioconjugates were also summarized.关键词：Glycopolymer;Controlled radical polymerization;Bioconjugate;"Click" chemistry
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发布时间：2022-09-18 - 摘要：The reversible addition-fragmentation-transfer (RAFT) dispersion polymerization is a typical controlled/ling radical polymerization under heterogeneous condition, which has the advantage to prepare micro-sized or nano-sized polymer particles with well-defined polymer molecular weight and low molecular weight distribution. In this manuscript, the dispersion polymerizations mediated with a small RAFT agent and a macromolecular RAFT (Macro-RAFT) agent are reviewed, and the polymerization kinetics, the polymer particle nucleation, and the polymer particle growth during the RAFT dispersion polymerizations are introduced. The difference between the dispersion polymerizations mediated with a small RAFT agent and a Macro-RAFT agent is revealed. The small RAFT agent mediated dispersion polymerization is generally performed under the heterogeneous condition similarly with the general radical dispersion polymerization, and micro-sized polymer particles are prepared at most cases. Whereas, an initial slow homogeneous polymerization before the block copolymer micellization and a subsequent fast heterogeneous one after the block copolymer micellization are involved in the Macro-RAFT agent mediated dispersion polymerization, and nano-sized block copolymer colloids are usually prepared.关键词：Reversible addition-fragmentation-transfer (RAFT) polymerization;Dispersion polymerization;Block copolymers
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发布时间：2022-09-18
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