Biomaterials

especially blood-contact materials

to meet antithrombogenic requirement is the first premise for clinical application. Surface modification for blood compatibility improvement is simple and feasible. Surface modification includes two aspects of surface design and method design. In the present paper

several surface design strategies for antithrombogenic polymeric materials including micro-phase separated structure design

surface phase seperation design

negative charge surface design

hydrophilic/hydrophobic surface design

bioactive surface design

endothelialization surface design

and zwitterionic surface design were reviewed. Among them

zwitterionic antithrombogenic surface design was highlighted.