The supercritical anti-solvent (SAS) technology

as a novel technology for the preparation of micro- and nano-particles

has been widely applied in variety of different fields including: superconductors

color matter

polymers

explosives and pharmaceutical compounds. The review discusses the process and how to simultaneously adjust and control the particle size and its distribution

morphology

crystallinity and so on with this facile approach. And the effects of polymer structure on preparation of fine particles is illustrated. In the present review

the application of SAS in the preparation of composite particles with the polymers as the continuous solid phase or coating solid phase were also focused on. The particle formation mechanism in the SAS process was summarized. The problems in these areas are presented

and the future development are proposed as well.