Natural extracellular matrixs are net-like being composed of fibrin and fibers in nanoscale (50 〜500nm). From the biomimetic viewpoint
electrospinning technique would be a proper method to produce fibrous network mimicking the natural extracellular matrixes. Diameters of electrospun fibers range from tens of nanometers to micrometers
porous structures resulted from the loosely deposited fibers are of high porosity and high surface area
which are good choice for tissue engineering by providing proper environment for cells proliferation and differentiation. In this paper
an introduction to the preparation and biomedical application of several functional nanofibers is summarized basing on recent literature reports and the research works in our lab
focusing on developing novel regeneration materials for dental and hard tissue restoration.