Polylactic-acid(PLA) nanoparticles has advantages of controlled release of drug molecules
totarget sites
reduce side effect and improve therapeutic effect.It has a widely research and application perspective in drug delivery system. But the application of PLA nanoparticles is restricted because of hydrophobicity and single molecular chain.The researches of modified PLA nanoparticles for the drug delivery system are summarized.It focuses on the recent developments in resolving the existent problem of clinical application
ranging from hydrophilic modified to targeted modified.