Meng-hong JIA, Jie REN, Tian-bin REN. Preparation and Characterization of the Magnetic and Thermo-responsive Drug Carrier[J]. Polymer Bulletin, 2013,26(7):50-55.
Meng-hong JIA, Jie REN, Tian-bin REN. Preparation and Characterization of the Magnetic and Thermo-responsive Drug Carrier[J]. Polymer Bulletin, 2013,26(7):50-55.DOI:
A certain molecular structure of the PNIPAAm-PLA block copolymer is synthesized. Dialysis is applied to prepare the PNIPAAm-PLA magnetic composite micelles and vesicles. Different preparation conditions form micelles and vesicles respectively
and the morphology of the two carrier s is contrasted. Two structures of the carrier are suitable for the loading of hydrophobic drug and hydrophilic drugs respectively.The LCST of composite micelles is characterized
its LCST is around 38℃
which is little higher than normal body temperature. Different feed ratios of Fe
4
O
3
magnetic particles leads to different magnetic properties of micelles
but the ratio doesn’t play an important role in magnetic property.