最新刊期
卷 29 ， 期 5 ， 2016
- 摘要：Nano-drug delivery systems are extensively investigated due to their specific properties. The nano-drug delivery systems were introduced briefly and this review focused on the fabrication of nano-drug delivery systems based on π-π stacking interaction between anticancer drugs and carriers, the recent progresses in drug delivery systems based on π-π stacking interaction including polymeric micelles, carbon nanomaterials of carbon nanotube and graphene and injectable low molecular weight gels were reviewed.关键词：Drug delivery systems;π-π Stacking interaction;Chemotherapy
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发布时间：2022-09-12 - 摘要：Polycaprolactone ( PCL) is a hydrophobic,semi-crystalline and biodegradable aliphatic polymer. A good biocompatibility and mechanical properties of PCL has stimulated extensive attention in the drug delivery and tissue engineering. However, the major drawback of the PCL is highly crystalline, low hydrophilic and slow biodegradation which limited its widely application in the biomedical field. The introduction of functional groups into commonly used PCL make it possible to further chemical modification as well as tune its physicochemical properties such as hydrophilicity and degradation rate,which makes PCL more suitable for biomedical applications. This review will focus on the prepared method of PCL with pendent functional groups, and briefly discussed its application in the biomedical areas.关键词：PCL;Functional;Drug delivery;Tissue engineering
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发布时间：2022-09-12 - 摘要：Polyphosphazenes are hybrid inorganic-organic polymers composed of a backbone containing alternative phosphorus and nitrogen atoms with two (usually organic) side groups linked to each phosphorus atom. Various properties can be obtained due to the high flexibility in molecular design of polyphosphazene chemistry. Biocompatibility, biodegrability and functionalization are among the key factors in determining the applications of biodegradable polyphosphazenes in biomedical fields. In this paper, functional polyphosphazene-based biomaterials, including cationic polyphosphazene, photoluminiscent polyphosphazene, conducting polyphosphazene, and polyphosphazene-polyester copolymer etc.,were reviewed to introduce their recent developments. These functional polyphosphazenes can find wide applications in biomedical areas as tissue engineering scaffolds, drug and gene delivery carriers.关键词：Polyphosphazene;Biodegradable;Functionalization
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发布时间：2022-09-12 - 摘要：Biodegradable polymers are widely applied in medicine such as orthopedic internal fixation,controlled/ sustained drug release, tissue engineering scaffolds, and cardiovascular stents. Appropriate biodegradation is critical for those medical applications. A classical detection of biodegradation requires a large number of material samples and animals. Alternatively, some imaging techniques have been explored for non-invasive assessment of the degradation profile of an individual sample in situ. This review summarizes the recent advances in the field of in situ and non-invasive characterization of biodegradable polymeric materials, with emphasis of fluorescence imaging, photoacoustic/ultrasound imaging, and electrochemical method.关键词：Biomedical polymer;Biodegradable;Fluorescence imaging;Photoacoustic and ultrasound imaging;Electrochemical method
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发布时间：2022-09-12 - 摘要：The current researches of biomaterial-based scaffolds applied in the repair of the experimental spinal cord injury were reviewed, which biomaterials presented included use and development of various injectable hydrogel and preformed natural polymers, extra cellular matrix and synthetic polymers appeared in the recent decade. Related material constitutes, fabrication techniques, application modules used in vitro and vivo as well as potential development were introduced and discussed.关键词：Spinal cord injury;Tissue engineering;Biomaterial;Scaffold;Regeneration
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发布时间：2022-09-12 - 摘要：Graphene because of its unique structure and excellent physical and chemical properties has became an advanced research hotspot in a broad range of areas. Graphene and its derivatives have broad potential applications in biomedical engineering and biotechnology. This article will summarize the latest research progress and application of grapheme in the field of biomedical research, including biosensing, disease diagnosis, drug and gene delivery, antibacterial and antiviral, bioimaging,photothermal and photodynamic therapy, tissue engineering. Finally, we summarize the biological safety and biodegradability of graphene, and discuss the outlook of graphene in the application of biomedical field.关键词：Graphene;Biomedical;Biocompatibility
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发布时间：2022-09-12 - 摘要：The carbohydrates not only constitute the major components of life, but also are involved in a wide range of physiological and pathological processes, such as molecular recognition and cellular interactions. The biological functions of carbohydrate are achieved by specific interactions with proteins, playing an important role in signal transduction, cell adhesion, proliferation, differentiation, and inflammation and immunization. Besides the introduction of classification and mechanism for carbohydrate-protein interactions, this article briefly summarizes three main applications in biomedical field, including modification of nanoparticles with carbohydrate for drug delivery and gene transfection, formation of unique two- and three-dimensional supermolecular assemblies,and surface glycosylation to modulate protein adhesion and cell behaviors. More applications as intelligent biomaterials are expected to be explored in the future based on the carbohydrate- protein interactions.关键词：Biomaterials;Carbohydrate;Protein;Specific interactions
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发布时间：2022-09-12 - 摘要：This paper reviewed the application of plant lectins as biomedical materials. The discovery history of plant lectins and its classification were firstly introduced. Then we clearly summarized their applications in targeting drug carrier, stimuli-responsive drug carrier, targeting and stimuli-responsive drug carrier, biological sensors and polymer materials. The advantages as well as the challenges for using plant lectins as bio-function materials were also addressed.关键词：Plant lectins;Carbohydrate-binding protein;Biomedical materials
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发布时间：2022-09-12 - 摘要：Hydrogels have been extensively used in biomedical applications such as tissue engineering, drug delivery and biosensing. The use of microfabrication technology to engineer the size and shape of biologically relevant microscaled hydrogels has generated new opportunities in addressing challenges in tissue engineering such as vascularization, tissue architecture and cell seeding. Here, the actualities of the research in microengineered hydrogels for tissue engineering applications are reviewed. We will initially provide an overview of the various approaches used to fabricate hydrogels with microscale features, and then discuss their applications in addressing the challenges of vascularization and tissue complexity within tissue engineered constructs.关键词：Tissue engineering;Microfabrication;Micro-scaled hydrogel;Assembly;Tissue construction
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发布时间：2022-09-12
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